Short-term outcomes by chronic betablocker treatment in patients presenting to emergency departments with acute heart failure: BB-EAHFE

Aims: to evaluate the association between chronic treatment with betablockers (BB) and the severity of decompensation and short-term outcomes of patients with acute heart failure (AHF). Methods and results: we consecutively included all patients presenting with AHF to 45 Spanish emergency department...

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Autores: Jacob, Javier, Haro, Antoni, Tost, Josep, Rosselló, Xavier, Llorens, Pere, Herrero-Puente, Pablo, Martín-Sánchez, Francisco J., Gil, Víctor, López-Grima, María Luisa, Millán, Javier, Aguirre Tejedo, Alfons, Garrido, José Manuel, Calvo-Rodríguez, Rafael, Pérez-Llantada, Enrique, Sánchez-Nicolás, José Andrés, Mir, María, Rodríguez-Adrada, Esther, Fuentes-De Frutos, Marta, Roset, Alex, Miró, Òscar
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/55606
Acceso en línea:http://hdl.handle.net/10230/55606
http://dx.doi.org/10.1093/ehjacc/zuac100
Access Level:acceso abierto
Palabra clave:Acute heart failure
Betablockers chronic
Mortality
Outcomes
Prognosis
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spelling Short-term outcomes by chronic betablocker treatment in patients presenting to emergency departments with acute heart failure: BB-EAHFEJacob, JavierHaro, AntoniTost, JosepRosselló, XavierLlorens, PereHerrero-Puente, PabloMartín-Sánchez, Francisco J.Gil, VíctorLópez-Grima, María LuisaMillán, JavierAguirre Tejedo, AlfonsGarrido, José ManuelCalvo-Rodríguez, RafaelPérez-Llantada, EnriqueSánchez-Nicolás, José AndrésMir, MaríaRodríguez-Adrada, EstherFuentes-De Frutos, MartaRoset, AlexMiró, ÒscarAcute heart failureBetablockers chronicMortalityOutcomesPrognosisAims: to evaluate the association between chronic treatment with betablockers (BB) and the severity of decompensation and short-term outcomes of patients with acute heart failure (AHF). Methods and results: we consecutively included all patients presenting with AHF to 45 Spanish emergency departments (ED) during six different time-periods between 2007 and 2018. Patients were stratified according to whether they were on chronic treatment with BB at the time of ED consultation. Those receiving BB were compared (adjusted odds ratio-OR-with 95% confidence interval-CI-) with those not receiving BB group in terms of in-hospital and 7-day all-cause mortality, need for hospitalization, and prolonged length of stay (≥7 days). Among the 17 923 recruited patients (median age: 80 years; 56% women), 7795 (43%) were on chronic treatment with BB. Based on the MEESSI-AHF risk score, those on BB were at lower risk. In-hospital mortality was observed in 1310 patients (7.4%), 7-day mortality in 765 (4.3%), need for hospitalization in 13 428 (75.0%), and prolonged length of stay (43.3%). After adjustment for confounding, those on chronic BB were at lower risk for in-hospital all-cause mortality (OR = 0.85, 95% CI = 0.79-0.92, P < 0.001); 7-day all-cause mortality (OR = 0.77, 95% CI = 0.70-0.85, P < 0.001); need for hospitalization (OR = 0.89, 95% CI = 0.85-0.94, P < 0.001); prolonged length of stay (OR = 0.90, 95% CI = 0.86-0.94, P < 0.001). A propensity matching approach yielded consistent findings. Conclusion: in patients presenting to ED with AHF, those on BB had better short-term outcomes than those not receiving BB.Oxford University Press20232022info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/55606http://dx.doi.org/10.1093/ehjacc/zuac100reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)Inglés© Oxford University Press. This is a pre-copyedited, author-produced version of an article accepted for publication in European heart journal. Acute cardiovascular care following peer review. The version of record Jacob J, Haro A, Tost J, Rossello X, Llorens P, Herrero P, et al. Short-term outcomes by chronic betablocker treatment in patients presenting to emergency departments with acute heart failure: BB-EAHFE. Eur Heart J Acute Cardiovasc Care. 2022 Nov 2; 11(10): 761-71, is available online at: Jacob J, Haro A, Tost J, Rossello X, Llorens P, Herrero P, et al. Short-term outcomes by chronic betablocker treatment in patients presenting to emergency departments with acute heart failure: BB-EAHFE. Eur Heart J Acute Cardiovasc Care. 2022 Nov 2; 11(10): 761-71. https://academic.oup.com/ehjacc/article-abstract/11/10/761/6677201?redirectedFrom=fulltext&login=true. DOI: 10.1093/ehjacc/zuac100.info:eu-repo/semantics/openAccessoai:recercat.cat:10230/556062026-05-29T05:05:01Z
dc.title.none.fl_str_mv Short-term outcomes by chronic betablocker treatment in patients presenting to emergency departments with acute heart failure: BB-EAHFE
title Short-term outcomes by chronic betablocker treatment in patients presenting to emergency departments with acute heart failure: BB-EAHFE
spellingShingle Short-term outcomes by chronic betablocker treatment in patients presenting to emergency departments with acute heart failure: BB-EAHFE
Jacob, Javier
Acute heart failure
Betablockers chronic
Mortality
Outcomes
Prognosis
title_short Short-term outcomes by chronic betablocker treatment in patients presenting to emergency departments with acute heart failure: BB-EAHFE
title_full Short-term outcomes by chronic betablocker treatment in patients presenting to emergency departments with acute heart failure: BB-EAHFE
title_fullStr Short-term outcomes by chronic betablocker treatment in patients presenting to emergency departments with acute heart failure: BB-EAHFE
title_full_unstemmed Short-term outcomes by chronic betablocker treatment in patients presenting to emergency departments with acute heart failure: BB-EAHFE
title_sort Short-term outcomes by chronic betablocker treatment in patients presenting to emergency departments with acute heart failure: BB-EAHFE
dc.creator.none.fl_str_mv Jacob, Javier
Haro, Antoni
Tost, Josep
Rosselló, Xavier
Llorens, Pere
Herrero-Puente, Pablo
Martín-Sánchez, Francisco J.
Gil, Víctor
López-Grima, María Luisa
Millán, Javier
Aguirre Tejedo, Alfons
Garrido, José Manuel
Calvo-Rodríguez, Rafael
Pérez-Llantada, Enrique
Sánchez-Nicolás, José Andrés
Mir, María
Rodríguez-Adrada, Esther
Fuentes-De Frutos, Marta
Roset, Alex
Miró, Òscar
author Jacob, Javier
author_facet Jacob, Javier
Haro, Antoni
Tost, Josep
Rosselló, Xavier
Llorens, Pere
Herrero-Puente, Pablo
Martín-Sánchez, Francisco J.
Gil, Víctor
López-Grima, María Luisa
Millán, Javier
Aguirre Tejedo, Alfons
Garrido, José Manuel
Calvo-Rodríguez, Rafael
Pérez-Llantada, Enrique
Sánchez-Nicolás, José Andrés
Mir, María
Rodríguez-Adrada, Esther
Fuentes-De Frutos, Marta
Roset, Alex
Miró, Òscar
author_role author
author2 Haro, Antoni
Tost, Josep
Rosselló, Xavier
Llorens, Pere
Herrero-Puente, Pablo
Martín-Sánchez, Francisco J.
Gil, Víctor
López-Grima, María Luisa
Millán, Javier
Aguirre Tejedo, Alfons
Garrido, José Manuel
Calvo-Rodríguez, Rafael
Pérez-Llantada, Enrique
Sánchez-Nicolás, José Andrés
Mir, María
Rodríguez-Adrada, Esther
Fuentes-De Frutos, Marta
Roset, Alex
Miró, Òscar
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Acute heart failure
Betablockers chronic
Mortality
Outcomes
Prognosis
topic Acute heart failure
Betablockers chronic
Mortality
Outcomes
Prognosis
description Aims: to evaluate the association between chronic treatment with betablockers (BB) and the severity of decompensation and short-term outcomes of patients with acute heart failure (AHF). Methods and results: we consecutively included all patients presenting with AHF to 45 Spanish emergency departments (ED) during six different time-periods between 2007 and 2018. Patients were stratified according to whether they were on chronic treatment with BB at the time of ED consultation. Those receiving BB were compared (adjusted odds ratio-OR-with 95% confidence interval-CI-) with those not receiving BB group in terms of in-hospital and 7-day all-cause mortality, need for hospitalization, and prolonged length of stay (≥7 days). Among the 17 923 recruited patients (median age: 80 years; 56% women), 7795 (43%) were on chronic treatment with BB. Based on the MEESSI-AHF risk score, those on BB were at lower risk. In-hospital mortality was observed in 1310 patients (7.4%), 7-day mortality in 765 (4.3%), need for hospitalization in 13 428 (75.0%), and prolonged length of stay (43.3%). After adjustment for confounding, those on chronic BB were at lower risk for in-hospital all-cause mortality (OR = 0.85, 95% CI = 0.79-0.92, P < 0.001); 7-day all-cause mortality (OR = 0.77, 95% CI = 0.70-0.85, P < 0.001); need for hospitalization (OR = 0.89, 95% CI = 0.85-0.94, P < 0.001); prolonged length of stay (OR = 0.90, 95% CI = 0.86-0.94, P < 0.001). A propensity matching approach yielded consistent findings. Conclusion: in patients presenting to ED with AHF, those on BB had better short-term outcomes than those not receiving BB.
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/55606
http://dx.doi.org/10.1093/ehjacc/zuac100
url http://hdl.handle.net/10230/55606
http://dx.doi.org/10.1093/ehjacc/zuac100
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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