Serotonin Modulation of Prefronto-Hippocampal Rhythms in Health and Disease

There is mounting evidence that most cognitive functions depend upon the coordinated activity of neuronal networks often located far from each other in the brain. Ensembles of neurons synchronize their activity, generating oscillations at different frequencies that may encode behavior by allowing an...

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Authors: Puig Velasco, María Victoria, Gener, Thomas
Format: article
Status:Versión aceptada para publicación
Publication Date:2015
Country:España
Institution:Universitat Pompeu Fabra
Repository:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/24619
Online Access:http://hdl.handle.net/10230/24619
http://dx.doi.org/10.1021/cn500350e
Access Level:Open access
Keyword:Serotonina
Hipocamp (Cervell)
Depressió psíquica
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oai_identifier_str oai:repositori.upf.edu:10230/24619
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spelling Serotonin Modulation of Prefronto-Hippocampal Rhythms in Health and DiseasePuig Velasco, María VictoriaGener, ThomasSerotoninaHipocamp (Cervell)Depressió psíquicaThere is mounting evidence that most cognitive functions depend upon the coordinated activity of neuronal networks often located far from each other in the brain. Ensembles of neurons synchronize their activity, generating oscillations at different frequencies that may encode behavior by allowing an efficient communication between brain areas. The serotonin system, by virtue of the widespread arborisation of serotonergic neurons, is in an excellent position to exert strong modulatory actions on brain rhythms. These include specific oscillatory activities in the prefrontal cortex and the hippocampus, two brain areas essential for many higher-order cognitive functions. Psychiatric patients show abnormal oscillatory activities in these areas, notably patients with schizophrenia who display psychotic symptoms as well as affective and cognitive impairments. Synchronization of neural activity between the prefrontal cortex and the hippocampus seems to be important for cognition and, in fact, reduced prefronto-hippocampal synchrony has been observed in a genetic mouse model of schizophrenia. Here, we review recent advances in the field of neuromodulation of brain rhythms by serotonin, focusing on the actions of serotonin in the prefrontal cortex and the hippocampus. Considering that the serotonergic system plays a crucial role in cognition and mood and is a target of many psychiatric treatments, it is surprising that this field of research is still in its infancy. In that regard, we point to future investigations that are much needed in this field.MV Puig is recipient of a Ramón y Cajal awardfrom the Spanish Ministry of Economyand Competitiveness (MICINN) (RyC-2012-10042) and a 2013 NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation.American Chemical Society201520162015info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/24619http://dx.doi.org/10.1021/cn500350ereponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésACS Chemical Neuroscience. 2015 Jul 15;6(7):1017-25info:eu-repo/grantAgreement/ES/3PN/RYC2012-10042This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Chemical Neuroscience , copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/cn500350e.info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/246192026-06-12T07:21:37Z
dc.title.none.fl_str_mv Serotonin Modulation of Prefronto-Hippocampal Rhythms in Health and Disease
title Serotonin Modulation of Prefronto-Hippocampal Rhythms in Health and Disease
spellingShingle Serotonin Modulation of Prefronto-Hippocampal Rhythms in Health and Disease
Puig Velasco, María Victoria
Serotonina
Hipocamp (Cervell)
Depressió psíquica
title_short Serotonin Modulation of Prefronto-Hippocampal Rhythms in Health and Disease
title_full Serotonin Modulation of Prefronto-Hippocampal Rhythms in Health and Disease
title_fullStr Serotonin Modulation of Prefronto-Hippocampal Rhythms in Health and Disease
title_full_unstemmed Serotonin Modulation of Prefronto-Hippocampal Rhythms in Health and Disease
title_sort Serotonin Modulation of Prefronto-Hippocampal Rhythms in Health and Disease
dc.creator.none.fl_str_mv Puig Velasco, María Victoria
Gener, Thomas
author Puig Velasco, María Victoria
author_facet Puig Velasco, María Victoria
Gener, Thomas
author_role author
author2 Gener, Thomas
author2_role author
dc.subject.none.fl_str_mv Serotonina
Hipocamp (Cervell)
Depressió psíquica
topic Serotonina
Hipocamp (Cervell)
Depressió psíquica
description There is mounting evidence that most cognitive functions depend upon the coordinated activity of neuronal networks often located far from each other in the brain. Ensembles of neurons synchronize their activity, generating oscillations at different frequencies that may encode behavior by allowing an efficient communication between brain areas. The serotonin system, by virtue of the widespread arborisation of serotonergic neurons, is in an excellent position to exert strong modulatory actions on brain rhythms. These include specific oscillatory activities in the prefrontal cortex and the hippocampus, two brain areas essential for many higher-order cognitive functions. Psychiatric patients show abnormal oscillatory activities in these areas, notably patients with schizophrenia who display psychotic symptoms as well as affective and cognitive impairments. Synchronization of neural activity between the prefrontal cortex and the hippocampus seems to be important for cognition and, in fact, reduced prefronto-hippocampal synchrony has been observed in a genetic mouse model of schizophrenia. Here, we review recent advances in the field of neuromodulation of brain rhythms by serotonin, focusing on the actions of serotonin in the prefrontal cortex and the hippocampus. Considering that the serotonergic system plays a crucial role in cognition and mood and is a target of many psychiatric treatments, it is surprising that this field of research is still in its infancy. In that regard, we point to future investigations that are much needed in this field.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/24619
http://dx.doi.org/10.1021/cn500350e
url http://hdl.handle.net/10230/24619
http://dx.doi.org/10.1021/cn500350e
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv ACS Chemical Neuroscience. 2015 Jul 15;6(7):1017-25
info:eu-repo/grantAgreement/ES/3PN/RYC2012-10042
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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