Validation of a simple screening tool for early diagnosis of advanced Parkinson's disease in daily practice: the CDEPA questionnaire
Early clinical diagnosis of advanced Parkinson’s disease (APD) may be difficult. This study aimed to validate a simple screening tool, the CDEPA questionnaire (“Cuestionario De Enfermedad de Parkinson Avanzada” [Questionnaire for Advanced Parkinson’s Disease]), for the identification of APD in daily...
| Autores: | , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2018 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/65649 |
| Acceso en línea: | https://hdl.handle.net/10171/65649 |
| Access Level: | acceso abierto |
| Palabra clave: | Advanced Parkinson-™s disease (APD) Hoehn and Yahr (HY) scale Neurología |
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Validation of a simple screening tool for early diagnosis of advanced Parkinson's disease in daily practice: the CDEPA questionnaireMartinez-Martin, P. (Pablo)|||/items/eaea88d2-7b1b-4d23-aa23-33fa883fae3cKulisevsky, J. (Jaime)|||/items/b2ecf863-734d-4e63-9198-4be17e3a25b3Mir, P. (Pablo)|||/items/46c80c86-091d-4e75-bad9-ad94c5f65840Tolosa, E. (Eduardo)|||/items/9a0e81d1-14a4-46b3-86d8-b071e8306d2fGarcía-Delgado, P. (Pilar)|||/items/93524a2e-b067-4629-aa3a-5d31f86d1774Luquin-Piudo, M.R. (María Rosario)|||/items/6449c359-8b33-4ca4-9ff1-ca1505be7ed3Advanced Parkinson-™s disease (APD)Hoehn and Yahr (HY) scaleNeurologíaEarly clinical diagnosis of advanced Parkinson’s disease (APD) may be difficult. This study aimed to validate a simple screening tool, the CDEPA questionnaire (“Cuestionario De Enfermedad de Parkinson Avanzada” [Questionnaire for Advanced Parkinson’s Disease]), for the identification of APD in daily practice. The study included 173 consecutively selected patients with PD (40% were women, mean age was 68.4 ± 10.5 years), stratified according to the Hoehn and Yahr (HY) scale. The CDEPA questionnaire defined APD as the presence of severe disability requiring help for activities of daily living (ADL), motor fluctuations with limitation or inability to perform ADL, severe dysphagia, recurrent falls, or dementia. The diagnostic performance of the questionnaire was assessed against the gold standard criterion based on clinical judgment. PD was categorized as advanced in 65 (38%) patients when using the gold standard and in 109 (63%) patients when the CDEPA questionnaire was used. The CDEPA questionnaire and the gold standard agreed moderately (kappa statistic of 0.48, P < 0.001). The CDEPA classified APD with a sensitivity of 97%; specificity of 57%; total accuracy of 72.3%; and area under the curve (for a binary classifier) of 77.2%. Significant differences were found between the groups created by the CDEPA in several usual PD evaluations (HY Scale, SCOPA Motor Scale, Non-motor Symptoms Scale for PD, Clinical Impression of Severity Index for PD, Clinical Global Impression–Severity Scale, and Patient Global Impression–Severity Scale). CDEPA showed satisfactory inter-rater agreement (kappa = 0.88) and test–retest concordance (kappa 0.83). In conclusion, the CDEPA questionnaire is a valid, reliable, and useful instrument for easily screening APD.Nature ResearchDadun. Depósito Académico Digital Universidad de Navarra20232023-03-0920182018-01-0120182018-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/65649reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/656492026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Validation of a simple screening tool for early diagnosis of advanced Parkinson's disease in daily practice: the CDEPA questionnaire |
| title |
Validation of a simple screening tool for early diagnosis of advanced Parkinson's disease in daily practice: the CDEPA questionnaire |
| spellingShingle |
Validation of a simple screening tool for early diagnosis of advanced Parkinson's disease in daily practice: the CDEPA questionnaire Martinez-Martin, P. (Pablo)|||/items/eaea88d2-7b1b-4d23-aa23-33fa883fae3c Advanced Parkinson-™s disease (APD) Hoehn and Yahr (HY) scale Neurología |
| title_short |
Validation of a simple screening tool for early diagnosis of advanced Parkinson's disease in daily practice: the CDEPA questionnaire |
| title_full |
Validation of a simple screening tool for early diagnosis of advanced Parkinson's disease in daily practice: the CDEPA questionnaire |
| title_fullStr |
Validation of a simple screening tool for early diagnosis of advanced Parkinson's disease in daily practice: the CDEPA questionnaire |
| title_full_unstemmed |
Validation of a simple screening tool for early diagnosis of advanced Parkinson's disease in daily practice: the CDEPA questionnaire |
| title_sort |
Validation of a simple screening tool for early diagnosis of advanced Parkinson's disease in daily practice: the CDEPA questionnaire |
| dc.creator.none.fl_str_mv |
Martinez-Martin, P. (Pablo)|||/items/eaea88d2-7b1b-4d23-aa23-33fa883fae3c Kulisevsky, J. (Jaime)|||/items/b2ecf863-734d-4e63-9198-4be17e3a25b3 Mir, P. (Pablo)|||/items/46c80c86-091d-4e75-bad9-ad94c5f65840 Tolosa, E. (Eduardo)|||/items/9a0e81d1-14a4-46b3-86d8-b071e8306d2f García-Delgado, P. (Pilar)|||/items/93524a2e-b067-4629-aa3a-5d31f86d1774 Luquin-Piudo, M.R. (María Rosario)|||/items/6449c359-8b33-4ca4-9ff1-ca1505be7ed3 |
| author |
Martinez-Martin, P. (Pablo)|||/items/eaea88d2-7b1b-4d23-aa23-33fa883fae3c |
| author_facet |
Martinez-Martin, P. (Pablo)|||/items/eaea88d2-7b1b-4d23-aa23-33fa883fae3c Kulisevsky, J. (Jaime)|||/items/b2ecf863-734d-4e63-9198-4be17e3a25b3 Mir, P. (Pablo)|||/items/46c80c86-091d-4e75-bad9-ad94c5f65840 Tolosa, E. (Eduardo)|||/items/9a0e81d1-14a4-46b3-86d8-b071e8306d2f García-Delgado, P. (Pilar)|||/items/93524a2e-b067-4629-aa3a-5d31f86d1774 Luquin-Piudo, M.R. (María Rosario)|||/items/6449c359-8b33-4ca4-9ff1-ca1505be7ed3 |
| author_role |
author |
| author2 |
Kulisevsky, J. (Jaime)|||/items/b2ecf863-734d-4e63-9198-4be17e3a25b3 Mir, P. (Pablo)|||/items/46c80c86-091d-4e75-bad9-ad94c5f65840 Tolosa, E. (Eduardo)|||/items/9a0e81d1-14a4-46b3-86d8-b071e8306d2f García-Delgado, P. (Pilar)|||/items/93524a2e-b067-4629-aa3a-5d31f86d1774 Luquin-Piudo, M.R. (María Rosario)|||/items/6449c359-8b33-4ca4-9ff1-ca1505be7ed3 |
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author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Advanced Parkinson-™s disease (APD) Hoehn and Yahr (HY) scale Neurología |
| topic |
Advanced Parkinson-™s disease (APD) Hoehn and Yahr (HY) scale Neurología |
| description |
Early clinical diagnosis of advanced Parkinson’s disease (APD) may be difficult. This study aimed to validate a simple screening tool, the CDEPA questionnaire (“Cuestionario De Enfermedad de Parkinson Avanzada” [Questionnaire for Advanced Parkinson’s Disease]), for the identification of APD in daily practice. The study included 173 consecutively selected patients with PD (40% were women, mean age was 68.4 ± 10.5 years), stratified according to the Hoehn and Yahr (HY) scale. The CDEPA questionnaire defined APD as the presence of severe disability requiring help for activities of daily living (ADL), motor fluctuations with limitation or inability to perform ADL, severe dysphagia, recurrent falls, or dementia. The diagnostic performance of the questionnaire was assessed against the gold standard criterion based on clinical judgment. PD was categorized as advanced in 65 (38%) patients when using the gold standard and in 109 (63%) patients when the CDEPA questionnaire was used. The CDEPA questionnaire and the gold standard agreed moderately (kappa statistic of 0.48, P < 0.001). The CDEPA classified APD with a sensitivity of 97%; specificity of 57%; total accuracy of 72.3%; and area under the curve (for a binary classifier) of 77.2%. Significant differences were found between the groups created by the CDEPA in several usual PD evaluations (HY Scale, SCOPA Motor Scale, Non-motor Symptoms Scale for PD, Clinical Impression of Severity Index for PD, Clinical Global Impression–Severity Scale, and Patient Global Impression–Severity Scale). CDEPA showed satisfactory inter-rater agreement (kappa = 0.88) and test–retest concordance (kappa 0.83). In conclusion, the CDEPA questionnaire is a valid, reliable, and useful instrument for easily screening APD. |
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2018 |
| dc.date.none.fl_str_mv |
2018 2018-01-01 2018 2018-01-01 2023 2023-03-09 |
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journal article http://purl.org/coar/resource_type/c_6501 |
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info:eu-repo/semantics/article |
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article |
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https://hdl.handle.net/10171/65649 |
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https://hdl.handle.net/10171/65649 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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Nature Research |
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Nature Research |
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