From embryos to embryoids: How external signals and self-organization drive embryonic development

Embryonic development has been traditionally seen as an inductive process directed by exogenous maternal inputs and extra-embryonic signals. Increasing evidence, however, is showing that, in addition to exogenous signals, the development of the embryo involves endogenous self-organization. Recently,...

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Detalles Bibliográficos
Autores: Serrano Morales, J., Raspopovic, Jelena, Marcon, Luciano
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/260096
Acceso en línea:http://hdl.handle.net/10261/260096
Access Level:acceso abierto
Palabra clave:Self-organization
Self-assembly
Micropattern colonies
Embryoid bodies
Turing patterning
Reaction-diffusion
Synthetic embryology
Gastruloids
Symmetry breaking, induction
Embryonic stem cells (ESCs)
Extra-embryonic stem cell
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spelling From embryos to embryoids: How external signals and self-organization drive embryonic developmentSerrano Morales, J.Raspopovic, JelenaMarcon, LucianoSelf-organizationSelf-assemblyMicropattern coloniesEmbryoid bodiesTuring patterningReaction-diffusionSynthetic embryologyGastruloidsSymmetry breaking, inductionEmbryonic stem cells (ESCs)Extra-embryonic stem cellEmbryonic development has been traditionally seen as an inductive process directed by exogenous maternal inputs and extra-embryonic signals. Increasing evidence, however, is showing that, in addition to exogenous signals, the development of the embryo involves endogenous self-organization. Recently, this self-organizing potential has been highlighted by a number of stem cell models known as embryoids that can recapitulate different aspects of embryogenesis in vitro. Here, we review the self-organizing behaviors observed in different embryoid models and seek to reconcile this new evidence with classical knowledge of developmental biology. This analysis leads to reexamine embryonic development as a guided self-organizing process, where patterning and morphogenesis are controlled by a combination of exogenous signals and endogenous self-organization. Finally, we discuss the multidisciplinary approach required to investigate the genetic and cellular basis of self-organization.This work is supported by grant PGC2018-095170-A-100 from the Spanish Ministry of Science and Innovation, Spain. J.R. is supported by a Juan de la Cierva postdoctoral fellowship IJCI-2017-32275 and J.S. is supported by a doctoral fellowship PRE2018-085766, from the Spanish Ministry of Science and Innovation, Spain.Cell PressMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/260096reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/PGC2018-095170-A-100/info:eu-repo/grantAgreement/AEI/IJCI-2017-32275/info:eu-repo/grantAgreement/AEI/PRE2018-085766/http://dx.doi.org/10.1016/j.stemcr.2021.03.026Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2600962026-05-22T06:33:51Z
dc.title.none.fl_str_mv From embryos to embryoids: How external signals and self-organization drive embryonic development
title From embryos to embryoids: How external signals and self-organization drive embryonic development
spellingShingle From embryos to embryoids: How external signals and self-organization drive embryonic development
Serrano Morales, J.
Self-organization
Self-assembly
Micropattern colonies
Embryoid bodies
Turing patterning
Reaction-diffusion
Synthetic embryology
Gastruloids
Symmetry breaking, induction
Embryonic stem cells (ESCs)
Extra-embryonic stem cell
title_short From embryos to embryoids: How external signals and self-organization drive embryonic development
title_full From embryos to embryoids: How external signals and self-organization drive embryonic development
title_fullStr From embryos to embryoids: How external signals and self-organization drive embryonic development
title_full_unstemmed From embryos to embryoids: How external signals and self-organization drive embryonic development
title_sort From embryos to embryoids: How external signals and self-organization drive embryonic development
dc.creator.none.fl_str_mv Serrano Morales, J.
Raspopovic, Jelena
Marcon, Luciano
author Serrano Morales, J.
author_facet Serrano Morales, J.
Raspopovic, Jelena
Marcon, Luciano
author_role author
author2 Raspopovic, Jelena
Marcon, Luciano
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Self-organization
Self-assembly
Micropattern colonies
Embryoid bodies
Turing patterning
Reaction-diffusion
Synthetic embryology
Gastruloids
Symmetry breaking, induction
Embryonic stem cells (ESCs)
Extra-embryonic stem cell
topic Self-organization
Self-assembly
Micropattern colonies
Embryoid bodies
Turing patterning
Reaction-diffusion
Synthetic embryology
Gastruloids
Symmetry breaking, induction
Embryonic stem cells (ESCs)
Extra-embryonic stem cell
description Embryonic development has been traditionally seen as an inductive process directed by exogenous maternal inputs and extra-embryonic signals. Increasing evidence, however, is showing that, in addition to exogenous signals, the development of the embryo involves endogenous self-organization. Recently, this self-organizing potential has been highlighted by a number of stem cell models known as embryoids that can recapitulate different aspects of embryogenesis in vitro. Here, we review the self-organizing behaviors observed in different embryoid models and seek to reconcile this new evidence with classical knowledge of developmental biology. This analysis leads to reexamine embryonic development as a guided self-organizing process, where patterning and morphogenesis are controlled by a combination of exogenous signals and endogenous self-organization. Finally, we discuss the multidisciplinary approach required to investigate the genetic and cellular basis of self-organization.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/260096
url http://hdl.handle.net/10261/260096
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/PGC2018-095170-A-100/
info:eu-repo/grantAgreement/AEI/IJCI-2017-32275/
info:eu-repo/grantAgreement/AEI/PRE2018-085766/
http://dx.doi.org/10.1016/j.stemcr.2021.03.026
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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repository.mail.fl_str_mv
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