Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism.

BACKGROUND AND OBJECTIVES: There is adherence to a healthy Mediterranean diet (MedDiet), but adherence varies widely. Precision nutrition is increasingly interested in individual characteristics influencing diet adherence, but few studies have examined personality traits. Our main aim was to investi...

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Autores: Sorlí JV, Ortega-Azorín C, Coltell O, Fernández-Carrión R, Asensio EM, Portolés O, Perez-Fidalgo A, Ramirez-Sabio JB, Guillem-Saiz J, Costa JA, Gimenez-Alba IM, Barragán R, Ordovas JM, Corella D
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p20568
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/20568
Access Level:acceso abierto
Palabra clave:Mediterranean diet
gene-diet interactions
genetics
neuroticism
personality traits
precision nutrition
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spelling Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism.Sorlí JVOrtega-Azorín CColtell OFernández-Carrión RAsensio EMPortolés OPerez-Fidalgo ARamirez-Sabio JBGuillem-Saiz JCosta JAGimenez-Alba IMBarragán ROrdovas JMCorella DMediterranean dietgene-diet interactionsgeneticsneuroticismpersonality traitsprecision nutritionBACKGROUND AND OBJECTIVES: There is adherence to a healthy Mediterranean diet (MedDiet), but adherence varies widely. Precision nutrition is increasingly interested in individual characteristics influencing diet adherence, but few studies have examined personality traits. Our main aim was to investigate the association between personality traits and MedDiet adherence. Our secondary aims were to explore genome-wide genetic variants associated with neuroticism, including replication of previous findings, as well as to explore gene-MedDiet interactions. METHODS: We analyzed participants (aged 55-75) in the PREDIMED-Plus-Valencia study and measured clinical, lifestyle, and genetic factors. The Eysenck Personality Questionnaire-Revised (EPQ-R) was used to measure neuroticism, psychoticism, and extraversion. Genotyping was undertaken, and associations with candidate SNPs, genome-wide association studies (GWAS), genetic risk scores (GRS), and gene-MedDiet interactions were explored. RESULTS: Neuroticism was inversely (beta = -0.09; p = 0.001) associated with adherence to the Mediterranean diet (MEDAS-17). Likewise, the probability of low MedDiet adherence increased neuroticism (OR: 1.27; 95% CI: 1.02-1.60; p = 0.031 per SD). In the GWAS for this trait, several SNPs surpassed the suggestive level of statistical significance. The most strongly associated was rs10181407-NDUFA10 (NADH dehydrogenase 1 alpha subcomplex subunit 10) (beta = -2.39; p = 2.70 × 10(-6)). The GRS for neuroticism was significantly associated with MedDiet adherence (beta = -0.18; p = 0.020), increasing the causality level. We replicated some candidate SNPs, and among them, the rs2243873-EHMT2 (euchromatic histone lysine methyltransferase 2) gene. The analysis of gene-MedDiet interactions revealed the role of these dietary modulations. CONCLUSIONS: Neuroticism was the personality trait most inversely associated with MedDiet adherence, suggesting its integration in precision nutrition analysis. Moreover, neuroticism-related genetics and MedDiet modulations will also be important.MDPI2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/20568NutrientsISSN: 20726643reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p205682026-06-07T16:35:31Z
dc.title.none.fl_str_mv Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism.
title Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism.
spellingShingle Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism.
Sorlí JV
Mediterranean diet
gene-diet interactions
genetics
neuroticism
personality traits
precision nutrition
title_short Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism.
title_full Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism.
title_fullStr Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism.
title_full_unstemmed Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism.
title_sort Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism.
dc.creator.none.fl_str_mv Sorlí JV
Ortega-Azorín C
Coltell O
Fernández-Carrión R
Asensio EM
Portolés O
Perez-Fidalgo A
Ramirez-Sabio JB
Guillem-Saiz J
Costa JA
Gimenez-Alba IM
Barragán R
Ordovas JM
Corella D
author Sorlí JV
author_facet Sorlí JV
Ortega-Azorín C
Coltell O
Fernández-Carrión R
Asensio EM
Portolés O
Perez-Fidalgo A
Ramirez-Sabio JB
Guillem-Saiz J
Costa JA
Gimenez-Alba IM
Barragán R
Ordovas JM
Corella D
author_role author
author2 Ortega-Azorín C
Coltell O
Fernández-Carrión R
Asensio EM
Portolés O
Perez-Fidalgo A
Ramirez-Sabio JB
Guillem-Saiz J
Costa JA
Gimenez-Alba IM
Barragán R
Ordovas JM
Corella D
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mediterranean diet
gene-diet interactions
genetics
neuroticism
personality traits
precision nutrition
topic Mediterranean diet
gene-diet interactions
genetics
neuroticism
personality traits
precision nutrition
description BACKGROUND AND OBJECTIVES: There is adherence to a healthy Mediterranean diet (MedDiet), but adherence varies widely. Precision nutrition is increasingly interested in individual characteristics influencing diet adherence, but few studies have examined personality traits. Our main aim was to investigate the association between personality traits and MedDiet adherence. Our secondary aims were to explore genome-wide genetic variants associated with neuroticism, including replication of previous findings, as well as to explore gene-MedDiet interactions. METHODS: We analyzed participants (aged 55-75) in the PREDIMED-Plus-Valencia study and measured clinical, lifestyle, and genetic factors. The Eysenck Personality Questionnaire-Revised (EPQ-R) was used to measure neuroticism, psychoticism, and extraversion. Genotyping was undertaken, and associations with candidate SNPs, genome-wide association studies (GWAS), genetic risk scores (GRS), and gene-MedDiet interactions were explored. RESULTS: Neuroticism was inversely (beta = -0.09; p = 0.001) associated with adherence to the Mediterranean diet (MEDAS-17). Likewise, the probability of low MedDiet adherence increased neuroticism (OR: 1.27; 95% CI: 1.02-1.60; p = 0.031 per SD). In the GWAS for this trait, several SNPs surpassed the suggestive level of statistical significance. The most strongly associated was rs10181407-NDUFA10 (NADH dehydrogenase 1 alpha subcomplex subunit 10) (beta = -2.39; p = 2.70 × 10(-6)). The GRS for neuroticism was significantly associated with MedDiet adherence (beta = -0.18; p = 0.020), increasing the causality level. We replicated some candidate SNPs, and among them, the rs2243873-EHMT2 (euchromatic histone lysine methyltransferase 2) gene. The analysis of gene-MedDiet interactions revealed the role of these dietary modulations. CONCLUSIONS: Neuroticism was the personality trait most inversely associated with MedDiet adherence, suggesting its integration in precision nutrition analysis. Moreover, neuroticism-related genetics and MedDiet modulations will also be important.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/20568
url https://incliva.portalinvestigacion.com/publicaciones/20568
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Nutrients
ISSN: 20726643
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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