Host virus and pneumococcus-specific immune responses in high-count monoclonal B-cell lymphocytosis and chronic lymphocytic leukemia: implications for disease progression

[EN]Patients diagnosed with chronic lymphocytic leukemia (CLL) display a high incidence of infections due to an associated immunodeficiency that includes hypogammaglobulinemia. A higher risk of infections has also been recently reported for high-count monoclonal B-cell lymphocytosis, while no inform...

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Detalles Bibliográficos
Autores: Criado García, Ignacio, Muñoz Criado, Santiago, Rodríguez Caballero, María Arantzazu, Nieto Pérez, Wendy Grey, Romero, Alfonso, Fernández Navarro, Paulino, Alcoceba Sánchez, Miguel, Contreras, Teresa, González Díaz, Marcos, Orfao de Matos Correia e Vale, José Alberto, Almeida Parra, Julia María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/146416
Acceso en línea:http://hdl.handle.net/10366/146416
Access Level:acceso abierto
Palabra clave:Host Virus
Pneumococcus
Monoclonal B-cell
Lymphocytosis
Chronic lymphocytic leukemia
Disease
Pneumococcal Infections
Leukemia, Lymphocytic, Chronic, B-Cell
Antibodies, Monoclonal
3205.04 Hematología
anticuerpos monoclonales
infecciones neumocócicas
leucemia linfocítica crónica de células B
linfocitosis
Descripción
Sumario:[EN]Patients diagnosed with chronic lymphocytic leukemia (CLL) display a high incidence of infections due to an associated immunodeficiency that includes hypogammaglobulinemia. A higher risk of infections has also been recently reported for high-count monoclonal B-cell lymphocytosis, while no information is available in low-count monoclonal B-cell lymphocytosis. Here, we evaluated the status of the humoral immune system in patients with chronic lymphocytic leukemia (n=58), as well as in low- (n=71) and high- (n=29) count monoclonal B-cell lymphocytosis versus healthy donors (n=91). Total free plasma immunoglobulin titers and specific levels of antibodies against cytomegalovirus, Epstein-Barr virus, influenza and S.pneumoniae were measured by nephelometry and ELISA-based techniques, respectively. Overall, our results show that both CLL and high-count monoclonal B-cell lymphocytosis patients, but not low-count monoclonal B-cell lymphocytosis subjects, present with relatively high levels of antibodies specific for the latent viruses investigated, associated with progressively lower levels of S.pneumoniae-specific immunoglobulins.

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