Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA study

This retrospective analysis of the phase III GOYA study investigated the prognostic value of baseline metabolic tumor volume parameters and maximum standardized uptake values for overall and progression-free survival (PFS) in treatment-naïve diffuse large B-cell lymphoma. Baseline total metabolic tu...

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Autores: Kostakoglu, Lale, Mattiello, Federico, Martelli, Maurizio, Sehn, Laurie H., Belada, David, Carella, Ghiggi, Chiara, Chua, Neil, González Barca, Eva, Hong, Xiaonan, Pinto, Antonio, Shi, Yuankai, Tatsumi, Yoichi, Bolen, Christopher, Knapp, Andrea, Sellam, Gila, Nielsen, Tina, Sahin, Deniz, Vitolo, Umberto, Trneny, Marek
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/188755
Acceso en línea:https://hdl.handle.net/2445/188755
Access Level:acceso abierto
Palabra clave:Limfomes
Glucòlisi
Tomografia per emissió de positrons
Pronòstic mèdic
Lymphomas
Glycolysis
Positron emission tomography
Prognosis
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spelling Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA studyKostakoglu, LaleMattiello, FedericoMartelli, MaurizioSehn, Laurie H.Belada, DavidCarellaGhiggi, ChiaraChua, NeilGonzález Barca, EvaHong, XiaonanPinto, AntonioShi, YuankaiTatsumi, YoichiBolen, ChristopherKnapp, AndreaSellam, GilaNielsen, TinaSahin, DenizVitolo, UmbertoTrneny, MarekLimfomesGlucòlisiTomografia per emissió de positronsPronòstic mèdicLymphomasGlycolysisPositron emission tomographyPrognosisThis retrospective analysis of the phase III GOYA study investigated the prognostic value of baseline metabolic tumor volume parameters and maximum standardized uptake values for overall and progression-free survival (PFS) in treatment-naïve diffuse large B-cell lymphoma. Baseline total metabolic tumor volume (determined for tumors >1 mL using a threshold of 1.5 times the mean liver standardized uptake value +2 standard deviations), total lesion glycolysis, and maximum standardized uptake value positron emission tomography data were dichotomized based on receiver operating characteristic analysis and divided into quartiles by baseline population distribution. Of 1,418 enrolled patients, 1,305 had a baseline positron emission tomography scan with detectable lesions. Optimal cut-offs were 366 cm3 for total metabolic tumor volume and 3,004 g for total lesion glycolysis. High total metabolic tumor volume and total lesion glycolysis predicted poorer PFS, with associations retained after adjustment for baseline and disease characteristics (high total metabolic tumor volume hazard ratio: 1.71, 95% confidence interval [CI]: 1.352.18; total lesion glycolysis hazard ratio: 1.46; 95% CI: 1.15-1.86). Total metabolic tumor volume was prognostic for PFS in subgroups with International Prognostic Index scores 0-2 and 3-5, and those with different cell-of-origin subtypes. Maximum standardized uptake value had no prognostic value in this setting. High total metabolic tumor volume associated with high International Prognostic Index or non-germinal center B-cell classification identified the highest-risk cohort for unfavorable prognosis. In conclusion, baseline total metabolic tumor volume and total lesion glycolysis are independent predictors of PFS in patients with diffuse large B-cell lymphoma after first-line immunochemotherapy.Ferrata Storti Foundation2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/188755Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.3324/haematol.2021.278663Haematologica, 2021, vol. 107, num. 7, p. 1633-1642https://doi.org/10.3324/haematol.2021.278663(c) Ferrata Storti Foundation, 2021info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1887552026-05-27T06:46:51Z
dc.title.none.fl_str_mv Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA study
title Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA study
spellingShingle Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA study
Kostakoglu, Lale
Limfomes
Glucòlisi
Tomografia per emissió de positrons
Pronòstic mèdic
Lymphomas
Glycolysis
Positron emission tomography
Prognosis
title_short Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA study
title_full Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA study
title_fullStr Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA study
title_full_unstemmed Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA study
title_sort Total metabolic tumor volume as a survival predictor for patients with diffuse large B-cell lymphoma in the GOYA study
dc.creator.none.fl_str_mv Kostakoglu, Lale
Mattiello, Federico
Martelli, Maurizio
Sehn, Laurie H.
Belada, David
Carella
Ghiggi, Chiara
Chua, Neil
González Barca, Eva
Hong, Xiaonan
Pinto, Antonio
Shi, Yuankai
Tatsumi, Yoichi
Bolen, Christopher
Knapp, Andrea
Sellam, Gila
Nielsen, Tina
Sahin, Deniz
Vitolo, Umberto
Trneny, Marek
author Kostakoglu, Lale
author_facet Kostakoglu, Lale
Mattiello, Federico
Martelli, Maurizio
Sehn, Laurie H.
Belada, David
Carella
Ghiggi, Chiara
Chua, Neil
González Barca, Eva
Hong, Xiaonan
Pinto, Antonio
Shi, Yuankai
Tatsumi, Yoichi
Bolen, Christopher
Knapp, Andrea
Sellam, Gila
Nielsen, Tina
Sahin, Deniz
Vitolo, Umberto
Trneny, Marek
author_role author
author2 Mattiello, Federico
Martelli, Maurizio
Sehn, Laurie H.
Belada, David
Carella
Ghiggi, Chiara
Chua, Neil
González Barca, Eva
Hong, Xiaonan
Pinto, Antonio
Shi, Yuankai
Tatsumi, Yoichi
Bolen, Christopher
Knapp, Andrea
Sellam, Gila
Nielsen, Tina
Sahin, Deniz
Vitolo, Umberto
Trneny, Marek
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Limfomes
Glucòlisi
Tomografia per emissió de positrons
Pronòstic mèdic
Lymphomas
Glycolysis
Positron emission tomography
Prognosis
topic Limfomes
Glucòlisi
Tomografia per emissió de positrons
Pronòstic mèdic
Lymphomas
Glycolysis
Positron emission tomography
Prognosis
description This retrospective analysis of the phase III GOYA study investigated the prognostic value of baseline metabolic tumor volume parameters and maximum standardized uptake values for overall and progression-free survival (PFS) in treatment-naïve diffuse large B-cell lymphoma. Baseline total metabolic tumor volume (determined for tumors >1 mL using a threshold of 1.5 times the mean liver standardized uptake value +2 standard deviations), total lesion glycolysis, and maximum standardized uptake value positron emission tomography data were dichotomized based on receiver operating characteristic analysis and divided into quartiles by baseline population distribution. Of 1,418 enrolled patients, 1,305 had a baseline positron emission tomography scan with detectable lesions. Optimal cut-offs were 366 cm3 for total metabolic tumor volume and 3,004 g for total lesion glycolysis. High total metabolic tumor volume and total lesion glycolysis predicted poorer PFS, with associations retained after adjustment for baseline and disease characteristics (high total metabolic tumor volume hazard ratio: 1.71, 95% confidence interval [CI]: 1.352.18; total lesion glycolysis hazard ratio: 1.46; 95% CI: 1.15-1.86). Total metabolic tumor volume was prognostic for PFS in subgroups with International Prognostic Index scores 0-2 and 3-5, and those with different cell-of-origin subtypes. Maximum standardized uptake value had no prognostic value in this setting. High total metabolic tumor volume associated with high International Prognostic Index or non-germinal center B-cell classification identified the highest-risk cohort for unfavorable prognosis. In conclusion, baseline total metabolic tumor volume and total lesion glycolysis are independent predictors of PFS in patients with diffuse large B-cell lymphoma after first-line immunochemotherapy.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/188755
url https://hdl.handle.net/2445/188755
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3324/haematol.2021.278663
Haematologica, 2021, vol. 107, num. 7, p. 1633-1642
https://doi.org/10.3324/haematol.2021.278663
dc.rights.none.fl_str_mv (c) Ferrata Storti Foundation, 2021
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Ferrata Storti Foundation, 2021
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Ferrata Storti Foundation
publisher.none.fl_str_mv Ferrata Storti Foundation
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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