Reelin sets the pace of neocortical neurogenesis

12 p., 7 figures and references.

Detalles Bibliográficos
Autores: Lakomá, Jarmila, García-Alonso, Luis, Luque, Juan M.
Tipo de recurso: artículo
Fecha de publicación:2011
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/55069
Acceso en línea:http://hdl.handle.net/10261/55069
Access Level:acceso abierto
Palabra clave:Cortex development
Mouse
Notch
Radial glia
Reelin
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spelling Reelin sets the pace of neocortical neurogenesisLakomá, JarmilaGarcía-Alonso, LuisLuque, Juan M.Cortex developmentMouseNotchRadial gliaReelin12 p., 7 figures and references.Migration of neurons during cortical development is often assumed to rely on purely post-proliferative reelin signaling. However, Notch signaling, long known to regulate neural precursor formation and maintenance, is required for the effects of reelin on neuronal migration. Here, we show that reelin gain-of-function causes a higher expression of Notch target genes in radial glia and accelerates the production of both neurons and intermediate progenitor cells. Converse alterations correlate with reelin lossof-function, consistent with reelin controlling Notch signaling during neurogenesis. Ectopic expression of reelin in isolated clones of progenitors causes a severe reduction in neuronal differentiation. In mosaic cell cultures, reelin-primed progenitor cells respond to wild-type cells by further decreasing neuronal differentiation, consistent with an increased sensitivity to lateral inhibition. These results indicate that reelin and Notch signaling cooperate to set the pace of neocortical neurogenesis, a prerequisite for proper neuronal migration and cortical layering.This work was supported in part by grants from the Generalitat Valenciana-Prometeo [2008-134 to L.G.-A.]; the Spanish Ministry of Science and Innovation [SAF2004-07685 to J.M.L.]; and the Fundación Médica Mutua Madrileña [to J.M.L.]. J.L. holds a Junta para la Ampliación de Estudios (JAE) Programme/Spanish National Research Council (CSIC) pre-doctoral fellowship.Peer reviewedCompany of Biologists201220122011info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501http://hdl.handle.net/10261/55069reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1242/dev.063776info:eu-repo/semantics/openAccessoai:digital.csic.es:10261/550692026-05-22T06:33:51Z
dc.title.none.fl_str_mv Reelin sets the pace of neocortical neurogenesis
title Reelin sets the pace of neocortical neurogenesis
spellingShingle Reelin sets the pace of neocortical neurogenesis
Lakomá, Jarmila
Cortex development
Mouse
Notch
Radial glia
Reelin
title_short Reelin sets the pace of neocortical neurogenesis
title_full Reelin sets the pace of neocortical neurogenesis
title_fullStr Reelin sets the pace of neocortical neurogenesis
title_full_unstemmed Reelin sets the pace of neocortical neurogenesis
title_sort Reelin sets the pace of neocortical neurogenesis
dc.creator.none.fl_str_mv Lakomá, Jarmila
García-Alonso, Luis
Luque, Juan M.
author Lakomá, Jarmila
author_facet Lakomá, Jarmila
García-Alonso, Luis
Luque, Juan M.
author_role author
author2 García-Alonso, Luis
Luque, Juan M.
author2_role author
author
dc.subject.none.fl_str_mv Cortex development
Mouse
Notch
Radial glia
Reelin
topic Cortex development
Mouse
Notch
Radial glia
Reelin
description 12 p., 7 figures and references.
publishDate 2011
dc.date.none.fl_str_mv 2011
2012
2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/55069
url http://hdl.handle.net/10261/55069
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1242/dev.063776
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Company of Biologists
publisher.none.fl_str_mv Company of Biologists
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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