The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development

In female mammals, the two X chromosomes are subject to epigenetic gene regulation in order to balance X-linked gene dosage with autosomes and in relation to males, which have one X and one Y chromosome. This is achieved by an intricate interplay of several processes; X-chromosome inactivation and r...

ver descrição completa

Detalhes bibliográficos
Autores: Mattimoe, Tom, Payer, Bernhard
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2023
País:España
Recursos:Universitat Pompeu Fabra
Repositório:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/57322
Acesso em linha:http://hdl.handle.net/10230/57322
http://dx.doi.org/10.1042/BCJ20220450
Access Level:Acceso aberto
Palavra-chave:X chromosome
Dosage compensation
Epigenetic reprogramming
Germ cell development
id ES_ca0cd7df20d8d7fe5173f37b2b5ccd9d
oai_identifier_str oai:repositori.upf.edu:10230/57322
network_acronym_str ES
network_name_str España
repository_id_str
spelling The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline developmentMattimoe, TomPayer, BernhardX chromosomeDosage compensationEpigenetic reprogrammingGerm cell developmentIn female mammals, the two X chromosomes are subject to epigenetic gene regulation in order to balance X-linked gene dosage with autosomes and in relation to males, which have one X and one Y chromosome. This is achieved by an intricate interplay of several processes; X-chromosome inactivation and reactivation elicit global epigenetic regulation of expression from one X chromosome in a stage-specific manner, whilst the process of X-chromosome upregulation responds to this by fine-tuning transcription levels of the second X. The germline is unique in its function of transmitting both the genetic and epigenetic information from one generation to the next, and remodelling of the X chromosome is one of the key steps in setting the stage for successful development. Here, we provide an overview of the complex dynamics of X-chromosome dosage control during embryonic and germ cell development, and aim to decipher its potential role for normal germline competency.Portland Press202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/57322http://dx.doi.org/10.1042/BCJ20220450reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésBiochem J. 2023 Apr 26;480(8):521-37© 2023 The Author(s). This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY-NC-ND).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/573222026-06-12T07:21:37Z
dc.title.none.fl_str_mv The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development
title The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development
spellingShingle The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development
Mattimoe, Tom
X chromosome
Dosage compensation
Epigenetic reprogramming
Germ cell development
title_short The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development
title_full The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development
title_fullStr The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development
title_full_unstemmed The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development
title_sort The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development
dc.creator.none.fl_str_mv Mattimoe, Tom
Payer, Bernhard
author Mattimoe, Tom
author_facet Mattimoe, Tom
Payer, Bernhard
author_role author
author2 Payer, Bernhard
author2_role author
dc.subject.none.fl_str_mv X chromosome
Dosage compensation
Epigenetic reprogramming
Germ cell development
topic X chromosome
Dosage compensation
Epigenetic reprogramming
Germ cell development
description In female mammals, the two X chromosomes are subject to epigenetic gene regulation in order to balance X-linked gene dosage with autosomes and in relation to males, which have one X and one Y chromosome. This is achieved by an intricate interplay of several processes; X-chromosome inactivation and reactivation elicit global epigenetic regulation of expression from one X chromosome in a stage-specific manner, whilst the process of X-chromosome upregulation responds to this by fine-tuning transcription levels of the second X. The germline is unique in its function of transmitting both the genetic and epigenetic information from one generation to the next, and remodelling of the X chromosome is one of the key steps in setting the stage for successful development. Here, we provide an overview of the complex dynamics of X-chromosome dosage control during embryonic and germ cell development, and aim to decipher its potential role for normal germline competency.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/57322
http://dx.doi.org/10.1042/BCJ20220450
url http://hdl.handle.net/10230/57322
http://dx.doi.org/10.1042/BCJ20220450
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Biochem J. 2023 Apr 26;480(8):521-37
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Portland Press
publisher.none.fl_str_mv Portland Press
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419445655437313
score 15,811543

Registros relacionados