Data from: Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms

crisp_dna DNA alignment of the cysteine rich secretory protein (CRISP) toxin family LAAO_dna DNA alignment of the L-amino acid oxidase (LAAO) toxin family lectin_dna DNA alignment of the C-type lectin (CTL) toxin family pla2_dna DNA alignment of the phospholipase A2 (PLA2) toxin family serine_protea...

Descripción completa

Detalles Bibliográficos
Autores: Casewell, Nicholas R., Wagstaff, Simon C., Wüster, Wolfgang, Cook, Darren A. N., Bolton, Fiona M. S., King, Sarah I., Pla, Davinia, Sanz, Libia, Calvete, Juan J., Harrison, Robert A.
Tipo de recurso: conjunto de datos
Fecha de publicación:2015
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/282293
Acceso en línea:http://hdl.handle.net/10261/282293
http://datadryad.org/stash/dataset/doi:10.5061/dryad.1j292
Access Level:acceso abierto
Palabra clave:Cerastes cerastes
Echis pyramidum leakeyi
Venom
Echis carinatus sochureki
Bitis arietans
Echis coloratus
Echis ocellatus
id ES_ca675226cd3596ecf45bce73bbd7f002
oai_identifier_str oai:digital.csic.es:10261/282293
network_acronym_str ES
network_name_str España
repository_id_str
spelling Data from: Medically important differences in snake venom composition are dictated by distinct postgenomic mechanismsCasewell, Nicholas R.Wagstaff, Simon C.Wüster, WolfgangCook, Darren A. N.Bolton, Fiona M. S.King, Sarah I.Pla, DaviniaSanz, LibiaCalvete, Juan J.Harrison, Robert A.Cerastes cerastesEchis pyramidum leakeyiVenomEchis carinatus sochurekiBitis arietansEchis coloratusEchis ocellatuscrisp_dna DNA alignment of the cysteine rich secretory protein (CRISP) toxin family LAAO_dna DNA alignment of the L-amino acid oxidase (LAAO) toxin family lectin_dna DNA alignment of the C-type lectin (CTL) toxin family pla2_dna DNA alignment of the phospholipase A2 (PLA2) toxin family serine_protease_dna DNA alignment of the serine protease (SP) toxin family svmp_dna DNA alignment of the snake venom metalloproteinase (SVMP) toxin familyVariation in venom composition is a ubiquitous phenomenon in snakes and occurs both interspecifically and intraspecifically. Venom variation can have severe outcomes for snakebite victims by rendering the specific antibodies found in antivenoms ineffective against heterologous toxins found in different venoms. The rapid evolutionary expansion of different toxin-encoding gene families in different snake lineages is widely perceived as the main cause of venom variation. However, this view is simplistic and disregards the understudied influence that processes acting on gene transcription and translation may have on the production of the venom proteome. Here, we assess the venom composition of six related viperid snakes and compare interspecific changes in the number of toxin genes, their transcription in the venom gland, and their translation into proteins secreted in venom. Our results reveal that multiple levels of regulation are responsible for generating variation in venom composition between related snake species. We demonstrate that differential levels of toxin transcription, translation, and their posttranslational modification have a substantial impact upon the resulting venom protein mixture. Notably, these processes act to varying extents on different toxin paralogs found in different snakes and are therefore likely to be as important as ancestral gene duplication events for generating compositionally distinct venom proteomes. Our results suggest that these processes may also contribute to altering the toxicity of snake venoms, and we demonstrate how this variability can undermine the treatment of a neglected tropical disease, snakebite.Peer reviewedDryadConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202220222015info:eu-repo/semantics/datasethttp://purl.org/coar/resource_type/c_ddb1fashttp://hdl.handle.net/10261/282293http://datadryad.org/stash/dataset/doi:10.5061/dryad.1j292reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésCasewell, Nicholas R.; Wagstaff, Simon C.; Wüster, Wolfgang; Cook, Darren A. N.; Bolton, Fiona M. S.; King, Sarah I.; Pla, Davinia; Sanz, Libia; Calvete, Juan J.; Harrison, Robert A. (2015): Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms; http://dx.doi.org/10.1073/pnas.1405484111. http://hdl.handle.net/10261/99377https://doi.org/10.5061/dryad.1j292Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2822932026-05-22T06:33:51Z
dc.title.none.fl_str_mv Data from: Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms
title Data from: Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms
spellingShingle Data from: Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms
Casewell, Nicholas R.
Cerastes cerastes
Echis pyramidum leakeyi
Venom
Echis carinatus sochureki
Bitis arietans
Echis coloratus
Echis ocellatus
title_short Data from: Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms
title_full Data from: Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms
title_fullStr Data from: Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms
title_full_unstemmed Data from: Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms
title_sort Data from: Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms
dc.creator.none.fl_str_mv Casewell, Nicholas R.
Wagstaff, Simon C.
Wüster, Wolfgang
Cook, Darren A. N.
Bolton, Fiona M. S.
King, Sarah I.
Pla, Davinia
Sanz, Libia
Calvete, Juan J.
Harrison, Robert A.
author Casewell, Nicholas R.
author_facet Casewell, Nicholas R.
Wagstaff, Simon C.
Wüster, Wolfgang
Cook, Darren A. N.
Bolton, Fiona M. S.
King, Sarah I.
Pla, Davinia
Sanz, Libia
Calvete, Juan J.
Harrison, Robert A.
author_role author
author2 Wagstaff, Simon C.
Wüster, Wolfgang
Cook, Darren A. N.
Bolton, Fiona M. S.
King, Sarah I.
Pla, Davinia
Sanz, Libia
Calvete, Juan J.
Harrison, Robert A.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Cerastes cerastes
Echis pyramidum leakeyi
Venom
Echis carinatus sochureki
Bitis arietans
Echis coloratus
Echis ocellatus
topic Cerastes cerastes
Echis pyramidum leakeyi
Venom
Echis carinatus sochureki
Bitis arietans
Echis coloratus
Echis ocellatus
description crisp_dna DNA alignment of the cysteine rich secretory protein (CRISP) toxin family LAAO_dna DNA alignment of the L-amino acid oxidase (LAAO) toxin family lectin_dna DNA alignment of the C-type lectin (CTL) toxin family pla2_dna DNA alignment of the phospholipase A2 (PLA2) toxin family serine_protease_dna DNA alignment of the serine protease (SP) toxin family svmp_dna DNA alignment of the snake venom metalloproteinase (SVMP) toxin family
publishDate 2015
dc.date.none.fl_str_mv 2015
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/dataset
http://purl.org/coar/resource_type/c_ddb1
format dataset
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/282293
http://datadryad.org/stash/dataset/doi:10.5061/dryad.1j292
url http://hdl.handle.net/10261/282293
http://datadryad.org/stash/dataset/doi:10.5061/dryad.1j292
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Casewell, Nicholas R.; Wagstaff, Simon C.; Wüster, Wolfgang; Cook, Darren A. N.; Bolton, Fiona M. S.; King, Sarah I.; Pla, Davinia; Sanz, Libia; Calvete, Juan J.; Harrison, Robert A. (2015): Medically important differences in snake venom composition are dictated by distinct postgenomic mechanisms; http://dx.doi.org/10.1073/pnas.1405484111. http://hdl.handle.net/10261/99377
https://doi.org/10.5061/dryad.1j292
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv fas
dc.publisher.none.fl_str_mv Dryad
publisher.none.fl_str_mv Dryad
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419477166194688
score 15,811543

Similares en LA Referencia