Incidence and clinical manifestations of giant cell arteritis in Spain: results of the ARTESER register

Objective This study aimed to estimate the incidence of giant cell arteritis (GCA) in Spain and to analyse its clinical manifestations, and distribution by age group, sex, geographical area and season.Methods We included all patients diagnosed with GCA between 1 June 2013 and 29 March 2019 at 26 hos...

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Autores: Fernández-Lozano, D, Hernández-Rodríguez, I, Narvaez, J, Domínguez-Alvaro, M, De Miguel, E, Silva-Díaz, M, Belzunegui, JM, Morales, CM, Sánchez, J, Galíndez-Agirregoikoa, E, Aldaroso, V, Abasolo, L, Loricera, J, Garrido-Puñal, N, Alvarado, PM, Larena, C, Navarro, VA, Calvet, J, Casafont-Solé, I, Ortiz-Sanjuán, F, Monte, TCS, Castañeda, S, Blanco, R
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p17722
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17722
http://ddd.uab.cat/record/305611
Access Level:acceso abierto
Palabra clave:epidemiology
incidence
giant cell arteritis
vasculitis
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spelling Incidence and clinical manifestations of giant cell arteritis in Spain: results of the ARTESER registerFernández-Lozano, DHernández-Rodríguez, INarvaez, JDomínguez-Alvaro, MDe Miguel, ESilva-Díaz, MBelzunegui, JMMorales, CMSánchez, JGalíndez-Agirregoikoa, EAldaroso, VAbasolo, LLoricera, JGarrido-Puñal, NAlvarado, PMLarena, CNavarro, VACalvet, JCasafont-Solé, IOrtiz-Sanjuán, FMonte, TCSCastañeda, SBlanco, Repidemiologyincidencegiant cell arteritisvasculitisObjective This study aimed to estimate the incidence of giant cell arteritis (GCA) in Spain and to analyse its clinical manifestations, and distribution by age group, sex, geographical area and season.Methods We included all patients diagnosed with GCA between 1 June 2013 and 29 March 2019 at 26 hospitals of the National Health System. They had to be aged >= 50 years and have at least one positive results in an objective diagnostic test (biopsy or imaging techniques), meet 3/5 of the 1990 American College of Rheumatology classification criteria or have a clinical diagnosis based on the expert opinion of the physician in charge. We calculated incidence rate using Poisson regression and assessed the influence of age, sex, geographical area and season.Results We identified 1675 cases of GCA with a mean age at diagnosis of 76.9 +/- 8.3 years. The annual incidence was estimated at 7.42 (95% CI 6.57 to 8.27) cases of GCA per 100 000 people >= 50 years with a peak for patients aged 80-84 years (23.06 (95% CI 20.89 to 25.4)). The incidence was greater in women (10.06 (95% CI 8.7 to 11.5)) than in men (4.83 (95% CI 3.8 to 5.9)). No significant differences were found between geographical distribution and incidence throughout the year (p=0.125). The phenotypes at diagnosis were cranial in 1091 patients, extracranial in 337 patients and mixed in 170 patients.Conclusions This is the first study to estimate the incidence of GCA in Spain at a national level. We found a predominance among women and during the ninth decade of life with no clear variability according to geographical area or seasons of the year.BMJ PUBLISHING GROUP2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17722http://ddd.uab.cat/record/305611RMD OpenISSN: 20565933reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p177222026-06-14T12:41:47Z
dc.title.none.fl_str_mv Incidence and clinical manifestations of giant cell arteritis in Spain: results of the ARTESER register
title Incidence and clinical manifestations of giant cell arteritis in Spain: results of the ARTESER register
spellingShingle Incidence and clinical manifestations of giant cell arteritis in Spain: results of the ARTESER register
Fernández-Lozano, D
epidemiology
incidence
giant cell arteritis
vasculitis
title_short Incidence and clinical manifestations of giant cell arteritis in Spain: results of the ARTESER register
title_full Incidence and clinical manifestations of giant cell arteritis in Spain: results of the ARTESER register
title_fullStr Incidence and clinical manifestations of giant cell arteritis in Spain: results of the ARTESER register
title_full_unstemmed Incidence and clinical manifestations of giant cell arteritis in Spain: results of the ARTESER register
title_sort Incidence and clinical manifestations of giant cell arteritis in Spain: results of the ARTESER register
dc.creator.none.fl_str_mv Fernández-Lozano, D
Hernández-Rodríguez, I
Narvaez, J
Domínguez-Alvaro, M
De Miguel, E
Silva-Díaz, M
Belzunegui, JM
Morales, CM
Sánchez, J
Galíndez-Agirregoikoa, E
Aldaroso, V
Abasolo, L
Loricera, J
Garrido-Puñal, N
Alvarado, PM
Larena, C
Navarro, VA
Calvet, J
Casafont-Solé, I
Ortiz-Sanjuán, F
Monte, TCS
Castañeda, S
Blanco, R
author Fernández-Lozano, D
author_facet Fernández-Lozano, D
Hernández-Rodríguez, I
Narvaez, J
Domínguez-Alvaro, M
De Miguel, E
Silva-Díaz, M
Belzunegui, JM
Morales, CM
Sánchez, J
Galíndez-Agirregoikoa, E
Aldaroso, V
Abasolo, L
Loricera, J
Garrido-Puñal, N
Alvarado, PM
Larena, C
Navarro, VA
Calvet, J
Casafont-Solé, I
Ortiz-Sanjuán, F
Monte, TCS
Castañeda, S
Blanco, R
author_role author
author2 Hernández-Rodríguez, I
Narvaez, J
Domínguez-Alvaro, M
De Miguel, E
Silva-Díaz, M
Belzunegui, JM
Morales, CM
Sánchez, J
Galíndez-Agirregoikoa, E
Aldaroso, V
Abasolo, L
Loricera, J
Garrido-Puñal, N
Alvarado, PM
Larena, C
Navarro, VA
Calvet, J
Casafont-Solé, I
Ortiz-Sanjuán, F
Monte, TCS
Castañeda, S
Blanco, R
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv epidemiology
incidence
giant cell arteritis
vasculitis
topic epidemiology
incidence
giant cell arteritis
vasculitis
description Objective This study aimed to estimate the incidence of giant cell arteritis (GCA) in Spain and to analyse its clinical manifestations, and distribution by age group, sex, geographical area and season.Methods We included all patients diagnosed with GCA between 1 June 2013 and 29 March 2019 at 26 hospitals of the National Health System. They had to be aged >= 50 years and have at least one positive results in an objective diagnostic test (biopsy or imaging techniques), meet 3/5 of the 1990 American College of Rheumatology classification criteria or have a clinical diagnosis based on the expert opinion of the physician in charge. We calculated incidence rate using Poisson regression and assessed the influence of age, sex, geographical area and season.Results We identified 1675 cases of GCA with a mean age at diagnosis of 76.9 +/- 8.3 years. The annual incidence was estimated at 7.42 (95% CI 6.57 to 8.27) cases of GCA per 100 000 people >= 50 years with a peak for patients aged 80-84 years (23.06 (95% CI 20.89 to 25.4)). The incidence was greater in women (10.06 (95% CI 8.7 to 11.5)) than in men (4.83 (95% CI 3.8 to 5.9)). No significant differences were found between geographical distribution and incidence throughout the year (p=0.125). The phenotypes at diagnosis were cranial in 1091 patients, extracranial in 337 patients and mixed in 170 patients.Conclusions This is the first study to estimate the incidence of GCA in Spain at a national level. We found a predominance among women and during the ninth decade of life with no clear variability according to geographical area or seasons of the year.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17722
http://ddd.uab.cat/record/305611
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=17722
http://ddd.uab.cat/record/305611
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMJ PUBLISHING GROUP
publisher.none.fl_str_mv BMJ PUBLISHING GROUP
dc.source.none.fl_str_mv RMD Open
ISSN: 20565933
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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