Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study

Background: Recent multicenter studies identifed COVID-19 as a risk factor for invasive pulmonary aspergillosis (IPA). However, no large multicenter study has compared the incidence of IPA between COVID-19 and infuenza patients. Objectives: To determine the incidence of putative IPA in critically il...

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Autores: Rouzé, Anahita, Lemaitre, Elise, Martin Loeches, Ignacio, Povoa, Pedro, Diaz, Emili, Nyga, Rémy, Torres Martí, Antoni, Metzelard, Matthieu, Du Cheyron, Damien, Lambiotte, Fabien, Tamion, Fabienne, Labruyere, Marie, Boulle Geronimi, Claire, Luyt, Charles-Edouard, Nyunga, Martine, Pouly, Olivier, Thille, Arnaud Wilfrid, Megarbane, Bruno, Saade, Anastasia, Magira, Eleni, Llitjos, Jean-François, Ioannidou, Iliana, Pierre, Alexandre, Reignier, Jean, Garot, Denis, Kreitmann, Louis, Baudel, Jean-Luc, Voiriot, Guillaume, Plantefeve, Gaëtan, Morawiec, Elise, Asfar, Pierre, Boyer, Alexandre, Mekontso-Dessap, Armand, Makris, Demosthenes, Vinsonneau, Christophe, Floch, Pierre-Edouard, Marois, Clémence, Ceccato, Adrian, Artigas, Antonio, Gaudet, Alexandre
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2022
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/186710
Acesso em linha:https://hdl.handle.net/2445/186710
Access Level:Acceso aberto
Palavra-chave:COVID-19
Unitats de cures intensives
Grip
Intensive care units
Influenza
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spelling Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort studyRouzé, AnahitaLemaitre, EliseMartin Loeches, IgnacioPovoa, PedroDiaz, EmiliNyga, RémyTorres Martí, AntoniMetzelard, MatthieuDu Cheyron, DamienLambiotte, FabienTamion, FabienneLabruyere, MarieBoulle Geronimi, ClaireLuyt, Charles-EdouardNyunga, MartinePouly, OlivierThille, Arnaud WilfridMegarbane, BrunoSaade, AnastasiaMagira, EleniLlitjos, Jean-FrançoisIoannidou, IlianaPierre, AlexandreReignier, JeanGarot, DenisKreitmann, LouisBaudel, Jean-LucVoiriot, GuillaumePlantefeve, GaëtanMorawiec, EliseAsfar, PierreBoyer, AlexandreMekontso-Dessap, ArmandMakris, DemosthenesVinsonneau, ChristopheFloch, Pierre-EdouardMarois, ClémenceCeccato, AdrianArtigas, AntonioGaudet, AlexandreCOVID-19Unitats de cures intensivesGripCOVID-19Intensive care unitsInfluenzaBackground: Recent multicenter studies identifed COVID-19 as a risk factor for invasive pulmonary aspergillosis (IPA). However, no large multicenter study has compared the incidence of IPA between COVID-19 and infuenza patients. Objectives: To determine the incidence of putative IPA in critically ill SARS-CoV-2 patients, compared with infuenza patients. Methods: This study was a planned ancillary analysis of the coVAPid multicenter retrospective European cohort. Con‑ secutive adult patients requiring invasive mechanical ventilation for>48 h for SARS-CoV-2 pneumonia or infuenza pneumonia were included. The 28-day cumulative incidence of putative IPA, based on Blot defnition, was the primary outcome. IPA incidence was estimated using the Kalbfeisch and Prentice method, considering extubation (dead or alive) within 28 days as competing event. Results: A total of 1047 patients were included (566 in the SARS-CoV-2 group and 481 in the infuenza group). The incidence of putative IPA was lower in SARS-CoV-2 pneumonia group (14, 2.5%) than in infuenza pneumonia group (29, 6%), adjusted cause-specifc hazard ratio (cHR) 3.29 (95% CI 1.53-7.02, p=0.0006). When putative IPA and Aspergillus respiratory tract colonization were combined, the incidence was also signifcantly lower in the SARS-CoV-2 group, as compared to infuenza group (4.1% vs. 10.2%), adjusted cHR 3.21 (95% CI 1.88-5.46, p<0.0001). In the wholeBioMed Central2022202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/186710Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1186/s13054-021-03874-1Critical Care, 2022, vol. 26, num. 1, p. 11-24https://doi.org/10.1186/s13054-021-03874-1cc-by (c) Rouzé, Anahita et al., 2022https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1867102026-05-29T05:05:01Z
dc.title.none.fl_str_mv Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study
title Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study
spellingShingle Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study
Rouzé, Anahita
COVID-19
Unitats de cures intensives
Grip
COVID-19
Intensive care units
Influenza
title_short Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study
title_full Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study
title_fullStr Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study
title_full_unstemmed Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study
title_sort Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study
dc.creator.none.fl_str_mv Rouzé, Anahita
Lemaitre, Elise
Martin Loeches, Ignacio
Povoa, Pedro
Diaz, Emili
Nyga, Rémy
Torres Martí, Antoni
Metzelard, Matthieu
Du Cheyron, Damien
Lambiotte, Fabien
Tamion, Fabienne
Labruyere, Marie
Boulle Geronimi, Claire
Luyt, Charles-Edouard
Nyunga, Martine
Pouly, Olivier
Thille, Arnaud Wilfrid
Megarbane, Bruno
Saade, Anastasia
Magira, Eleni
Llitjos, Jean-François
Ioannidou, Iliana
Pierre, Alexandre
Reignier, Jean
Garot, Denis
Kreitmann, Louis
Baudel, Jean-Luc
Voiriot, Guillaume
Plantefeve, Gaëtan
Morawiec, Elise
Asfar, Pierre
Boyer, Alexandre
Mekontso-Dessap, Armand
Makris, Demosthenes
Vinsonneau, Christophe
Floch, Pierre-Edouard
Marois, Clémence
Ceccato, Adrian
Artigas, Antonio
Gaudet, Alexandre
author Rouzé, Anahita
author_facet Rouzé, Anahita
Lemaitre, Elise
Martin Loeches, Ignacio
Povoa, Pedro
Diaz, Emili
Nyga, Rémy
Torres Martí, Antoni
Metzelard, Matthieu
Du Cheyron, Damien
Lambiotte, Fabien
Tamion, Fabienne
Labruyere, Marie
Boulle Geronimi, Claire
Luyt, Charles-Edouard
Nyunga, Martine
Pouly, Olivier
Thille, Arnaud Wilfrid
Megarbane, Bruno
Saade, Anastasia
Magira, Eleni
Llitjos, Jean-François
Ioannidou, Iliana
Pierre, Alexandre
Reignier, Jean
Garot, Denis
Kreitmann, Louis
Baudel, Jean-Luc
Voiriot, Guillaume
Plantefeve, Gaëtan
Morawiec, Elise
Asfar, Pierre
Boyer, Alexandre
Mekontso-Dessap, Armand
Makris, Demosthenes
Vinsonneau, Christophe
Floch, Pierre-Edouard
Marois, Clémence
Ceccato, Adrian
Artigas, Antonio
Gaudet, Alexandre
author_role author
author2 Lemaitre, Elise
Martin Loeches, Ignacio
Povoa, Pedro
Diaz, Emili
Nyga, Rémy
Torres Martí, Antoni
Metzelard, Matthieu
Du Cheyron, Damien
Lambiotte, Fabien
Tamion, Fabienne
Labruyere, Marie
Boulle Geronimi, Claire
Luyt, Charles-Edouard
Nyunga, Martine
Pouly, Olivier
Thille, Arnaud Wilfrid
Megarbane, Bruno
Saade, Anastasia
Magira, Eleni
Llitjos, Jean-François
Ioannidou, Iliana
Pierre, Alexandre
Reignier, Jean
Garot, Denis
Kreitmann, Louis
Baudel, Jean-Luc
Voiriot, Guillaume
Plantefeve, Gaëtan
Morawiec, Elise
Asfar, Pierre
Boyer, Alexandre
Mekontso-Dessap, Armand
Makris, Demosthenes
Vinsonneau, Christophe
Floch, Pierre-Edouard
Marois, Clémence
Ceccato, Adrian
Artigas, Antonio
Gaudet, Alexandre
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv COVID-19
Unitats de cures intensives
Grip
COVID-19
Intensive care units
Influenza
topic COVID-19
Unitats de cures intensives
Grip
COVID-19
Intensive care units
Influenza
description Background: Recent multicenter studies identifed COVID-19 as a risk factor for invasive pulmonary aspergillosis (IPA). However, no large multicenter study has compared the incidence of IPA between COVID-19 and infuenza patients. Objectives: To determine the incidence of putative IPA in critically ill SARS-CoV-2 patients, compared with infuenza patients. Methods: This study was a planned ancillary analysis of the coVAPid multicenter retrospective European cohort. Con‑ secutive adult patients requiring invasive mechanical ventilation for>48 h for SARS-CoV-2 pneumonia or infuenza pneumonia were included. The 28-day cumulative incidence of putative IPA, based on Blot defnition, was the primary outcome. IPA incidence was estimated using the Kalbfeisch and Prentice method, considering extubation (dead or alive) within 28 days as competing event. Results: A total of 1047 patients were included (566 in the SARS-CoV-2 group and 481 in the infuenza group). The incidence of putative IPA was lower in SARS-CoV-2 pneumonia group (14, 2.5%) than in infuenza pneumonia group (29, 6%), adjusted cause-specifc hazard ratio (cHR) 3.29 (95% CI 1.53-7.02, p=0.0006). When putative IPA and Aspergillus respiratory tract colonization were combined, the incidence was also signifcantly lower in the SARS-CoV-2 group, as compared to infuenza group (4.1% vs. 10.2%), adjusted cHR 3.21 (95% CI 1.88-5.46, p<0.0001). In the whole
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/186710
url https://hdl.handle.net/2445/186710
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1186/s13054-021-03874-1
Critical Care, 2022, vol. 26, num. 1, p. 11-24
https://doi.org/10.1186/s13054-021-03874-1
dc.rights.none.fl_str_mv cc-by (c) Rouzé, Anahita et al., 2022
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Rouzé, Anahita et al., 2022
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (Medicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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