Microsaccade Activity During Visuospatial Working Memory in Early-Stage Parkinson’s Disease

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. The underlying code for this study is not publicly available in its entirety but may be made available to qualified researchers on reasonable request from the corresponding a...

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Detalhes bibliográficos
Autores: Farber, Katherine, Jiang, Linjing, Michiels, Mario, Obeso, Ignacio, Leung, Hoi-Chung
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/401663
Acesso em linha:http://hdl.handle.net/10261/401663
Access Level:acceso abierto
Palavra-chave:Microsaccades
Region of interest
Attention
Eye tracking
Parkinson’s disease
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spelling Microsaccade Activity During Visuospatial Working Memory in Early-Stage Parkinson’s DiseaseFarber, KatherineJiang, LinjingMichiels, MarioObeso, IgnacioLeung, Hoi-ChungMicrosaccadesRegion of interestAttentionEye trackingParkinson’s diseaseThe datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. The underlying code for this study is not publicly available in its entirety but may be made available to qualified researchers on reasonable request from the corresponding author.Fixational saccadic eye movements (microsaccades) have been associated with cognitive processes, especially in tasks requiring spatial attention and memory. Alterations in oculomotor and cognitive control are commonly observed in Parkinson’s disease (PD), though it is unclear to what extent microsaccade activity is affected. We acquired eye movement data from sixteen participants with early-stage PD and thirteen older healthy controls to examine the effects of dopamine modulation on microsaccade activity during the delay period of a spatial working memory task. Some microsaccade characteristics, like amplitude and duration, were moderately larger in the PD participants when they were “on” their dopaminergic medication than healthy controls, or when they were “off” medication, while PD participants exhibited microsaccades with a linear amplitude–velocity relationship comparable to controls. Both groups showed similar microsaccade rate patterns across task events, with most participants showing a horizontal bias in microsaccade direction during the delay period regardless of the remembered target location. Overall, our data suggest minimal involvement of microsaccades during visuospatial working memory maintenance under conditions without explicit attentional cues in both subject groups. However, moderate effects of PD-related dopamine deficiency were observed for microsaccade size during working memory maintenance.The present research was supported by the Research Foundation of SUNY and State University of New York at Stony Brook. The funder played no role in the study design, data collection, analysis and interpretation of data, or the writing of this manuscript.Peer reviewedMultidisciplinary Digital Publishing InstituteResearch Foundation for The State University of New YorkState University of New YorkFarber, Katherine [0009-0009-0775-1935]Jiang, Linjing [0009-0001-6344-7841]Michiels, Mario [0000-0002-8738-1517]Obeso, Ignacio [0000-0001-8783-7281]Leung, Hoi-Chung [0000-0001-9549-8793]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2025202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/401663reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/jemr18050046https://doi.org/10.3390/jemr18050046Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4016632026-05-22T06:33:51Z
dc.title.none.fl_str_mv Microsaccade Activity During Visuospatial Working Memory in Early-Stage Parkinson’s Disease
title Microsaccade Activity During Visuospatial Working Memory in Early-Stage Parkinson’s Disease
spellingShingle Microsaccade Activity During Visuospatial Working Memory in Early-Stage Parkinson’s Disease
Farber, Katherine
Microsaccades
Region of interest
Attention
Eye tracking
Parkinson’s disease
title_short Microsaccade Activity During Visuospatial Working Memory in Early-Stage Parkinson’s Disease
title_full Microsaccade Activity During Visuospatial Working Memory in Early-Stage Parkinson’s Disease
title_fullStr Microsaccade Activity During Visuospatial Working Memory in Early-Stage Parkinson’s Disease
title_full_unstemmed Microsaccade Activity During Visuospatial Working Memory in Early-Stage Parkinson’s Disease
title_sort Microsaccade Activity During Visuospatial Working Memory in Early-Stage Parkinson’s Disease
dc.creator.none.fl_str_mv Farber, Katherine
Jiang, Linjing
Michiels, Mario
Obeso, Ignacio
Leung, Hoi-Chung
author Farber, Katherine
author_facet Farber, Katherine
Jiang, Linjing
Michiels, Mario
Obeso, Ignacio
Leung, Hoi-Chung
author_role author
author2 Jiang, Linjing
Michiels, Mario
Obeso, Ignacio
Leung, Hoi-Chung
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Research Foundation for The State University of New York
State University of New York
Farber, Katherine [0009-0009-0775-1935]
Jiang, Linjing [0009-0001-6344-7841]
Michiels, Mario [0000-0002-8738-1517]
Obeso, Ignacio [0000-0001-8783-7281]
Leung, Hoi-Chung [0000-0001-9549-8793]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Microsaccades
Region of interest
Attention
Eye tracking
Parkinson’s disease
topic Microsaccades
Region of interest
Attention
Eye tracking
Parkinson’s disease
description The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. The underlying code for this study is not publicly available in its entirety but may be made available to qualified researchers on reasonable request from the corresponding author.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/401663
url http://hdl.handle.net/10261/401663
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/jemr18050046
https://doi.org/10.3390/jemr18050046
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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