Single-chain polymer nanoparticles for oil solubilization

Data will be made available on request.

Detalhes bibliográficos
Autores: Arena, Davide, Miranda, José Ignacio, Lutz-Bueno, Viviane, Moreno Segurado, Ángel J., Pomposo, José A., Malo de Molina, Paula
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2026
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/416588
Acesso em linha:http://hdl.handle.net/10261/416588
Access Level:acceso abierto
Palavra-chave:Single-chain nanoparticles
Oil nanocarrier
Amphiphilic random copolymer
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spelling Single-chain polymer nanoparticles for oil solubilizationArena, DavideMiranda, José IgnacioLutz-Bueno, VivianeMoreno Segurado, Ángel J.Pomposo, José A.Malo de Molina, PaulaSingle-chain nanoparticlesOil nanocarrierAmphiphilic random copolymerData will be made available on request.We report on the oil solubilization of amphiphilic single chain nanoparticles (SCNPs) based on random copolymers composed of oligo(ethyleneglycol) methacrylate (OEGMA) and anthracene methacrylate (AnMA). Small-angle X-ray scattering (SAXS) combined with molecular dynamics simulations reveal that the copolymers self-assemble into single-chain nanoparticles resembling flexible cylinders, driven by the intra-molecular association of anthracene moieties. Higher AnMA content results in shorter, thicker worm-like structures due to enhanced compaction along their length. Despite their amphiphilic nature, the SCNPs remain as isolated entities without forming inter-chain aggregates. This stability is attributed to the steric repulsion imparted by the OEGMA segments, which prevents bridging or clustering even in the semidilute regime. SAXS and small angle neutron scattering (SANS) contrast-variation experiments revealed that toluene incorporation causes only a slight thickening of the cylindrical cross-section, without major changes in overall structure. Complementary diffusion nuclear magnetic resonance (NMR) confirmed successful solubilization of toluene within the single-chain nanoparticles. These findings underline the potential of amphiphilic SCNPs as oil nanocarriers, offering insights into the molecular architecture aspects that influence microstructure and stability.The authors are grateful to the European Synchrotron Radiation Facility, ESRF, for allocating beamtime at BM29. We would like to thank Dr. Hayden Fisher and Dr. Petra Pernot for assistance and support in using the beamline. We also thank the University of the Basque Country (UPV/EHU) for the technical and human support provided by the SGIker NMR Services. We acknowledge the financial support by Eusko Jaurlaritza−Basque Government (Grant IT-1566-22) and Gipuzkoako Foru Aldundia, Programa Red Gipuzkoana de Ciencia, Tecnología e Innovación (2024-CIE4-000014-01). PMM acknowledges grant PID2024-159071NA-I00; and AJM and JAP grant PID2024-157988NB-I00, both funded by MCIN/AEI/10.13039/501100011033 and by ERDF, EU.Peer reviewedElsevierEuropean Synchrotron Radiation FacilityUniversidad del País VascoEusko JaurlaritzaAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)Diputación Foral de GipuzkoaEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262026info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/416588reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2024-2027/PID2024-159071NA-I00info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2024-2027/PID2024-157988NB-I00Arena, Davide; Miranda, José Ignacio; Lutz-Bueno, Viviane; Moreno Segurado, Ángel J.; Pomposo, José A.; Malo de Molina, Paula; 2026; Supporting Information: Single-chain polymer nanoparticles for oil solubilization [Dataset]; Elsevier; https://doi.org/10.1016/j.jcis.2025.139395https://doi.org/10.1016/j.jcis.2025.139395Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4165882026-05-22T06:33:51Z
dc.title.none.fl_str_mv Single-chain polymer nanoparticles for oil solubilization
title Single-chain polymer nanoparticles for oil solubilization
spellingShingle Single-chain polymer nanoparticles for oil solubilization
Arena, Davide
Single-chain nanoparticles
Oil nanocarrier
Amphiphilic random copolymer
title_short Single-chain polymer nanoparticles for oil solubilization
title_full Single-chain polymer nanoparticles for oil solubilization
title_fullStr Single-chain polymer nanoparticles for oil solubilization
title_full_unstemmed Single-chain polymer nanoparticles for oil solubilization
title_sort Single-chain polymer nanoparticles for oil solubilization
dc.creator.none.fl_str_mv Arena, Davide
Miranda, José Ignacio
Lutz-Bueno, Viviane
Moreno Segurado, Ángel J.
Pomposo, José A.
Malo de Molina, Paula
author Arena, Davide
author_facet Arena, Davide
Miranda, José Ignacio
Lutz-Bueno, Viviane
Moreno Segurado, Ángel J.
Pomposo, José A.
Malo de Molina, Paula
author_role author
author2 Miranda, José Ignacio
Lutz-Bueno, Viviane
Moreno Segurado, Ángel J.
Pomposo, José A.
Malo de Molina, Paula
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv European Synchrotron Radiation Facility
Universidad del País Vasco
Eusko Jaurlaritza
Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
Diputación Foral de Gipuzkoa
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Single-chain nanoparticles
Oil nanocarrier
Amphiphilic random copolymer
topic Single-chain nanoparticles
Oil nanocarrier
Amphiphilic random copolymer
description Data will be made available on request.
publishDate 2026
dc.date.none.fl_str_mv 2026
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/416588
url http://hdl.handle.net/10261/416588
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2024-2027/PID2024-159071NA-I00
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2024-2027/PID2024-157988NB-I00
Arena, Davide; Miranda, José Ignacio; Lutz-Bueno, Viviane; Moreno Segurado, Ángel J.; Pomposo, José A.; Malo de Molina, Paula; 2026; Supporting Information: Single-chain polymer nanoparticles for oil solubilization [Dataset]; Elsevier; https://doi.org/10.1016/j.jcis.2025.139395
https://doi.org/10.1016/j.jcis.2025.139395
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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