Pattern-sensitive neurons reveal encoding of complex auditory regularities in the rat inferior colliculus

A ‘pattern alternation paradigm’ has been previously used in human ERP recordings to investigate the brain encoding of complex auditory regularities, but prior studies on regularity encoding in animal models to examine mechanisms of adaptation of auditory neuronal responses have used primarily oddba...

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Autores: Malmierca, Manuel S., Niño Aguillón, Blanca Edilma, Nieto Diego, Javier, Porteros Herrero, Ángel Fernando, Pérez González, David, Escera, Carles
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/160459
Acceso en línea:http://hdl.handle.net/10366/160459
Access Level:acceso abierto
Palabra clave:Auditory midbrain
Single unit recordings
Pattern alternation paradigm
SSA
MMN
Predictive coding
Inferior Colliculi
2490 Neurociencias
2411.13 Fisiología de la Audición
colículos inferiores
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oai_identifier_str oai:gredos.usal.es:10366/160459
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spelling Pattern-sensitive neurons reveal encoding of complex auditory regularities in the rat inferior colliculusMalmierca, Manuel S.Niño Aguillón, Blanca EdilmaNieto Diego, JavierPorteros Herrero, Ángel FernandoPérez González, DavidEscera, CarlesAuditory midbrainSingle unit recordingsPattern alternation paradigmSSAMMNPredictive codingInferior Colliculi2490 Neurociencias2411.13 Fisiología de la Audicióncolículos inferioresA ‘pattern alternation paradigm’ has been previously used in human ERP recordings to investigate the brain encoding of complex auditory regularities, but prior studies on regularity encoding in animal models to examine mechanisms of adaptation of auditory neuronal responses have used primarily oddball stimulus sequences to study stimulus-specific adaptation alone. In order to examine the sensitivity of neuronal adaptation to expected and unexpected events embedded in a complex sound sequence, we used a similar patterned sequence of sounds. We recorded single unit activity and compared neuronal responses in the rat inferior colliculus (IC) to sound stimuli conforming to pattern alternation regularity with those to stimuli in which occasional sound repetitions violated that alternation. Results show that some neurons in the rat inferior colliculus are sensitive to the history of patterned stimulation and to violations of patterned regularity, demonstrating that there is a population of subcortical neurons, located as early as the level of the midbrain, that can detect more complex stimulus regularities than previously supposed and that are as sensitive to complex statistics as some neurons in primary auditory cortex. Our findings indicate that these pattern-sensitive neurons can extract temporal and spectral regularities between successive acoustic stimuli. This is important because the extraction of regularities from the sound sequences will result in the development of expectancies for future sounds and hence, the present results are compatible with predictive coding models. Our results demonstrate that some collicular neurons, located as early as in the midbrain level, are involved in the generation and shaping of prediction errors in ways not previously considered and thus, the present findings challenge the prevailing view that perceptual organization of sound only emerges at the auditory cortex level.Ministerio de Economía y Competitividad - MINECO/FEDER (SAF2016-75803-P) Ministerio de Economía y Competitividad - MINECO/FEDER (PSI2015-63664-P) Generalitat de Catalunya (SGR2017-974) ICREA Acadèmia Junta de Castilla y León - JCYL (Operational Programme ESF Castilla y León 2007–2013)Ministerio de Economía y CompetitividadGeneralitat de CatalunyaJunta de Castilla y LeónElsevier202420242019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/160459reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésMinisterio de Economía y Competitividad - MINECO/FEDER (SAF2016-75803-P)Ministerio de Economía y Competitividad - MINECO/FEDER (PSI2015-63664-P)Generalitat de Catalunya (SGR2017-974)Junta de Castilla y León - JCYL (Operational Programme ESF Castilla y León 2007–2013)Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1604592026-06-07T06:28:51Z
dc.title.none.fl_str_mv Pattern-sensitive neurons reveal encoding of complex auditory regularities in the rat inferior colliculus
title Pattern-sensitive neurons reveal encoding of complex auditory regularities in the rat inferior colliculus
spellingShingle Pattern-sensitive neurons reveal encoding of complex auditory regularities in the rat inferior colliculus
Malmierca, Manuel S.
Auditory midbrain
Single unit recordings
Pattern alternation paradigm
SSA
MMN
Predictive coding
Inferior Colliculi
2490 Neurociencias
2411.13 Fisiología de la Audición
colículos inferiores
title_short Pattern-sensitive neurons reveal encoding of complex auditory regularities in the rat inferior colliculus
title_full Pattern-sensitive neurons reveal encoding of complex auditory regularities in the rat inferior colliculus
title_fullStr Pattern-sensitive neurons reveal encoding of complex auditory regularities in the rat inferior colliculus
title_full_unstemmed Pattern-sensitive neurons reveal encoding of complex auditory regularities in the rat inferior colliculus
title_sort Pattern-sensitive neurons reveal encoding of complex auditory regularities in the rat inferior colliculus
dc.creator.none.fl_str_mv Malmierca, Manuel S.
Niño Aguillón, Blanca Edilma
Nieto Diego, Javier
Porteros Herrero, Ángel Fernando
Pérez González, David
Escera, Carles
author Malmierca, Manuel S.
author_facet Malmierca, Manuel S.
Niño Aguillón, Blanca Edilma
Nieto Diego, Javier
Porteros Herrero, Ángel Fernando
Pérez González, David
Escera, Carles
author_role author
author2 Niño Aguillón, Blanca Edilma
Nieto Diego, Javier
Porteros Herrero, Ángel Fernando
Pérez González, David
Escera, Carles
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Auditory midbrain
Single unit recordings
Pattern alternation paradigm
SSA
MMN
Predictive coding
Inferior Colliculi
2490 Neurociencias
2411.13 Fisiología de la Audición
colículos inferiores
topic Auditory midbrain
Single unit recordings
Pattern alternation paradigm
SSA
MMN
Predictive coding
Inferior Colliculi
2490 Neurociencias
2411.13 Fisiología de la Audición
colículos inferiores
description A ‘pattern alternation paradigm’ has been previously used in human ERP recordings to investigate the brain encoding of complex auditory regularities, but prior studies on regularity encoding in animal models to examine mechanisms of adaptation of auditory neuronal responses have used primarily oddball stimulus sequences to study stimulus-specific adaptation alone. In order to examine the sensitivity of neuronal adaptation to expected and unexpected events embedded in a complex sound sequence, we used a similar patterned sequence of sounds. We recorded single unit activity and compared neuronal responses in the rat inferior colliculus (IC) to sound stimuli conforming to pattern alternation regularity with those to stimuli in which occasional sound repetitions violated that alternation. Results show that some neurons in the rat inferior colliculus are sensitive to the history of patterned stimulation and to violations of patterned regularity, demonstrating that there is a population of subcortical neurons, located as early as the level of the midbrain, that can detect more complex stimulus regularities than previously supposed and that are as sensitive to complex statistics as some neurons in primary auditory cortex. Our findings indicate that these pattern-sensitive neurons can extract temporal and spectral regularities between successive acoustic stimuli. This is important because the extraction of regularities from the sound sequences will result in the development of expectancies for future sounds and hence, the present results are compatible with predictive coding models. Our results demonstrate that some collicular neurons, located as early as in the midbrain level, are involved in the generation and shaping of prediction errors in ways not previously considered and thus, the present findings challenge the prevailing view that perceptual organization of sound only emerges at the auditory cortex level.
publishDate 2019
dc.date.none.fl_str_mv 2019
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/160459
url http://hdl.handle.net/10366/160459
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad - MINECO/FEDER (SAF2016-75803-P)
Ministerio de Economía y Competitividad - MINECO/FEDER (PSI2015-63664-P)
Generalitat de Catalunya (SGR2017-974)
Junta de Castilla y León - JCYL (Operational Programme ESF Castilla y León 2007–2013)
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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