Targeting human urinary metabolome by LC-MS/MS: a review

Urine is a biological matrix that contains hundreds of metabolic end products which constitute the urinary metabolome. The development and advances on LC-MS/MS have revolutionized the analytical study of biomolecules by enabling their accurate identification and quantification in an unprecedented ma...

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Detalles Bibliográficos
Autores: Rodríguez-Morató, Jose, 1987-, Pozo Mendoza, Óscar J., 1975-, Marcos del Águila, Josep, 1971-
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/52752
Acceso en línea:http://hdl.handle.net/10230/52752
http://dx.doi.org/10.4155/bio-2017-0285
Access Level:acceso abierto
Palabra clave:LC–MS/MS
Amino acids
Lipids
Neurotransmitters
Quantitation
Steroids
Targeted metabolomics
Untargeted metabolomics
Urine
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spelling Targeting human urinary metabolome by LC-MS/MS: a reviewRodríguez-Morató, Jose, 1987-Pozo Mendoza, Óscar J., 1975-Marcos del Águila, Josep, 1971-LC–MS/MSAmino acidsLipidsNeurotransmittersQuantitationSteroidsTargeted metabolomicsUntargeted metabolomicsUrineUrine is a biological matrix that contains hundreds of metabolic end products which constitute the urinary metabolome. The development and advances on LC-MS/MS have revolutionized the analytical study of biomolecules by enabling their accurate identification and quantification in an unprecedented manner. Nowadays, LC-MS/MS is helping to unveil the complexity of urine metabolome, and the results obtained have multiple biomedical applications. This review focuses on the targeted LC-MS/MS analysis of the urine metabolome. In the first part, we describe general considerations (from sample collection to quantitation) required for a proper targeted metabolic analysis. In the second part, we address the urinary analysis and recent applications of four relevant families: amino acids, catecholamines, lipids and steroids.J Rodríguez-Morató acknowledges funding from the EU's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 712949 (TECNIOspring PLUS) and from the Agency for Business Competitiveness of the Government of Catalonia. Spanish Health National System is acknowledged for O J Pozo contract (CPII16/00027). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.Future Science202220222018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/52752http://dx.doi.org/10.4155/bio-2017-0285reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésBioanalysis. 2018 Apr 1;10(7):489-516info:eu-repo/grantAgreement/EC/H2020/712949This is the author's final version of the following article: Rodríguez-Morató J, Pozo ÓJ, Marcos J. Targeting human urinary metabolome by LC-MS/MS: a review. Bioanalysis. 2018 Apr 1;10(7):489-516. DOI: 10.4155/bio-2017-0285, which has been published in final form at http://dx.doi.org/10.4155/bio-2017-0285.info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/527522026-06-12T07:21:37Z
dc.title.none.fl_str_mv Targeting human urinary metabolome by LC-MS/MS: a review
title Targeting human urinary metabolome by LC-MS/MS: a review
spellingShingle Targeting human urinary metabolome by LC-MS/MS: a review
Rodríguez-Morató, Jose, 1987-
LC–MS/MS
Amino acids
Lipids
Neurotransmitters
Quantitation
Steroids
Targeted metabolomics
Untargeted metabolomics
Urine
title_short Targeting human urinary metabolome by LC-MS/MS: a review
title_full Targeting human urinary metabolome by LC-MS/MS: a review
title_fullStr Targeting human urinary metabolome by LC-MS/MS: a review
title_full_unstemmed Targeting human urinary metabolome by LC-MS/MS: a review
title_sort Targeting human urinary metabolome by LC-MS/MS: a review
dc.creator.none.fl_str_mv Rodríguez-Morató, Jose, 1987-
Pozo Mendoza, Óscar J., 1975-
Marcos del Águila, Josep, 1971-
author Rodríguez-Morató, Jose, 1987-
author_facet Rodríguez-Morató, Jose, 1987-
Pozo Mendoza, Óscar J., 1975-
Marcos del Águila, Josep, 1971-
author_role author
author2 Pozo Mendoza, Óscar J., 1975-
Marcos del Águila, Josep, 1971-
author2_role author
author
dc.subject.none.fl_str_mv LC–MS/MS
Amino acids
Lipids
Neurotransmitters
Quantitation
Steroids
Targeted metabolomics
Untargeted metabolomics
Urine
topic LC–MS/MS
Amino acids
Lipids
Neurotransmitters
Quantitation
Steroids
Targeted metabolomics
Untargeted metabolomics
Urine
description Urine is a biological matrix that contains hundreds of metabolic end products which constitute the urinary metabolome. The development and advances on LC-MS/MS have revolutionized the analytical study of biomolecules by enabling their accurate identification and quantification in an unprecedented manner. Nowadays, LC-MS/MS is helping to unveil the complexity of urine metabolome, and the results obtained have multiple biomedical applications. This review focuses on the targeted LC-MS/MS analysis of the urine metabolome. In the first part, we describe general considerations (from sample collection to quantitation) required for a proper targeted metabolic analysis. In the second part, we address the urinary analysis and recent applications of four relevant families: amino acids, catecholamines, lipids and steroids.
publishDate 2018
dc.date.none.fl_str_mv 2018
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/52752
http://dx.doi.org/10.4155/bio-2017-0285
url http://hdl.handle.net/10230/52752
http://dx.doi.org/10.4155/bio-2017-0285
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Bioanalysis. 2018 Apr 1;10(7):489-516
info:eu-repo/grantAgreement/EC/H2020/712949
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Future Science
publisher.none.fl_str_mv Future Science
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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