Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis
Objective To assess organ damage, with emphasis on the cardiovascular system, over the different stages of the disease in a large SLE cohort.Methods Multicentre, longitudinal study of a cohort of 4219 patients with SLE enrolled in the Spanish Society of Rheumatology Lupus Registry. Organ damage was...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/215745 |
| Acceso en línea: | https://hdl.handle.net/2445/215745 |
| Access Level: | acceso abierto |
| Palabra clave: | Lupus eritematós Sistema cardiovascular Lupus erythematosus Cardiovascular system |
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oai:diposit.ub.edu:2445/215745 |
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España |
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Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysisAltabás González, IreneRua-Figueroa, IñigoMouriño, CoralRoberts, KarenJimenez, NormanMartinez Barrio, JuliaGalindo, MaríaCalvo Alén, JaimeDel Campo Pérez, VictorUriarte Itzazelaia, EstherTomero, EvaFreire González, MercedesMartínez Taboada, VíctorSalgado Pérez, EvaVela, PalomaFernandez Nebro, AntonioOlivé, AlejandroNarváez, JavierMenor Almagro, RaúlSoler, Gregorio SantosHernández Beriain, José ÁngelManero, JavierAurrecoechea, ElenaIbarguengoitia Barrena, OihaneMontilla, CarlosBonilla, GemaTorrente Segarra, VicençCacheda, Ana PaulaGarcía Villanueva, María JesúsMoriano Morales, ClaudiaManteca, Concepción FitoLozano Rivas, NuriaBohórquez, CristinaPego Reigosa, José MaríaLupus eritematósSistema cardiovascularLupus erythematosusCardiovascular systemObjective To assess organ damage, with emphasis on the cardiovascular system, over the different stages of the disease in a large SLE cohort.Methods Multicentre, longitudinal study of a cohort of 4219 patients with SLE enrolled in the Spanish Society of Rheumatology Lupus Registry. Organ damage was ascertained using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). We longitudinally analysed SDI (globally and for each domain) over time only in the 1274 patients whose dates of damage events had been recorded.Results During the first year after diagnosis of SLE, 20% of the 1274 patients presented with new damage manifestations. At years 2 and 3, new damage was recorded in 11% and 9% of patients. The annual percentage of patients with new damage after year 5 decreased to 5%. In the first year with the disease, most damage was accumulated in the musculoskeletal, neuropsychiatric and renal systems; in later stages, most damage was in the musculoskeletal, ocular and cardiovascular systems. Considering 'cerebrovascular accident' and 'claudication for 6 months' as cardiovascular items, the cardiovascular system was the second most affected system during the early stages of SLE, with 19% of the patients who presented with damage affected at first year after diagnosis. During the late stages, 20-25% of the patients presenting with new damage did so in this modified cardiovascular domain of the SDI.Conclusions New damage occurs mainly during the first year following diagnosis of SLE. Cardiovascular damage is relevant in both the early and the late stages of the disease. Strategies to prevent cardiovascular damage should be implemented early after diagnosis of SLE.BMJ2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/215745Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1136/lupus-2023-001064Lupus Science & Medicine, 2024, vol. 11, num. 2, p. e001064https://doi.org/10.1136/lupus-2023-001064cc by (c) Altabás González, Irene et al., 2024http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2157452026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis |
| title |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis |
| spellingShingle |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis Altabás González, Irene Lupus eritematós Sistema cardiovascular Lupus erythematosus Cardiovascular system |
| title_short |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis |
| title_full |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis |
| title_fullStr |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis |
| title_full_unstemmed |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis |
| title_sort |
Damage in a large systemic lupus erythematosus cohort from the Spanish Society of Rheumatology Lupus Registry (RELESSER) with emphasis on the cardiovascular system: a longitudinal analysis |
| dc.creator.none.fl_str_mv |
Altabás González, Irene Rua-Figueroa, Iñigo Mouriño, Coral Roberts, Karen Jimenez, Norman Martinez Barrio, Julia Galindo, María Calvo Alén, Jaime Del Campo Pérez, Victor Uriarte Itzazelaia, Esther Tomero, Eva Freire González, Mercedes Martínez Taboada, Víctor Salgado Pérez, Eva Vela, Paloma Fernandez Nebro, Antonio Olivé, Alejandro Narváez, Javier Menor Almagro, Raúl Soler, Gregorio Santos Hernández Beriain, José Ángel Manero, Javier Aurrecoechea, Elena Ibarguengoitia Barrena, Oihane Montilla, Carlos Bonilla, Gema Torrente Segarra, Vicenç Cacheda, Ana Paula García Villanueva, María Jesús Moriano Morales, Claudia Manteca, Concepción Fito Lozano Rivas, Nuria Bohórquez, Cristina Pego Reigosa, José María |
| author |
Altabás González, Irene |
| author_facet |
Altabás González, Irene Rua-Figueroa, Iñigo Mouriño, Coral Roberts, Karen Jimenez, Norman Martinez Barrio, Julia Galindo, María Calvo Alén, Jaime Del Campo Pérez, Victor Uriarte Itzazelaia, Esther Tomero, Eva Freire González, Mercedes Martínez Taboada, Víctor Salgado Pérez, Eva Vela, Paloma Fernandez Nebro, Antonio Olivé, Alejandro Narváez, Javier Menor Almagro, Raúl Soler, Gregorio Santos Hernández Beriain, José Ángel Manero, Javier Aurrecoechea, Elena Ibarguengoitia Barrena, Oihane Montilla, Carlos Bonilla, Gema Torrente Segarra, Vicenç Cacheda, Ana Paula García Villanueva, María Jesús Moriano Morales, Claudia Manteca, Concepción Fito Lozano Rivas, Nuria Bohórquez, Cristina Pego Reigosa, José María |
| author_role |
author |
| author2 |
Rua-Figueroa, Iñigo Mouriño, Coral Roberts, Karen Jimenez, Norman Martinez Barrio, Julia Galindo, María Calvo Alén, Jaime Del Campo Pérez, Victor Uriarte Itzazelaia, Esther Tomero, Eva Freire González, Mercedes Martínez Taboada, Víctor Salgado Pérez, Eva Vela, Paloma Fernandez Nebro, Antonio Olivé, Alejandro Narváez, Javier Menor Almagro, Raúl Soler, Gregorio Santos Hernández Beriain, José Ángel Manero, Javier Aurrecoechea, Elena Ibarguengoitia Barrena, Oihane Montilla, Carlos Bonilla, Gema Torrente Segarra, Vicenç Cacheda, Ana Paula García Villanueva, María Jesús Moriano Morales, Claudia Manteca, Concepción Fito Lozano Rivas, Nuria Bohórquez, Cristina Pego Reigosa, José María |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Lupus eritematós Sistema cardiovascular Lupus erythematosus Cardiovascular system |
| topic |
Lupus eritematós Sistema cardiovascular Lupus erythematosus Cardiovascular system |
| description |
Objective To assess organ damage, with emphasis on the cardiovascular system, over the different stages of the disease in a large SLE cohort.Methods Multicentre, longitudinal study of a cohort of 4219 patients with SLE enrolled in the Spanish Society of Rheumatology Lupus Registry. Organ damage was ascertained using the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI). We longitudinally analysed SDI (globally and for each domain) over time only in the 1274 patients whose dates of damage events had been recorded.Results During the first year after diagnosis of SLE, 20% of the 1274 patients presented with new damage manifestations. At years 2 and 3, new damage was recorded in 11% and 9% of patients. The annual percentage of patients with new damage after year 5 decreased to 5%. In the first year with the disease, most damage was accumulated in the musculoskeletal, neuropsychiatric and renal systems; in later stages, most damage was in the musculoskeletal, ocular and cardiovascular systems. Considering 'cerebrovascular accident' and 'claudication for 6 months' as cardiovascular items, the cardiovascular system was the second most affected system during the early stages of SLE, with 19% of the patients who presented with damage affected at first year after diagnosis. During the late stages, 20-25% of the patients presenting with new damage did so in this modified cardiovascular domain of the SDI.Conclusions New damage occurs mainly during the first year following diagnosis of SLE. Cardiovascular damage is relevant in both the early and the late stages of the disease. Strategies to prevent cardiovascular damage should be implemented early after diagnosis of SLE. |
| publishDate |
2024 |
| dc.date.none.fl_str_mv |
2024 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/215745 |
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https://hdl.handle.net/2445/215745 |
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Inglés |
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Inglés |
| dc.relation.none.fl_str_mv |
Reproducció del document publicat a: https://doi.org/10.1136/lupus-2023-001064 Lupus Science & Medicine, 2024, vol. 11, num. 2, p. e001064 https://doi.org/10.1136/lupus-2023-001064 |
| dc.rights.none.fl_str_mv |
cc by (c) Altabás González, Irene et al., 2024 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess |
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cc by (c) Altabás González, Irene et al., 2024 http://creativecommons.org/licenses/by/3.0/es/ |
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openAccess |
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application/pdf |
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BMJ |
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BMJ |
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Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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