Cardiovascular magnetic resonance imaging-derived intraventricular pressure gradients in ST-segment elevation myocardial infarction

Recently, novel post-processing tools have become available that measure intraventricular pressure gradients (IVPGs) on routinely obtained long-axis cine cardiac magnetic resonance (CMR) images. IVPGs provide a comprehensive overview of both systolic and diastolic left ventricular (LV) functions. Wh...

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Autores: Konijnenberg, Lara S F.|||0000-0002-2634-2864, Beijnink, Casper W H., van Lieshout, Maarten, Vos, Jacqueline L., Rodwell, Laura|||0000-0003-2706-9326, Bodi, Vicente|||0000-0001-6425-5828, Ortiz-Pérez, José T., van Royen, Niels|||0000-0001-6136-8640, Rodríguez Palomares, José Fernando|||0000-0002-8822-5532, Nijveldt, Robin
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:307587
Acceso en línea:https://ddd.uab.cat/record/307587
https://dx.doi.org/urn:doi:10.1093/ehjimp/qyae009
Access Level:acceso abierto
Palabra clave:ST-elevation myocardial infarction
Cardiac magnetic resonance imaging
Microvascular injury
Feature tracking
Intraventricular pressure gradients
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spelling Cardiovascular magnetic resonance imaging-derived intraventricular pressure gradients in ST-segment elevation myocardial infarctiona long-term follow-up studyKonijnenberg, Lara S F.|||0000-0002-2634-2864Beijnink, Casper W H.van Lieshout, MaartenVos, Jacqueline L.Rodwell, Laura|||0000-0003-2706-9326Bodi, Vicente|||0000-0001-6425-5828Ortiz-Pérez, José T.van Royen, Niels|||0000-0001-6136-8640Rodríguez Palomares, José Fernando|||0000-0002-8822-5532Nijveldt, RobinST-elevation myocardial infarctionCardiac magnetic resonance imagingMicrovascular injuryFeature trackingIntraventricular pressure gradientsRecently, novel post-processing tools have become available that measure intraventricular pressure gradients (IVPGs) on routinely obtained long-axis cine cardiac magnetic resonance (CMR) images. IVPGs provide a comprehensive overview of both systolic and diastolic left ventricular (LV) functions. Whether IVPGs are associated with clinical outcome after ST-elevation myocardial infarction (STEMI) is currently unknown. Here, we investigated the association between CMR-derived LV-IVPGs and major adverse cardiovascular events (MACE) in a large reperfused STEMI cohort with long-term outcome. In this prospectively enrolled multi-centre cohort study, 307 patients underwent CMR within 14 days after the first STEMI. LV-IVPGs (from apex-to-base) were estimated on the long-axis cine images. During a median follow-up of 9.7 (5.9-12.5) years, MACE (i.e. composite of cardiovascular death and de novo heart failure hospitalisation) occurred in 49 patients (16.0%). These patients had larger infarcts, more often microvascular injury, and impaired LV-IVPGs. In univariable Cox regression, overall LV-IVPG was significantly associated with MACE and remained significantly associated after adjustment for common clinical risk factors (hazard ratio (HR) 0.873, 95% confidence interval (CI) 0.794-0.961, P = 0.005) and myocardial injury parameters (HR 0.906, 95% CI 0.825-0.995, P = 0.038). However, adjusted for LV ejection fraction and LV global longitudinal strain (GLS), overall LV-IVPG does not provide additional prognostic information (HR 0.959, 95% CI 0.866-1.063, P = 0.426). Early after STEMI, CMR-derived LV-IVPGs are univariably associated with MACE and this association remains significant after adjustment for common clinical risk factors and measures of infarct severity. However, LV-IVPGs do not add prognostic value to LV ejection fraction and LV GLS. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/307587https://dx.doi.org/urn:doi:10.1093/ehjimp/qyae009reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3075872026-06-06T12:50:31Z
dc.title.none.fl_str_mv Cardiovascular magnetic resonance imaging-derived intraventricular pressure gradients in ST-segment elevation myocardial infarction
a long-term follow-up study
title Cardiovascular magnetic resonance imaging-derived intraventricular pressure gradients in ST-segment elevation myocardial infarction
spellingShingle Cardiovascular magnetic resonance imaging-derived intraventricular pressure gradients in ST-segment elevation myocardial infarction
Konijnenberg, Lara S F.|||0000-0002-2634-2864
ST-elevation myocardial infarction
Cardiac magnetic resonance imaging
Microvascular injury
Feature tracking
Intraventricular pressure gradients
title_short Cardiovascular magnetic resonance imaging-derived intraventricular pressure gradients in ST-segment elevation myocardial infarction
title_full Cardiovascular magnetic resonance imaging-derived intraventricular pressure gradients in ST-segment elevation myocardial infarction
title_fullStr Cardiovascular magnetic resonance imaging-derived intraventricular pressure gradients in ST-segment elevation myocardial infarction
title_full_unstemmed Cardiovascular magnetic resonance imaging-derived intraventricular pressure gradients in ST-segment elevation myocardial infarction
title_sort Cardiovascular magnetic resonance imaging-derived intraventricular pressure gradients in ST-segment elevation myocardial infarction
dc.creator.none.fl_str_mv Konijnenberg, Lara S F.|||0000-0002-2634-2864
Beijnink, Casper W H.
van Lieshout, Maarten
Vos, Jacqueline L.
Rodwell, Laura|||0000-0003-2706-9326
Bodi, Vicente|||0000-0001-6425-5828
Ortiz-Pérez, José T.
van Royen, Niels|||0000-0001-6136-8640
Rodríguez Palomares, José Fernando|||0000-0002-8822-5532
Nijveldt, Robin
author Konijnenberg, Lara S F.|||0000-0002-2634-2864
author_facet Konijnenberg, Lara S F.|||0000-0002-2634-2864
Beijnink, Casper W H.
van Lieshout, Maarten
Vos, Jacqueline L.
Rodwell, Laura|||0000-0003-2706-9326
Bodi, Vicente|||0000-0001-6425-5828
Ortiz-Pérez, José T.
van Royen, Niels|||0000-0001-6136-8640
Rodríguez Palomares, José Fernando|||0000-0002-8822-5532
Nijveldt, Robin
author_role author
author2 Beijnink, Casper W H.
van Lieshout, Maarten
Vos, Jacqueline L.
Rodwell, Laura|||0000-0003-2706-9326
Bodi, Vicente|||0000-0001-6425-5828
Ortiz-Pérez, José T.
van Royen, Niels|||0000-0001-6136-8640
Rodríguez Palomares, José Fernando|||0000-0002-8822-5532
Nijveldt, Robin
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ST-elevation myocardial infarction
Cardiac magnetic resonance imaging
Microvascular injury
Feature tracking
Intraventricular pressure gradients
topic ST-elevation myocardial infarction
Cardiac magnetic resonance imaging
Microvascular injury
Feature tracking
Intraventricular pressure gradients
description Recently, novel post-processing tools have become available that measure intraventricular pressure gradients (IVPGs) on routinely obtained long-axis cine cardiac magnetic resonance (CMR) images. IVPGs provide a comprehensive overview of both systolic and diastolic left ventricular (LV) functions. Whether IVPGs are associated with clinical outcome after ST-elevation myocardial infarction (STEMI) is currently unknown. Here, we investigated the association between CMR-derived LV-IVPGs and major adverse cardiovascular events (MACE) in a large reperfused STEMI cohort with long-term outcome. In this prospectively enrolled multi-centre cohort study, 307 patients underwent CMR within 14 days after the first STEMI. LV-IVPGs (from apex-to-base) were estimated on the long-axis cine images. During a median follow-up of 9.7 (5.9-12.5) years, MACE (i.e. composite of cardiovascular death and de novo heart failure hospitalisation) occurred in 49 patients (16.0%). These patients had larger infarcts, more often microvascular injury, and impaired LV-IVPGs. In univariable Cox regression, overall LV-IVPG was significantly associated with MACE and remained significantly associated after adjustment for common clinical risk factors (hazard ratio (HR) 0.873, 95% confidence interval (CI) 0.794-0.961, P = 0.005) and myocardial injury parameters (HR 0.906, 95% CI 0.825-0.995, P = 0.038). However, adjusted for LV ejection fraction and LV global longitudinal strain (GLS), overall LV-IVPG does not provide additional prognostic information (HR 0.959, 95% CI 0.866-1.063, P = 0.426). Early after STEMI, CMR-derived LV-IVPGs are univariably associated with MACE and this association remains significant after adjustment for common clinical risk factors and measures of infarct severity. However, LV-IVPGs do not add prognostic value to LV ejection fraction and LV GLS.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/307587
https://dx.doi.org/urn:doi:10.1093/ehjimp/qyae009
url https://ddd.uab.cat/record/307587
https://dx.doi.org/urn:doi:10.1093/ehjimp/qyae009
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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