A longitudinal study of free leptin index in pre-eclamptic pregnancies

The ratio between circulating levels of leptin and soluble leptin receptor (sOB-R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild pre-eclamptic pregnancies in a nested case-control study within a prospective...

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Detalles Bibliográficos
Autores: Garcés, M.F., Buell-Acosta, J.D., Rodríguez-Navarro, H.A., Páez-Leal, M.C., Maldonado-Acosta, L.M., Peralta-Franco, J.J., Burgos-Cardenas, Á.J., Ángel-Müller, E., Parada-Baños, A.J., Parra-Pineda, M.O., Eslava-Schmalbach, J., Escobar-Sarmiento, C.A., Lacunza, E., Caminos-Cepeda, S.A., Castaño, J.P., Nogueiras Pozo, Rubén, Diéguez González, Carlos, Ruiz-Parra, A.I., Caminos, J.E.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/20982
Acceso en línea:https://portalcientifico.sergas.gal//documentos/642b37c2a1c8a315fd233e44
http://hdl.handle.net/20.500.11940/20982
Access Level:acceso abierto
Palabra clave:Pregnancy
Female
Humans
Leptin
Pre-Eclampsia
Longitudinal Studies
Case-Control Studies
Pregnancy Trimester, Third
Receptors, Leptin
AS Santiago
IDIS
Descripción
Sumario:The ratio between circulating levels of leptin and soluble leptin receptor (sOB-R), the free leptin index (FLI), is used as a marker of leptin resistance. Therefore, the aim of our study was to investigate the FLI in mild pre-eclamptic pregnancies in a nested case-control study within a prospective observational study. Circulating levels of leptin and sOB-R levels rise significantly during pregnancy in healthy (p < 0.05) (n = 46) and pre-eclamptic pregnancies (p < 0.05) (n = 20). Serum levels of leptin were significantly higher in pre-eclamptic compared to healthy pregnancies at second and third trimesters of pregnancy (p < 0.05). Additionally, serum levels of sOB-R were significantly lower in pre-eclamptic pregnancies during the second and third trimesters of pregnancy compared to healthy pregnancies (p < 0.05). Moreover, we found that FLI did not vary significantly during pregnancy in healthy women (p > 0.05), while it increases in pre-eclamptic pregnancies (p < 0.05). Indeed, FLI was significantly higher at second and third trimesters of pregnancy in pre-eclamptic compared to healthy pregnancies (p < 0.05). In addition, FLI was significantly higher in the luteal phase compared with the follicular phase of the menstrual cycle in eumenorrheic women (p < 0.05). Receiver operating characteristic (ROC) curve analysis revealed the ability of leptin (AUC = 0.72) and FLI (AUC = 0.67) as a reliable predictor for mild pre-eclampsia during the second trimester of pregnancy. In conclusion, our findings show that FLI were significantly increased in mild pre-eclamptic pregnancies and allowed us to hypothesize that this rise might alter leptin bioavailability and bioactivity which might lead to the sympathetic hyperactivity and the hypertensive disorders during pregnancy.

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