An Experimental Model of Neuro–Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells

The cornea is an avascular connective tissue that is crucial, not only as the primary barrier of the eye but also as a proper transparent refractive structure. Corneal transparency is necessary for vision and is the result of several factors, including its highly organized structure, the physiology...

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Detalles Bibliográficos
Autores: Frutos-Rincón, Laura, Gómez Sánchez, José Antonio, Íñigo-Portugués, Almudena, Acosta, M. Carmen, Gallar, Juana
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Miguel Hernández de Elche
Repositorio:REDIUMH. Depósito Digital de la UMH
OAI Identifier:oai:dspace.umh.es:11000/38115
Acceso en línea:https://hdl.handle.net/11000/38115
Access Level:acceso abierto
Palabra clave:corneal nerves
dendritic cells
neuro‐immune interactions
ocular inflammation
ocular pain
animal models
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spelling An Experimental Model of Neuro–Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic CellsFrutos-Rincón, LauraGómez Sánchez, José AntonioÍñigo-Portugués, AlmudenaAcosta, M. CarmenGallar, Juanacorneal nervesdendritic cellsneuro‐immune interactionsocular inflammationocular painanimal modelsThe cornea is an avascular connective tissue that is crucial, not only as the primary barrier of the eye but also as a proper transparent refractive structure. Corneal transparency is necessary for vision and is the result of several factors, including its highly organized structure, the physiology of its few cellular components, the lack of myelinated nerves (although it is extremely innervated), the tightly controlled hydration state, and the absence of blood and lymphatic vessels in healthy conditions, among others. The avascular, immune‐privileged tissue of the cornea is an ideal model to study the interactions between its well‐characterized and dense sensory nerves (easily accessible for both focal electrophysiological recording and morphological studies) and the low number of resident immune cell types, distinguished from those cells migrating from blood vessels. This paper presents an overview of the corneal structure and innervation, the resident dendritic cell (DC) subpopulations present in the cornea, their distribution in relation to corneal nerves, and their role in ocular inflammatory diseases. A mouse model in which sensory axons are constitutively labeled with tdTomato and DCs with green fluorescent protein (GFP) allows further analysis of the neuroimmune crosstalk under inflammatory and steady‐state conditions of the eye.MDPIDepartamentos de la UMH::FisiologíaInstitutos de la UMH::Instituto de Neurociencias202520252022info:eu-repo/semantics/articleapplication/pdf27application/pdfhttps://hdl.handle.net/11000/38115reponame:REDIUMH. Depósito Digital de la UMHinstname:Universidad Miguel Hernández de ElcheInglés10.3390/ijms23062997info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:dspace.umh.es:11000/381152026-05-27T13:36:21Z
dc.title.none.fl_str_mv An Experimental Model of Neuro–Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells
title An Experimental Model of Neuro–Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells
spellingShingle An Experimental Model of Neuro–Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells
Frutos-Rincón, Laura
corneal nerves
dendritic cells
neuro‐immune interactions
ocular inflammation
ocular pain
animal models
title_short An Experimental Model of Neuro–Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells
title_full An Experimental Model of Neuro–Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells
title_fullStr An Experimental Model of Neuro–Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells
title_full_unstemmed An Experimental Model of Neuro–Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells
title_sort An Experimental Model of Neuro–Immune Interactions in the Eye: Corneal Sensory Nerves and Resident Dendritic Cells
dc.creator.none.fl_str_mv Frutos-Rincón, Laura
Gómez Sánchez, José Antonio
Íñigo-Portugués, Almudena
Acosta, M. Carmen
Gallar, Juana
author Frutos-Rincón, Laura
author_facet Frutos-Rincón, Laura
Gómez Sánchez, José Antonio
Íñigo-Portugués, Almudena
Acosta, M. Carmen
Gallar, Juana
author_role author
author2 Gómez Sánchez, José Antonio
Íñigo-Portugués, Almudena
Acosta, M. Carmen
Gallar, Juana
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Departamentos de la UMH::Fisiología
Institutos de la UMH::Instituto de Neurociencias
dc.subject.none.fl_str_mv corneal nerves
dendritic cells
neuro‐immune interactions
ocular inflammation
ocular pain
animal models
topic corneal nerves
dendritic cells
neuro‐immune interactions
ocular inflammation
ocular pain
animal models
description The cornea is an avascular connective tissue that is crucial, not only as the primary barrier of the eye but also as a proper transparent refractive structure. Corneal transparency is necessary for vision and is the result of several factors, including its highly organized structure, the physiology of its few cellular components, the lack of myelinated nerves (although it is extremely innervated), the tightly controlled hydration state, and the absence of blood and lymphatic vessels in healthy conditions, among others. The avascular, immune‐privileged tissue of the cornea is an ideal model to study the interactions between its well‐characterized and dense sensory nerves (easily accessible for both focal electrophysiological recording and morphological studies) and the low number of resident immune cell types, distinguished from those cells migrating from blood vessels. This paper presents an overview of the corneal structure and innervation, the resident dendritic cell (DC) subpopulations present in the cornea, their distribution in relation to corneal nerves, and their role in ocular inflammatory diseases. A mouse model in which sensory axons are constitutively labeled with tdTomato and DCs with green fluorescent protein (GFP) allows further analysis of the neuroimmune crosstalk under inflammatory and steady‐state conditions of the eye.
publishDate 2022
dc.date.none.fl_str_mv 2022
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/11000/38115
url https://hdl.handle.net/11000/38115
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv 10.3390/ijms23062997
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
27
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:REDIUMH. Depósito Digital de la UMH
instname:Universidad Miguel Hernández de Elche
instname_str Universidad Miguel Hernández de Elche
reponame_str REDIUMH. Depósito Digital de la UMH
collection REDIUMH. Depósito Digital de la UMH
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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