Association Between Telomere Length And Risk Of Cancer And Non-neoplastic Diseases: A Mendelian Randomization Study

Haycock, Philip C.; Burgess, Stephen; Nounu, Aayah; Zheng, Jie; Okoli, George N.; Bowden, Jack; Wade, Kaitlin H.; Timpson, Nicholas J.; Evans, David M.; Willeit, Peter; Aviv, Abraham; Litchfield, Kevin; Thompson, Philip J.; Ma, Shwu-Fan; Brown, W. Mark; Petukhova, Lynn; Zeng, Chenjie; Paternoster, Lavinia; Wolpin, Brian M.; Betz, Regina C.; Rotter, Jerome I.; Lee, Jeffrey E.; Svenson, Ulrika; Carreras-Torres, Robert; McKay, James D.; Arking, Dan E.; Hillary, Ryan P.; Ashar, Foram N.; Sotoodehnia, Nona; Freedman, Neal D.; Johansson, Mattias; Li, Yong; Aben, Katja K.; Low, Siew-Kee; Comeau, Mary E.; Taylor, Philip R.; Kubo, Michiaki; Hibberd, Martin Lloyd; Fan, Xing; Zhang, Xuejun; Zhu, Caihong; Sangiovanni, John Paul; Tumino, Rosario; Hunt, Steven; O'Mara, Tracy A.; Smith, George Davey; Ferreira, Manuel A.; Law, Matthew H.; Noth, Imre; Fogh, Isabella; Cotch, Mary Frances; Jensen, Richard A.; Munz, Matthias; Eeles, Rosalind A.; Hemani, Gibran; Gunter, Marc J.; Abnet, Christian C.; Trichopoulou, Antonia; Speliotes, Elizabeth; Spurdle, Amanda B.; Severi, Gianluca; Martin, Nicholas G.; Zheng, Wei; Iles, Mark M.; Shu, Xiao-Ou; Yang, Qiong; Reis, Andre; Kahali, Bratati; Uebe, Steffen; Garcia Barcelo, Mercè; Pooley, Karen A.; Stolzenberg-Solomon, Rachael Z.; Bown, Matthew J.; Kim, Jong-Won; Bracci, Paige M.; Kiemeney, Lambertus A. L. M.; Samani, Nilesh J.; Bei, Jin-Xin; Zeng, Yi-Xin; Wong, Tien Yin; Försti, Asta; Chen, Wei V.; Kurian, Kathreena M.; Chen, Bowang; Wade, Tracey D.; Ellinghaus, David; Cha, Pei-Chieng; Fang, Shenying; Baas, Annette F.; Overvad, Kim; Nakamura, Yusuke; Elmore, James R.; Klein, Alison P.; Ellis, Hayley Patricia; Cox, David G.; Delattre, Olivier; Bowdler, Lisa M.; Mirabeau, Olivier; Ollila, Hanna M.; Thompson, Deborah J.; Skibola, Christine F.; Cheng, Ching-Yu; Brennan, Paul; Soranzo, Nicole; Lin, Kuang; Telomeres Mendelian Randomization Collaboration; Tang, Clara S.; Vermeulen, Sita H.; Powell, John F.; Worrall, Bradford B.; Montgomery, Grant W.; Morrison, Alanna C.; Mangino, Massimo; Levy, Daniel; Amundadottir, Laufey; Kimura, Masayuki; Hwang, Shih-Jen; Spector, Tim D.; Neale, Rachel E.; Onland-Moret, N. Charlotte; Woo, Daniel; Sasaki, Tsukasa; Flores, Carlos; Fischer, Annegret; Rij, Andre Van; Rice, Kenneth; Relton, Caroline L.; Martin, Richard M.; Su, Wen-Hui; Franke, Andre; Barr, Graham; Gordon, Scott; Yerges-Armstrong, Laura M.; Gaunt, Tom R.; Chang, Yu-Sun; Nyholt, Dale R.; Gaborieau, Valérie; Markus, Hugh Stephen; Hung, Rayjean J.; Amos, Christopher I.; Manichaikul, Ani W.; Otowa, Takeshi; Rosand, Jonathan; Han, Fang; Langefeld, Carl D.; Dommisch, Henrik; Wang, Feijie; Maris, John M.; Christiano, Angela M.; Lund, Eiliv; Duell, Eric J.; Canzian, Federico; Mijatovic, Vladan; Han, Jiali; Kawamura, Yoshiya; Chang, Kai-Ping; Ralston, Stuart H.; Hui, Jennie; Xie, Gang; Foo, Jia Nee; Sapkota, Yadav; T'hof, Femke N.G. van; Schwartz, David A.; Tromp, Gerard; Fingerlin, Tasha E.; Jones, Gregory T.; Cho, Michael H.; Kuivaniemi, Helena; Scelo, Ghislaine; Wiencke, John K.; Albagha, Omar; Schaefer, Arne S.; Walsh, Kyle M.; Hüffmeier, Ulrike; Landi, Stefano; Hokanson, John E.; Olson, Sara H.; Gallinger, Steven; Smith, Nicholas L.; Li, Donghui; Thompson, Susan D.; Petersen, Gloria M.; Risch, Harvey A.; Zondervan, Krina T.; Abecasis, Gonçalo R.; Heel, David A. van; Felix, Janine F.; Davila, Sonia; Liu, Jianjun; Hunt, Karen; Lee, Chaeyoung; Jonas, Jost B.; Silverman, Edwin K.; Wrensch, Margaret; Rice, Terri; Lin, Xu; Turnbull, Clare; Standl, Marie; Siminovitch, Katherine

Association Between Telomere Length And Risk Of Cancer And Non-neoplastic Diseases: A Mendelian Randomization Study

IMPORTANCE The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. OBJECTIVE To conduct a Mendelian randomization study, u...

Descripción completa

Detalles Bibliográficos
Autores:	Haycock, Philip C., Burgess, Stephen, Nounu, Aayah, Zheng, Jie, Okoli, George N., Bowden, Jack, Wade, Kaitlin H., Timpson, Nicholas J., Evans, David M., Willeit, Peter, Aviv, Abraham, Litchfield, Kevin, Thompson, Philip J., Ma, Shwu-Fan, Brown, W. Mark, Petukhova, Lynn, Zeng, Chenjie, Paternoster, Lavinia, Wolpin, Brian M., Betz, Regina C., Rotter, Jerome I., Lee, Jeffrey E., Svenson, Ulrika, Carreras-Torres, Robert, McKay, James D., Arking, Dan E., Hillary, Ryan P., Ashar, Foram N., Sotoodehnia, Nona, Freedman, Neal D., Johansson, Mattias, Li, Yong, Aben, Katja K., Low, Siew-Kee, Comeau, Mary E., Taylor, Philip R., Kubo, Michiaki, Hibberd, Martin Lloyd, Fan, Xing, Zhang, Xuejun, Zhu, Caihong, Sangiovanni, John Paul, Tumino, Rosario, Hunt, Steven, O'Mara, Tracy A., Smith, George Davey, Ferreira, Manuel A., Law, Matthew H., Noth, Imre, Fogh, Isabella, Cotch, Mary Frances, Jensen, Richard A., Munz, Matthias, Eeles, Rosalind A., Hemani, Gibran, Gunter, Marc J., Abnet, Christian C., Trichopoulou, Antonia, Speliotes, Elizabeth, Spurdle, Amanda B., Severi, Gianluca, Martin, Nicholas G., Zheng, Wei, Iles, Mark M., Shu, Xiao-Ou, Yang, Qiong, Reis, Andre, Kahali, Bratati, Uebe, Steffen, Garcia Barcelo, Mercè, Pooley, Karen A., Stolzenberg-Solomon, Rachael Z., Bown, Matthew J., Kim, Jong-Won, Bracci, Paige M., Kiemeney, Lambertus A. L. M., Samani, Nilesh J., Bei, Jin-Xin, Zeng, Yi-Xin, Wong, Tien Yin, Försti, Asta, Chen, Wei V., Kurian, Kathreena M., Chen, Bowang, Wade, Tracey D., Ellinghaus, David, Cha, Pei-Chieng, Fang, Shenying, Baas, Annette F., Overvad, Kim, Nakamura, Yusuke, Elmore, James R., Klein, Alison P., Ellis, Hayley Patricia, Cox, David G., Delattre, Olivier, Bowdler, Lisa M., Mirabeau, Olivier, Ollila, Hanna M., Thompson, Deborah J., Skibola, Christine F., Cheng, Ching-Yu, Brennan, Paul, Soranzo, Nicole, Lin, Kuang, Telomeres Mendelian Randomization Collaboration, Tang, Clara S., Vermeulen, Sita H., Powell, John F., Worrall, Bradford B., Montgomery, Grant W., Morrison, Alanna C., Mangino, Massimo, Levy, Daniel, Amundadottir, Laufey, Kimura, Masayuki, Hwang, Shih-Jen, Spector, Tim D., Neale, Rachel E., Onland-Moret, N. Charlotte, Woo, Daniel, Sasaki, Tsukasa, Flores, Carlos, Fischer, Annegret, Rij, Andre Van, Rice, Kenneth, Relton, Caroline L., Martin, Richard M., Su, Wen-Hui, Franke, Andre, Barr, Graham, Gordon, Scott, Yerges-Armstrong, Laura M., Gaunt, Tom R., Chang, Yu-Sun, Nyholt, Dale R., Gaborieau, Valérie, Markus, Hugh Stephen, Hung, Rayjean J., Amos, Christopher I., Manichaikul, Ani W., Otowa, Takeshi, Rosand, Jonathan, Han, Fang, Langefeld, Carl D., Dommisch, Henrik, Wang, Feijie, Maris, John M., Christiano, Angela M., Lund, Eiliv, Duell, Eric J., Canzian, Federico, Mijatovic, Vladan, Han, Jiali, Kawamura, Yoshiya, Chang, Kai-Ping, Ralston, Stuart H., Hui, Jennie, Xie, Gang, Foo, Jia Nee, Sapkota, Yadav, T'hof, Femke N.G. van, Schwartz, David A., Tromp, Gerard, Fingerlin, Tasha E., Jones, Gregory T., Cho, Michael H., Kuivaniemi, Helena, Scelo, Ghislaine, Wiencke, John K., Albagha, Omar, Schaefer, Arne S., Walsh, Kyle M., Hüffmeier, Ulrike, Landi, Stefano, Hokanson, John E., Olson, Sara H., Gallinger, Steven, Smith, Nicholas L., Li, Donghui, Thompson, Susan D., Petersen, Gloria M., Risch, Harvey A., Zondervan, Krina T., Abecasis, Gonçalo R., Heel, David A. van, Felix, Janine F., Davila, Sonia, Liu, Jianjun, Hunt, Karen, Lee, Chaeyoung, Jonas, Jost B., Silverman, Edwin K., Wrensch, Margaret, Rice, Terri, Lin, Xu, Turnbull, Clare, Standl, Marie, Siminovitch, Katherine
Tipo de recurso:	artículo
Estado:	Versión aceptada para publicación
Fecha de publicación:	2017
País:	España
Institución:	Universidad de Barcelona
Repositorio:	Dipòsit Digital de la UB
OAI Identifier:	oai:diposit.ub.edu:2445/124398
Acceso en línea:	https://hdl.handle.net/2445/124398
Access Level:	acceso abierto
Palabra clave:	Nucleòtids Càncer Nucleotides Cancer

id	ES_cac8c81beda0bdb2e83889e0cd69fa3b
oai_identifier_str	oai:diposit.ub.edu:2445/124398
network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	Association Between Telomere Length And Risk Of Cancer And Non-neoplastic Diseases: A Mendelian Randomization Study
title	Association Between Telomere Length And Risk Of Cancer And Non-neoplastic Diseases: A Mendelian Randomization Study
spellingShingle	Association Between Telomere Length And Risk Of Cancer And Non-neoplastic Diseases: A Mendelian Randomization Study Haycock, Philip C. Nucleòtids Càncer Nucleotides Cancer
title_short	Association Between Telomere Length And Risk Of Cancer And Non-neoplastic Diseases: A Mendelian Randomization Study
title_full	Association Between Telomere Length And Risk Of Cancer And Non-neoplastic Diseases: A Mendelian Randomization Study
title_fullStr	Association Between Telomere Length And Risk Of Cancer And Non-neoplastic Diseases: A Mendelian Randomization Study
title_full_unstemmed	Association Between Telomere Length And Risk Of Cancer And Non-neoplastic Diseases: A Mendelian Randomization Study
title_sort	Association Between Telomere Length And Risk Of Cancer And Non-neoplastic Diseases: A Mendelian Randomization Study
dc.creator.none.fl_str_mv	Haycock, Philip C. Burgess, Stephen Nounu, Aayah Zheng, Jie Okoli, George N. Bowden, Jack Wade, Kaitlin H. Timpson, Nicholas J. Evans, David M. Willeit, Peter Aviv, Abraham Litchfield, Kevin Thompson, Philip J. Ma, Shwu-Fan Brown, W. Mark Petukhova, Lynn Zeng, Chenjie Paternoster, Lavinia Wolpin, Brian M. Betz, Regina C. Rotter, Jerome I. Lee, Jeffrey E. Svenson, Ulrika Carreras-Torres, Robert McKay, James D. Arking, Dan E. Hillary, Ryan P. Ashar, Foram N. Sotoodehnia, Nona Freedman, Neal D. Johansson, Mattias Li, Yong Aben, Katja K. Low, Siew-Kee Comeau, Mary E. Taylor, Philip R. Kubo, Michiaki Hibberd, Martin Lloyd Fan, Xing Zhang, Xuejun Zhu, Caihong Sangiovanni, John Paul Tumino, Rosario Hunt, Steven O'Mara, Tracy A. Smith, George Davey Ferreira, Manuel A. Law, Matthew H. Noth, Imre Fogh, Isabella Cotch, Mary Frances Jensen, Richard A. Munz, Matthias Eeles, Rosalind A. Hemani, Gibran Gunter, Marc J. Abnet, Christian C. Trichopoulou, Antonia Speliotes, Elizabeth Spurdle, Amanda B. Severi, Gianluca Martin, Nicholas G. Zheng, Wei Iles, Mark M. Shu, Xiao-Ou Yang, Qiong Reis, Andre Kahali, Bratati Uebe, Steffen Garcia Barcelo, Mercè Pooley, Karen A. Stolzenberg-Solomon, Rachael Z. Bown, Matthew J. Kim, Jong-Won Bracci, Paige M. Kiemeney, Lambertus A. L. M. Samani, Nilesh J. Bei, Jin-Xin Zeng, Yi-Xin Wong, Tien Yin Försti, Asta Chen, Wei V. Kurian, Kathreena M. Chen, Bowang Wade, Tracey D. Ellinghaus, David Cha, Pei-Chieng Fang, Shenying Baas, Annette F. Overvad, Kim Nakamura, Yusuke Elmore, James R. Klein, Alison P. Ellis, Hayley Patricia Cox, David G. Delattre, Olivier Bowdler, Lisa M. Mirabeau, Olivier Ollila, Hanna M. Thompson, Deborah J. Skibola, Christine F. Cheng, Ching-Yu Brennan, Paul Soranzo, Nicole Lin, Kuang Telomeres Mendelian Randomization Collaboration Tang, Clara S. Vermeulen, Sita H. Powell, John F. Worrall, Bradford B. Montgomery, Grant W. Morrison, Alanna C. Mangino, Massimo Levy, Daniel Amundadottir, Laufey Kimura, Masayuki Hwang, Shih-Jen Spector, Tim D. Neale, Rachel E. Onland-Moret, N. Charlotte Woo, Daniel Sasaki, Tsukasa Flores, Carlos Fischer, Annegret Rij, Andre Van Rice, Kenneth Relton, Caroline L. Martin, Richard M. Su, Wen-Hui Franke, Andre Barr, Graham Gordon, Scott Yerges-Armstrong, Laura M. Gaunt, Tom R. Chang, Yu-Sun Nyholt, Dale R. Gaborieau, Valérie Markus, Hugh Stephen Hung, Rayjean J. Amos, Christopher I. Manichaikul, Ani W. Otowa, Takeshi Rosand, Jonathan Han, Fang Langefeld, Carl D. Dommisch, Henrik Wang, Feijie Maris, John M. Christiano, Angela M. Lund, Eiliv Duell, Eric J. Canzian, Federico Mijatovic, Vladan Han, Jiali Kawamura, Yoshiya Chang, Kai-Ping Ralston, Stuart H. Hui, Jennie Xie, Gang Foo, Jia Nee Sapkota, Yadav T'hof, Femke N.G. van Schwartz, David A. Tromp, Gerard Fingerlin, Tasha E. Jones, Gregory T. Cho, Michael H. Kuivaniemi, Helena Scelo, Ghislaine Wiencke, John K. Albagha, Omar Schaefer, Arne S. Walsh, Kyle M. Hüffmeier, Ulrike Landi, Stefano Hokanson, John E. Olson, Sara H. Gallinger, Steven Smith, Nicholas L. Li, Donghui Thompson, Susan D. Petersen, Gloria M. Risch, Harvey A. Zondervan, Krina T. Abecasis, Gonçalo R. Heel, David A. van Felix, Janine F. Davila, Sonia Liu, Jianjun Hunt, Karen Lee, Chaeyoung Jonas, Jost B. Silverman, Edwin K. Wrensch, Margaret Rice, Terri Lin, Xu Turnbull, Clare Standl, Marie Siminovitch, Katherine
author	Haycock, Philip C.
author_facet	Haycock, Philip C. Burgess, Stephen Nounu, Aayah Zheng, Jie Okoli, George N. Bowden, Jack Wade, Kaitlin H. Timpson, Nicholas J. Evans, David M. Willeit, Peter Aviv, Abraham Litchfield, Kevin Thompson, Philip J. Ma, Shwu-Fan Brown, W. Mark Petukhova, Lynn Zeng, Chenjie Paternoster, Lavinia Wolpin, Brian M. Betz, Regina C. Rotter, Jerome I. Lee, Jeffrey E. Svenson, Ulrika Carreras-Torres, Robert McKay, James D. Arking, Dan E. Hillary, Ryan P. Ashar, Foram N. Sotoodehnia, Nona Freedman, Neal D. Johansson, Mattias Li, Yong Aben, Katja K. Low, Siew-Kee Comeau, Mary E. Taylor, Philip R. Kubo, Michiaki Hibberd, Martin Lloyd Fan, Xing Zhang, Xuejun Zhu, Caihong Sangiovanni, John Paul Tumino, Rosario Hunt, Steven O'Mara, Tracy A. Smith, George Davey Ferreira, Manuel A. Law, Matthew H. Noth, Imre Fogh, Isabella Cotch, Mary Frances Jensen, Richard A. Munz, Matthias Eeles, Rosalind A. Hemani, Gibran Gunter, Marc J. Abnet, Christian C. Trichopoulou, Antonia Speliotes, Elizabeth Spurdle, Amanda B. Severi, Gianluca Martin, Nicholas G. Zheng, Wei Iles, Mark M. Shu, Xiao-Ou Yang, Qiong Reis, Andre Kahali, Bratati Uebe, Steffen Garcia Barcelo, Mercè Pooley, Karen A. Stolzenberg-Solomon, Rachael Z. Bown, Matthew J. Kim, Jong-Won Bracci, Paige M. Kiemeney, Lambertus A. L. M. Samani, Nilesh J. Bei, Jin-Xin Zeng, Yi-Xin Wong, Tien Yin Försti, Asta Chen, Wei V. Kurian, Kathreena M. Chen, Bowang Wade, Tracey D. Ellinghaus, David Cha, Pei-Chieng Fang, Shenying Baas, Annette F. Overvad, Kim Nakamura, Yusuke Elmore, James R. Klein, Alison P. Ellis, Hayley Patricia Cox, David G. Delattre, Olivier Bowdler, Lisa M. Mirabeau, Olivier Ollila, Hanna M. Thompson, Deborah J. Skibola, Christine F. Cheng, Ching-Yu Brennan, Paul Soranzo, Nicole Lin, Kuang Telomeres Mendelian Randomization Collaboration Tang, Clara S. Vermeulen, Sita H. Powell, John F. Worrall, Bradford B. Montgomery, Grant W. Morrison, Alanna C. Mangino, Massimo Levy, Daniel Amundadottir, Laufey Kimura, Masayuki Hwang, Shih-Jen Spector, Tim D. Neale, Rachel E. Onland-Moret, N. Charlotte Woo, Daniel Sasaki, Tsukasa Flores, Carlos Fischer, Annegret Rij, Andre Van Rice, Kenneth Relton, Caroline L. Martin, Richard M. Su, Wen-Hui Franke, Andre Barr, Graham Gordon, Scott Yerges-Armstrong, Laura M. Gaunt, Tom R. Chang, Yu-Sun Nyholt, Dale R. Gaborieau, Valérie Markus, Hugh Stephen Hung, Rayjean J. Amos, Christopher I. Manichaikul, Ani W. Otowa, Takeshi Rosand, Jonathan Han, Fang Langefeld, Carl D. Dommisch, Henrik Wang, Feijie Maris, John M. Christiano, Angela M. Lund, Eiliv Duell, Eric J. Canzian, Federico Mijatovic, Vladan Han, Jiali Kawamura, Yoshiya Chang, Kai-Ping Ralston, Stuart H. Hui, Jennie Xie, Gang Foo, Jia Nee Sapkota, Yadav T'hof, Femke N.G. van Schwartz, David A. Tromp, Gerard Fingerlin, Tasha E. Jones, Gregory T. Cho, Michael H. Kuivaniemi, Helena Scelo, Ghislaine Wiencke, John K. Albagha, Omar Schaefer, Arne S. Walsh, Kyle M. Hüffmeier, Ulrike Landi, Stefano Hokanson, John E. Olson, Sara H. Gallinger, Steven Smith, Nicholas L. Li, Donghui Thompson, Susan D. Petersen, Gloria M. Risch, Harvey A. Zondervan, Krina T. Abecasis, Gonçalo R. Heel, David A. van Felix, Janine F. Davila, Sonia Liu, Jianjun Hunt, Karen Lee, Chaeyoung Jonas, Jost B. Silverman, Edwin K. Wrensch, Margaret Rice, Terri Lin, Xu Turnbull, Clare Standl, Marie Siminovitch, Katherine
author_role	author
author2	Burgess, Stephen Nounu, Aayah Zheng, Jie Okoli, George N. Bowden, Jack Wade, Kaitlin H. Timpson, Nicholas J. Evans, David M. Willeit, Peter Aviv, Abraham Litchfield, Kevin Thompson, Philip J. Ma, Shwu-Fan Brown, W. Mark Petukhova, Lynn Zeng, Chenjie Paternoster, Lavinia Wolpin, Brian M. Betz, Regina C. Rotter, Jerome I. Lee, Jeffrey E. Svenson, Ulrika Carreras-Torres, Robert McKay, James D. Arking, Dan E. Hillary, Ryan P. Ashar, Foram N. Sotoodehnia, Nona Freedman, Neal D. Johansson, Mattias Li, Yong Aben, Katja K. Low, Siew-Kee Comeau, Mary E. Taylor, Philip R. Kubo, Michiaki Hibberd, Martin Lloyd Fan, Xing Zhang, Xuejun Zhu, Caihong Sangiovanni, John Paul Tumino, Rosario Hunt, Steven O'Mara, Tracy A. Smith, George Davey Ferreira, Manuel A. Law, Matthew H. Noth, Imre Fogh, Isabella Cotch, Mary Frances Jensen, Richard A. Munz, Matthias Eeles, Rosalind A. Hemani, Gibran Gunter, Marc J. Abnet, Christian C. Trichopoulou, Antonia Speliotes, Elizabeth Spurdle, Amanda B. Severi, Gianluca Martin, Nicholas G. Zheng, Wei Iles, Mark M. Shu, Xiao-Ou Yang, Qiong Reis, Andre Kahali, Bratati Uebe, Steffen Garcia Barcelo, Mercè Pooley, Karen A. Stolzenberg-Solomon, Rachael Z. Bown, Matthew J. Kim, Jong-Won Bracci, Paige M. Kiemeney, Lambertus A. L. M. Samani, Nilesh J. Bei, Jin-Xin Zeng, Yi-Xin Wong, Tien Yin Försti, Asta Chen, Wei V. Kurian, Kathreena M. Chen, Bowang Wade, Tracey D. Ellinghaus, David Cha, Pei-Chieng Fang, Shenying Baas, Annette F. Overvad, Kim Nakamura, Yusuke Elmore, James R. Klein, Alison P. Ellis, Hayley Patricia Cox, David G. Delattre, Olivier Bowdler, Lisa M. Mirabeau, Olivier Ollila, Hanna M. Thompson, Deborah J. Skibola, Christine F. Cheng, Ching-Yu Brennan, Paul Soranzo, Nicole Lin, Kuang Telomeres Mendelian Randomization Collaboration Tang, Clara S. Vermeulen, Sita H. Powell, John F. Worrall, Bradford B. Montgomery, Grant W. Morrison, Alanna C. Mangino, Massimo Levy, Daniel Amundadottir, Laufey Kimura, Masayuki Hwang, Shih-Jen Spector, Tim D. Neale, Rachel E. Onland-Moret, N. Charlotte Woo, Daniel Sasaki, Tsukasa Flores, Carlos Fischer, Annegret Rij, Andre Van Rice, Kenneth Relton, Caroline L. Martin, Richard M. Su, Wen-Hui Franke, Andre Barr, Graham Gordon, Scott Yerges-Armstrong, Laura M. Gaunt, Tom R. Chang, Yu-Sun Nyholt, Dale R. Gaborieau, Valérie Markus, Hugh Stephen Hung, Rayjean J. Amos, Christopher I. Manichaikul, Ani W. Otowa, Takeshi Rosand, Jonathan Han, Fang Langefeld, Carl D. Dommisch, Henrik Wang, Feijie Maris, John M. Christiano, Angela M. Lund, Eiliv Duell, Eric J. Canzian, Federico Mijatovic, Vladan Han, Jiali Kawamura, Yoshiya Chang, Kai-Ping Ralston, Stuart H. Hui, Jennie Xie, Gang Foo, Jia Nee Sapkota, Yadav T'hof, Femke N.G. van Schwartz, David A. Tromp, Gerard Fingerlin, Tasha E. Jones, Gregory T. Cho, Michael H. Kuivaniemi, Helena Scelo, Ghislaine Wiencke, John K. Albagha, Omar Schaefer, Arne S. Walsh, Kyle M. Hüffmeier, Ulrike Landi, Stefano Hokanson, John E. Olson, Sara H. Gallinger, Steven Smith, Nicholas L. Li, Donghui Thompson, Susan D. Petersen, Gloria M. Risch, Harvey A. Zondervan, Krina T. Abecasis, Gonçalo R. Heel, David A. van Felix, Janine F. Davila, Sonia Liu, Jianjun Hunt, Karen Lee, Chaeyoung Jonas, Jost B. Silverman, Edwin K. Wrensch, Margaret Rice, Terri Lin, Xu Turnbull, Clare Standl, Marie Siminovitch, Katherine
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Nucleòtids Càncer Nucleotides Cancer
topic	Nucleòtids Càncer Nucleotides Cancer
description	IMPORTANCE The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. OBJECTIVE To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. DATA SOURCES Genomewide association studies (GWAS) published up to January 15, 2015. STUDY SELECTION GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available. DATA EXTRACTION AND SYNTHESIS Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population. MAIN OUTCOMES AND MEASURES Odds ratios (ORs) and 95% confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation. RESULTS Summary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [ 95% CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. There was generally little evidence of association between genetically increased telomere length and risk of psychiatric, autoimmune, inflammatory, diabetic, and other non-neoplastic diseases, except for coronary heart disease (OR, 0.78 [ 95% CI, 0.67-0.90]), abdominal aortic aneurysm (OR, 0.63 [ 95% CI, 0.49-0.81]), celiac disease (OR, 0.42 [ 95% CI, 0.28-0.61]) and interstitial lung disease (OR, 0.09 [ 95% CI, 0.05-0.15]). CONCLUSIONS AND RELEVANCE It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases.
publishDate	2017
dc.date.none.fl_str_mv	2017
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion
format	article
status_str	acceptedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/124398
url	https://hdl.handle.net/2445/124398
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Versió postprint del document publicat a: https://doi.org/10.1001/jamaoncol.2016.5945 Jama Oncology, 2017, vol. 3, num. 5, p. 636-651 https://doi.org/10.1001/jamaoncol.2016.5945
dc.rights.none.fl_str_mv	(c) American Medical Association, 2017 info:eu-repo/semantics/openAccess
rights_invalid_str_mv	(c) American Medical Association, 2017
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	American Medical Association
publisher.none.fl_str_mv	American Medical Association
dc.source.none.fl_str_mv	Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona
instname_str	Universidad de Barcelona
reponame_str	Dipòsit Digital de la UB
collection	Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869419509818851328
spelling	Association Between Telomere Length And Risk Of Cancer And Non-neoplastic Diseases: A Mendelian Randomization StudyHaycock, Philip C.Burgess, StephenNounu, AayahZheng, JieOkoli, George N.Bowden, JackWade, Kaitlin H.Timpson, Nicholas J.Evans, David M.Willeit, PeterAviv, AbrahamLitchfield, KevinThompson, Philip J.Ma, Shwu-FanBrown, W. MarkPetukhova, LynnZeng, ChenjiePaternoster, LaviniaWolpin, Brian M.Betz, Regina C.Rotter, Jerome I.Lee, Jeffrey E.Svenson, UlrikaCarreras-Torres, RobertMcKay, James D.Arking, Dan E.Hillary, Ryan P.Ashar, Foram N.Sotoodehnia, NonaFreedman, Neal D.Johansson, MattiasLi, YongAben, Katja K.Low, Siew-KeeComeau, Mary E.Taylor, Philip R.Kubo, MichiakiHibberd, Martin LloydFan, XingZhang, XuejunZhu, CaihongSangiovanni, John PaulTumino, RosarioHunt, StevenO'Mara, Tracy A.Smith, George DaveyFerreira, Manuel A.Law, Matthew H.Noth, ImreFogh, IsabellaCotch, Mary FrancesJensen, Richard A.Munz, MatthiasEeles, Rosalind A.Hemani, GibranGunter, Marc J.Abnet, Christian C.Trichopoulou, AntoniaSpeliotes, ElizabethSpurdle, Amanda B.Severi, GianlucaMartin, Nicholas G.Zheng, WeiIles, Mark M.Shu, Xiao-OuYang, QiongReis, AndreKahali, BratatiUebe, SteffenGarcia Barcelo, MercèPooley, Karen A.Stolzenberg-Solomon, Rachael Z.Bown, Matthew J.Kim, Jong-WonBracci, Paige M.Kiemeney, Lambertus A. L. M.Samani, Nilesh J.Bei, Jin-XinZeng, Yi-XinWong, Tien YinFörsti, AstaChen, Wei V.Kurian, Kathreena M.Chen, BowangWade, Tracey D.Ellinghaus, DavidCha, Pei-ChiengFang, ShenyingBaas, Annette F.Overvad, KimNakamura, YusukeElmore, James R.Klein, Alison P.Ellis, Hayley PatriciaCox, David G.Delattre, OlivierBowdler, Lisa M.Mirabeau, OlivierOllila, Hanna M.Thompson, Deborah J.Skibola, Christine F.Cheng, Ching-YuBrennan, PaulSoranzo, NicoleLin, KuangTelomeres Mendelian Randomization CollaborationTang, Clara S.Vermeulen, Sita H.Powell, John F.Worrall, Bradford B.Montgomery, Grant W.Morrison, Alanna C.Mangino, MassimoLevy, DanielAmundadottir, LaufeyKimura, MasayukiHwang, Shih-JenSpector, Tim D.Neale, Rachel E.Onland-Moret, N. CharlotteWoo, DanielSasaki, TsukasaFlores, CarlosFischer, AnnegretRij, Andre VanRice, KennethRelton, Caroline L.Martin, Richard M.Su, Wen-HuiFranke, AndreBarr, GrahamGordon, ScottYerges-Armstrong, Laura M.Gaunt, Tom R.Chang, Yu-SunNyholt, Dale R.Gaborieau, ValérieMarkus, Hugh StephenHung, Rayjean J.Amos, Christopher I.Manichaikul, Ani W.Otowa, TakeshiRosand, JonathanHan, FangLangefeld, Carl D.Dommisch, HenrikWang, FeijieMaris, John M.Christiano, Angela M.Lund, EilivDuell, Eric J.Canzian, FedericoMijatovic, VladanHan, JialiKawamura, YoshiyaChang, Kai-PingRalston, Stuart H.Hui, JennieXie, GangFoo, Jia NeeSapkota, YadavT'hof, Femke N.G. vanSchwartz, David A.Tromp, GerardFingerlin, Tasha E.Jones, Gregory T.Cho, Michael H.Kuivaniemi, HelenaScelo, GhislaineWiencke, John K.Albagha, OmarSchaefer, Arne S.Walsh, Kyle M.Hüffmeier, UlrikeLandi, StefanoHokanson, John E.Olson, Sara H.Gallinger, StevenSmith, Nicholas L.Li, DonghuiThompson, Susan D.Petersen, Gloria M.Risch, Harvey A.Zondervan, Krina T.Abecasis, Gonçalo R.Heel, David A. vanFelix, Janine F.Davila, SoniaLiu, JianjunHunt, KarenLee, ChaeyoungJonas, Jost B.Silverman, Edwin K.Wrensch, MargaretRice, TerriLin, XuTurnbull, ClareStandl, MarieSiminovitch, KatherineNucleòtidsCàncerNucleotidesCancerIMPORTANCE The causal direction and magnitude of the association between telomere length and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility of observational studies to confounding and reverse causation. OBJECTIVE To conduct a Mendelian randomization study, using germline genetic variants as instrumental variables, to appraise the causal relevance of telomere length for risk of cancer and non-neoplastic diseases. DATA SOURCES Genomewide association studies (GWAS) published up to January 15, 2015. STUDY SELECTION GWAS of noncommunicable diseases that assayed germline genetic variation and did not select cohort or control participants on the basis of preexisting diseases. Of 163 GWAS of noncommunicable diseases identified, summary data from 103 were available. DATA EXTRACTION AND SYNTHESIS Summary association statistics for single nucleotide polymorphisms (SNPs) that are strongly associated with telomere length in the general population. MAIN OUTCOMES AND MEASURES Odds ratios (ORs) and 95% confidence intervals (CIs) for disease per standard deviation (SD) higher telomere length due to germline genetic variation. RESULTS Summary data were available for 35 cancers and 48 non-neoplastic diseases, corresponding to 420 081 cases (median cases, 2526 per disease) and 1 093 105 controls (median, 6789 per disease). Increased telomere length due to germline genetic variation was generally associated with increased risk for site-specific cancers. The strongest associations (ORs [ 95% CIs] per 1-SD change in genetically increased telomere length) were observed for glioma, 5.27 (3.15-8.81); serous low-malignant-potential ovarian cancer, 4.35 (2.39-7.94); lung adenocarcinoma, 3.19 (2.40-4.22); neuroblastoma, 2.98 (1.92-4.62); bladder cancer, 2.19 (1.32-3.66); melanoma, 1.87 (1.55-2.26); testicular cancer, 1.76 (1.02-3.04); kidney cancer, 1.55 (1.08-2.23); and endometrial cancer, 1.31 (1.07-1.61). Associations were stronger for rarer cancers and at tissue sites with lower rates of stem cell division. There was generally little evidence of association between genetically increased telomere length and risk of psychiatric, autoimmune, inflammatory, diabetic, and other non-neoplastic diseases, except for coronary heart disease (OR, 0.78 [ 95% CI, 0.67-0.90]), abdominal aortic aneurysm (OR, 0.63 [ 95% CI, 0.49-0.81]), celiac disease (OR, 0.42 [ 95% CI, 0.28-0.61]) and interstitial lung disease (OR, 0.09 [ 95% CI, 0.05-0.15]). CONCLUSIONS AND RELEVANCE It is likely that longer telomeres increase risk for several cancers but reduce risk for some non-neoplastic diseases, including cardiovascular diseases.American Medical Association2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/124398Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1001/jamaoncol.2016.5945Jama Oncology, 2017, vol. 3, num. 5, p. 636-651https://doi.org/10.1001/jamaoncol.2016.5945(c) American Medical Association, 2017info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1243982026-05-27T06:46:51Z
score	15.300719

Association Between Telomere Length And Risk Of Cancer And Non-neoplastic Diseases: A Mendelian Randomization Study

Similares en LA Referencia