The Impact of Graft-versus-Host Disease on the Relapse Rate in Patients with Lymphoma Depends on the Histological Subtype and the Intensity of the Conditioning Regimen

The purpose of this study was to analyze the impact of graft-versus-host disease (GVHD) on the relapse rate of different lymphoma subtypes after allogeneic hematopoietic cell transplantation (allo-HCT). Adult patients with a diagnosis of Hodgkin lymphoma, diffuse large B cell lymphoma, follicular ly...

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Autores: Urbano-Ispizua, A, Pavletic, SZ, Flowers, ME, Klein, JP, Zhang, MJ, Carreras, J, Montoto, S, Perales, MA, Aljurf, MD, Akpek, G, Bredeson, CN, Costa, LJ, Dandoy, C, Freytes, CO, Fung, HC, Gale, RP, Gibson, J, Hamadani, M, Hayashi, RJ, Inamoto, Y, Inwards, DJ, Lazarus, HM, Maloney, DG, Martino, R, Munker, R, Nishihori, T, Olsson, RF, Rizzieri, DA, Reshef, R, Saad, A, Savani, BN, Schouten, HC, Smith, SM, Socie, G, Wirk, B, Yu, LC, Saber, W
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2015
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositório:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p8324
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8324
Access Level:Acceso aberto
Palavra-chave:Graft-versus-host disease
Lymphoma
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spelling The Impact of Graft-versus-Host Disease on the Relapse Rate in Patients with Lymphoma Depends on the Histological Subtype and the Intensity of the Conditioning RegimenUrbano-Ispizua, APavletic, SZFlowers, MEKlein, JPZhang, MJCarreras, JMontoto, SPerales, MAAljurf, MDAkpek, GBredeson, CNCosta, LJDandoy, CFreytes, COFung, HCGale, RPGibson, JHamadani, MHayashi, RJInamoto, YInwards, DJLazarus, HMMaloney, DGMartino, RMunker, RNishihori, TOlsson, RFRizzieri, DAReshef, RSaad, ASavani, BNSchouten, HCSmith, SMSocie, GWirk, BYu, LCSaber, WGraft-versus-host diseaseLymphomaThe purpose of this study was to analyze the impact of graft-versus-host disease (GVHD) on the relapse rate of different lymphoma subtypes after allogeneic hematopoietic cell transplantation (allo-HCT). Adult patients with a diagnosis of Hodgkin lymphoma, diffuse large B cell lymphoma, follicular lymphoma (FL), peripheral T cell lymphoma, or mantle cell lymphoma (MCL) undergoing HLA-identical sibling or unrelated donor hematopoietic cell transplantation between 1997 and 2009 were included. Two thousand six hundred eleven cases were included. A reduced-intensity conditioning (RIC) regimen was used in 62.8% of the transplantations. In a multivariate analysis of myeloablative cases (n = 970), neither acute (aGVHD) nor chronic GVHD (cGVHD) were significantly associated with a lower incidence of relapse/progression in any lymphoma subtype. In contrast, the analysis of RIC cases (n = 1641) showed that cGVHD was associated with a lower incidence of relapse/progression in FL (risk ratio [RR],.51; P = 3.049) and in MCL (RR,.41; P = .019). Patients with FL or MCL developing both aGVHD and cGVHD had the lowest risk of relapse (RR,.14; P = .007; and RR,.15; P = .0019, respectively). Of interest, the effect of GVHD on decreasing relapse was similar in patients with sensitive disease and chemoresistant disease. Unfortunately, both aGVHD and cGVHD had a deleterious effect on treatment-related mortality and overall survival (OS) in FL cases but did not affect treatment-related mortality, OS or PFS in MCL. This study reinforces the use of RIC allo-HCT as a platform for immunotherapy in FL and MCL patients. (C) 2015 American Society for Blood and Marrow Transplantation.ELSEVIER SCIENCE INC2015info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8324BIOLOGY OF BLOOD AND MARROW TRANSPLANTATIONISSN: 10838791ISSNe: 15236536reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p83242026-06-14T12:41:47Z
dc.title.none.fl_str_mv The Impact of Graft-versus-Host Disease on the Relapse Rate in Patients with Lymphoma Depends on the Histological Subtype and the Intensity of the Conditioning Regimen
title The Impact of Graft-versus-Host Disease on the Relapse Rate in Patients with Lymphoma Depends on the Histological Subtype and the Intensity of the Conditioning Regimen
spellingShingle The Impact of Graft-versus-Host Disease on the Relapse Rate in Patients with Lymphoma Depends on the Histological Subtype and the Intensity of the Conditioning Regimen
Urbano-Ispizua, A
Graft-versus-host disease
Lymphoma
title_short The Impact of Graft-versus-Host Disease on the Relapse Rate in Patients with Lymphoma Depends on the Histological Subtype and the Intensity of the Conditioning Regimen
title_full The Impact of Graft-versus-Host Disease on the Relapse Rate in Patients with Lymphoma Depends on the Histological Subtype and the Intensity of the Conditioning Regimen
title_fullStr The Impact of Graft-versus-Host Disease on the Relapse Rate in Patients with Lymphoma Depends on the Histological Subtype and the Intensity of the Conditioning Regimen
title_full_unstemmed The Impact of Graft-versus-Host Disease on the Relapse Rate in Patients with Lymphoma Depends on the Histological Subtype and the Intensity of the Conditioning Regimen
title_sort The Impact of Graft-versus-Host Disease on the Relapse Rate in Patients with Lymphoma Depends on the Histological Subtype and the Intensity of the Conditioning Regimen
dc.creator.none.fl_str_mv Urbano-Ispizua, A
Pavletic, SZ
Flowers, ME
Klein, JP
Zhang, MJ
Carreras, J
Montoto, S
Perales, MA
Aljurf, MD
Akpek, G
Bredeson, CN
Costa, LJ
Dandoy, C
Freytes, CO
Fung, HC
Gale, RP
Gibson, J
Hamadani, M
Hayashi, RJ
Inamoto, Y
Inwards, DJ
Lazarus, HM
Maloney, DG
Martino, R
Munker, R
Nishihori, T
Olsson, RF
Rizzieri, DA
Reshef, R
Saad, A
Savani, BN
Schouten, HC
Smith, SM
Socie, G
Wirk, B
Yu, LC
Saber, W
author Urbano-Ispizua, A
author_facet Urbano-Ispizua, A
Pavletic, SZ
Flowers, ME
Klein, JP
Zhang, MJ
Carreras, J
Montoto, S
Perales, MA
Aljurf, MD
Akpek, G
Bredeson, CN
Costa, LJ
Dandoy, C
Freytes, CO
Fung, HC
Gale, RP
Gibson, J
Hamadani, M
Hayashi, RJ
Inamoto, Y
Inwards, DJ
Lazarus, HM
Maloney, DG
Martino, R
Munker, R
Nishihori, T
Olsson, RF
Rizzieri, DA
Reshef, R
Saad, A
Savani, BN
Schouten, HC
Smith, SM
Socie, G
Wirk, B
Yu, LC
Saber, W
author_role author
author2 Pavletic, SZ
Flowers, ME
Klein, JP
Zhang, MJ
Carreras, J
Montoto, S
Perales, MA
Aljurf, MD
Akpek, G
Bredeson, CN
Costa, LJ
Dandoy, C
Freytes, CO
Fung, HC
Gale, RP
Gibson, J
Hamadani, M
Hayashi, RJ
Inamoto, Y
Inwards, DJ
Lazarus, HM
Maloney, DG
Martino, R
Munker, R
Nishihori, T
Olsson, RF
Rizzieri, DA
Reshef, R
Saad, A
Savani, BN
Schouten, HC
Smith, SM
Socie, G
Wirk, B
Yu, LC
Saber, W
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Graft-versus-host disease
Lymphoma
topic Graft-versus-host disease
Lymphoma
description The purpose of this study was to analyze the impact of graft-versus-host disease (GVHD) on the relapse rate of different lymphoma subtypes after allogeneic hematopoietic cell transplantation (allo-HCT). Adult patients with a diagnosis of Hodgkin lymphoma, diffuse large B cell lymphoma, follicular lymphoma (FL), peripheral T cell lymphoma, or mantle cell lymphoma (MCL) undergoing HLA-identical sibling or unrelated donor hematopoietic cell transplantation between 1997 and 2009 were included. Two thousand six hundred eleven cases were included. A reduced-intensity conditioning (RIC) regimen was used in 62.8% of the transplantations. In a multivariate analysis of myeloablative cases (n = 970), neither acute (aGVHD) nor chronic GVHD (cGVHD) were significantly associated with a lower incidence of relapse/progression in any lymphoma subtype. In contrast, the analysis of RIC cases (n = 1641) showed that cGVHD was associated with a lower incidence of relapse/progression in FL (risk ratio [RR],.51; P = 3.049) and in MCL (RR,.41; P = .019). Patients with FL or MCL developing both aGVHD and cGVHD had the lowest risk of relapse (RR,.14; P = .007; and RR,.15; P = .0019, respectively). Of interest, the effect of GVHD on decreasing relapse was similar in patients with sensitive disease and chemoresistant disease. Unfortunately, both aGVHD and cGVHD had a deleterious effect on treatment-related mortality and overall survival (OS) in FL cases but did not affect treatment-related mortality, OS or PFS in MCL. This study reinforces the use of RIC allo-HCT as a platform for immunotherapy in FL and MCL patients. (C) 2015 American Society for Blood and Marrow Transplantation.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8324
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=8324
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCIENCE INC
publisher.none.fl_str_mv ELSEVIER SCIENCE INC
dc.source.none.fl_str_mv BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
ISSN: 10838791
ISSNe: 15236536
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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