New Perspective on Planar Inductive Sensors: Radio-Frequency Refractometry for Highly Sensitive Quantification of Magnetic Nanoparticles

We demonstrate how resonant planar coils may be used as sensors to detect and quantify magnetic nanoparticles reliably. A coil’s resonant frequency depends on the adjacent materials’ magnetic permeability and electric permittivity. A small number of nanoparticles dispersed on a supporting matrix on...

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Detalles Bibliográficos
Autores: Marqués Fernández, José Luis, Salvador, María, Martínez García, José Carlos, Fernández Miaja, Pablo, García Arribas, Alfredo, Rivas, Montserrat
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/60338
Acceso en línea:http://hdl.handle.net/10810/60338
Access Level:acceso abierto
Palabra clave:self-resonant frequency
inductive sensor
coil
nanoparticles
magnetic nanoparticles
magnetic lateral flow immunoassays
impedance
refraction index
magnetic permeability
electric permittivity
Descripción
Sumario:We demonstrate how resonant planar coils may be used as sensors to detect and quantify magnetic nanoparticles reliably. A coil’s resonant frequency depends on the adjacent materials’ magnetic permeability and electric permittivity. A small number of nanoparticles dispersed on a supporting matrix on top of a planar coil circuit may thus be quantified. Such nanoparticle detection has application detection to create new devices to assess biomedicine, food quality assurance, and environmental control challenges. We developed a mathematical model for the inductive sensor response at radio frequencies to obtain the nanoparticles’ mass from the self-resonance frequency of the coil. In the model, the calibration parameters only depend on the refraction index of the material around the coil, not on the separate magnetic permeability and electric permittivity. The model compares favourably with three-dimensional electromagnetic simulations and independent experimental measurements. The sensor can be scaled and automated in portable devices to measure small quantities of nanoparticles at a low cost. The resonant sensor combined with the mathematical model is a significant improvement over simple inductive sensors, which operate at smaller frequencies and do not have the required sensitivity, and oscillator-based inductive sensors, which focus on just magnetic permeability.