Sex differences in neurocognitive response to metacognitive training in first-episode psychosis: Implications for personalized interventions
PurposeNeurocognitive impairments are a core feature of psychosis and impact long-term outcomes. While sex differences in neurocognition have been observed in first-episode psychosis (FEP), findings remain mixed, and little is known about differential responses to metacognitive interventions. This s...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2026 |
| País: | España |
| Institución: | INCLIVA |
| Repositorio: | r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
| OAI Identifier: | oai:dnet:incliva_____::b3d1b02bc80169dcd38924d2f5f9568f |
| Acceso en línea: | https://incliva.portalinvestigacion.com/publicaciones/20879 |
| Access Level: | acceso abierto |
| Palabra clave: | Psychosis Cognition Psychological Interventions Gender Intersectionality |
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Sex differences in neurocognitive response to metacognitive training in first-episode psychosis: Implications for personalized interventionsVerdaguer-Rodríguez, MComas, JOLópez-Carrilero, RDíaz-Cutraro, LEspinosa, VRuiz-Delgado, IBarrigón, MLGrasa, EPousa, EGonzález-Higueras, FCid, JLorente-Rovira, EBarajas, AAcevedo, AAlonso-Solís, AAnglès, JAnsó, LArgany, MAAznar, ABarrigón, MLBeltrán, MBirulés, IBogas, JLCamprubí, NCarbonero, MCarrasco, ECasañas, RCid, JConesa, ECorripio, ICortes, PDe Apraiz, ADelgado, MDomínguez, LEscartí, MJEscudero, APinos, IEFranco, CGarcía, CGonzalez-Casares, RGonzález-Higueras, FGonzález-Montoro, MALGonzález, EGrasa-Bello, EGuasp, AHuerta-Ramos, MEHuertas, PJiménez-Díaz, ALalucat, LLLlacer, BLópez-Carrilero, RLópez-Frutos, ALorente, ELuengo, AMantecón, NMas-Expósito, LMontes, MMoritz, SMurgui, ENuñez, MPalomer, EPeláez, TPlanell, KPlanellas, CPleguezuelo-Garrote, PPousa, ERenovell, MRodríguez, NRubio, RRuiz-Delgado, ISan Emeterio, MSánchez, ESánchez-Alonso, SSanjuán, JSans, BSió, HTeixidó, MTorres, PVidiella, MVila, MAVila-Badia, RVillegas, FOchoa, SPsychosisCognitionPsychological InterventionsGenderIntersectionalityPurposeNeurocognitive impairments are a core feature of psychosis and impact long-term outcomes. While sex differences in neurocognition have been observed in first-episode psychosis (FEP), findings remain mixed, and little is known about differential responses to metacognitive interventions. This study examined sex differences in the effectiveness of Metacognitive Training (MCT) on neurocognitive outcomes in FEP.MethodsA total of 122 individuals with FEP were randomized to receive either MCT or psychoeducational intervention. Neurocognitive performance was assessed at baseline and at 6-month follow-up using a comprehensive battery (CPT-II, TMT, WCST, Stroop test, TAVEC, WAIS-III Digit Span). General Linear Models tested the effects of intervention, sex, and their interaction, both unadjusted and adjusted for covariates.ResultsMCT led to greater improvements than psychoeducation in immediate recall, processing speed, cognitive flexibility, inhibitory control, and attention. Improvements in immediate recall and Stroop Interference remained significant after adjustment, with Stroop performance also influenced by diagnosis. Across groups, men performed better in verbal memory, while women showed increased serial clustering in short-term recall, an effect that remained significant after adjustment. Notably, a group-by-sex interaction indicated that women receiving MCT experienced greater gains in short-term recall after controlling for covariates.ConclusionsMCT enhances specific neurocognitive functions in FEP and shows promising effects for women in verbal memory processes. These findings underscore the importance of incorporating sex and diagnostic factors when tailoring early interventions for psychosis and highlight the potential of MCT as a personalized cognitive strategy.SPRINGER WIEN2026info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/20879Archives of Womens Mental HealthISSN: 14341816ISSNe: 14351102reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:dnet:incliva_____::b3d1b02bc80169dcd38924d2f5f9568f2026-06-07T16:35:31Z |
| dc.title.none.fl_str_mv |
Sex differences in neurocognitive response to metacognitive training in first-episode psychosis: Implications for personalized interventions |
| title |
Sex differences in neurocognitive response to metacognitive training in first-episode psychosis: Implications for personalized interventions |
| spellingShingle |
Sex differences in neurocognitive response to metacognitive training in first-episode psychosis: Implications for personalized interventions Verdaguer-Rodríguez, M Psychosis Cognition Psychological Interventions Gender Intersectionality |
| title_short |
Sex differences in neurocognitive response to metacognitive training in first-episode psychosis: Implications for personalized interventions |
| title_full |
Sex differences in neurocognitive response to metacognitive training in first-episode psychosis: Implications for personalized interventions |
| title_fullStr |
Sex differences in neurocognitive response to metacognitive training in first-episode psychosis: Implications for personalized interventions |
| title_full_unstemmed |
Sex differences in neurocognitive response to metacognitive training in first-episode psychosis: Implications for personalized interventions |
| title_sort |
Sex differences in neurocognitive response to metacognitive training in first-episode psychosis: Implications for personalized interventions |
| dc.creator.none.fl_str_mv |
Verdaguer-Rodríguez, M Comas, JO López-Carrilero, R Díaz-Cutraro, L Espinosa, V Ruiz-Delgado, I Barrigón, ML Grasa, E Pousa, E González-Higueras, F Cid, J Lorente-Rovira, E Barajas, A Acevedo, A Alonso-Solís, A Anglès, J Ansó, L Argany, MA Aznar, A Barrigón, ML Beltrán, M Birulés, I Bogas, JL Camprubí, N Carbonero, M Carrasco, E Casañas, R Cid, J Conesa, E Corripio, I Cortes, P De Apraiz, A Delgado, M Domínguez, L Escartí, MJ Escudero, A Pinos, IE Franco, C García, C Gonzalez-Casares, R González-Higueras, F González-Montoro, MAL González, E Grasa-Bello, E Guasp, A Huerta-Ramos, ME Huertas, P Jiménez-Díaz, A Lalucat, LL Llacer, B López-Carrilero, R López-Frutos, A Lorente, E Luengo, A Mantecón, N Mas-Expósito, L Montes, M Moritz, S Murgui, E Nuñez, M Palomer, E Peláez, T Planell, K Planellas, C Pleguezuelo-Garrote, P Pousa, E Renovell, M Rodríguez, N Rubio, R Ruiz-Delgado, I San Emeterio, M Sánchez, E Sánchez-Alonso, S Sanjuán, J Sans, B Sió, H Teixidó, M Torres, P Vidiella, M Vila, MA Vila-Badia, R Villegas, F Ochoa, S |
| author |
Verdaguer-Rodríguez, M |
| author_facet |
Verdaguer-Rodríguez, M Comas, JO López-Carrilero, R Díaz-Cutraro, L Espinosa, V Ruiz-Delgado, I Barrigón, ML Grasa, E Pousa, E González-Higueras, F Cid, J Lorente-Rovira, E Barajas, A Acevedo, A Alonso-Solís, A Anglès, J Ansó, L Argany, MA Aznar, A Beltrán, M Birulés, I Bogas, JL Camprubí, N Carbonero, M Carrasco, E Casañas, R Conesa, E Corripio, I Cortes, P De Apraiz, A Delgado, M Domínguez, L Escartí, MJ Escudero, A Pinos, IE Franco, C García, C Gonzalez-Casares, R González-Montoro, MAL González, E Grasa-Bello, E Guasp, A Huerta-Ramos, ME Huertas, P Jiménez-Díaz, A Lalucat, LL Llacer, B López-Frutos, A Lorente, E Luengo, A Mantecón, N Mas-Expósito, L Montes, M Moritz, S Murgui, E Nuñez, M Palomer, E Peláez, T Planell, K Planellas, C Pleguezuelo-Garrote, P Renovell, M Rodríguez, N Rubio, R San Emeterio, M Sánchez, E Sánchez-Alonso, S Sanjuán, J Sans, B Sió, H Teixidó, M Torres, P Vidiella, M Vila, MA Vila-Badia, R Villegas, F Ochoa, S |
| author_role |
author |
| author2 |
Comas, JO López-Carrilero, R Díaz-Cutraro, L Espinosa, V Ruiz-Delgado, I Barrigón, ML Grasa, E Pousa, E González-Higueras, F Cid, J Lorente-Rovira, E Barajas, A Acevedo, A Alonso-Solís, A Anglès, J Ansó, L Argany, MA Aznar, A Beltrán, M Birulés, I Bogas, JL Camprubí, N Carbonero, M Carrasco, E Casañas, R Conesa, E Corripio, I Cortes, P De Apraiz, A Delgado, M Domínguez, L Escartí, MJ Escudero, A Pinos, IE Franco, C García, C Gonzalez-Casares, R González-Montoro, MAL González, E Grasa-Bello, E Guasp, A Huerta-Ramos, ME Huertas, P Jiménez-Díaz, A Lalucat, LL Llacer, B López-Frutos, A Lorente, E Luengo, A Mantecón, N Mas-Expósito, L Montes, M Moritz, S Murgui, E Nuñez, M Palomer, E Peláez, T Planell, K Planellas, C Pleguezuelo-Garrote, P Renovell, M Rodríguez, N Rubio, R San Emeterio, M Sánchez, E Sánchez-Alonso, S Sanjuán, J Sans, B Sió, H Teixidó, M Torres, P Vidiella, M Vila, MA Vila-Badia, R Villegas, F Ochoa, S |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Psychosis Cognition Psychological Interventions Gender Intersectionality |
| topic |
Psychosis Cognition Psychological Interventions Gender Intersectionality |
| description |
PurposeNeurocognitive impairments are a core feature of psychosis and impact long-term outcomes. While sex differences in neurocognition have been observed in first-episode psychosis (FEP), findings remain mixed, and little is known about differential responses to metacognitive interventions. This study examined sex differences in the effectiveness of Metacognitive Training (MCT) on neurocognitive outcomes in FEP.MethodsA total of 122 individuals with FEP were randomized to receive either MCT or psychoeducational intervention. Neurocognitive performance was assessed at baseline and at 6-month follow-up using a comprehensive battery (CPT-II, TMT, WCST, Stroop test, TAVEC, WAIS-III Digit Span). General Linear Models tested the effects of intervention, sex, and their interaction, both unadjusted and adjusted for covariates.ResultsMCT led to greater improvements than psychoeducation in immediate recall, processing speed, cognitive flexibility, inhibitory control, and attention. Improvements in immediate recall and Stroop Interference remained significant after adjustment, with Stroop performance also influenced by diagnosis. Across groups, men performed better in verbal memory, while women showed increased serial clustering in short-term recall, an effect that remained significant after adjustment. Notably, a group-by-sex interaction indicated that women receiving MCT experienced greater gains in short-term recall after controlling for covariates.ConclusionsMCT enhances specific neurocognitive functions in FEP and shows promising effects for women in verbal memory processes. These findings underscore the importance of incorporating sex and diagnostic factors when tailoring early interventions for psychosis and highlight the potential of MCT as a personalized cognitive strategy. |
| publishDate |
2026 |
| dc.date.none.fl_str_mv |
2026 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://incliva.portalinvestigacion.com/publicaciones/20879 |
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https://incliva.portalinvestigacion.com/publicaciones/20879 |
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Inglés |
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Inglés |
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info:eu-repo/semantics/openAccess |
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openAccess |
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SPRINGER WIEN |
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SPRINGER WIEN |
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Archives of Womens Mental Health ISSN: 14341816 ISSNe: 14351102 reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname:INCLIVA |
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INCLIVA |
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r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA |
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