GHRH and the prostate

In the late 1960s and early 1970s, hypothalamic regulatory hormones were isolated, characterized and sequenced. Later, it was demonstrated hypothalamic and ectopic production of growth hormone-releasing hormone (GHRH) in normal and tumor tissues, of both humans and animals. Pituitary-type GHRH recep...

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Autores: Muñoz Moreno, Laura|||0000-0002-2322-8986, Román Curto, Irene de los Dolores|||0000-0002-4897-1549, Bajo Chueca, Ana María|||0000-0002-4944-4222
Tipo de documento: artigo
Data de publicação:2024
País:España
Recursos:Universidad de Alcalá (UAH)
Repositório:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglês
OAI Identifier:oai:ebuah.uah.es:10017/63307
Acesso em linha:http://hdl.handle.net/10017/63307
https://dx.doi.org/10.1007/s11154-024-09922-9
Access Level:Acceso aberto
Palavra-chave:GHRH
GHRH-R
GHRH-R antagonists
Prostate
SVs
pGHRH-R
Medicina
Medicine
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spelling GHRH and the prostateMuñoz Moreno, Laura|||0000-0002-2322-8986Román Curto, Irene de los Dolores|||0000-0002-4897-1549Bajo Chueca, Ana María|||0000-0002-4944-4222GHRHGHRH-RGHRH-R antagonistsProstateSVspGHRH-RMedicinaMedicineIn the late 1960s and early 1970s, hypothalamic regulatory hormones were isolated, characterized and sequenced. Later, it was demonstrated hypothalamic and ectopic production of growth hormone-releasing hormone (GHRH) in normal and tumor tissues, of both humans and animals. Pituitary-type GHRH receptors (pGHRH-R) had been demonstrated to be expressed predominantly in the anterior pituitary gland but also found in other somatic cells, and significantly present in various human cancers; in addition, the expression of splice variants (SVs) of GHRH receptor (GHRH-R) has been found not only in the pituitary but in extrapituitary tissues, including human neoplasms. In relation to the prostate, besides the pGHRH-R, it has been detected the presence of truncated splice variants of GHRH-R (SV1-SV4) in normal human prostate and human prostate cancer (PCa) specimens; lastly, a novel SV of GHRH-R has been detected in human PCa. Signaling pathways activated by GHRH include AC/cAMP/PKA, Ras/Raf/ERK, PI3K/Akt/mTOR and JAK2/STAT3, which are involved in processes such as cell survival, proliferation and cytokine secretion. The neuropeptide GHRH can also transactivate the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER)-2. Thus, GHRH-Rs have become drug targets for several types of clinical conditions, including prostate-related conditions such as prostatitis, benign hyperplasia and cancer. Over the last fifty years, the development of GHRH-R receptor antagonists has been unstoppable, improving their potency, stability and affinity for the receptor. The last series of GHRH-R antagonists, AVR, exhibits superior anticancer and anti-inflammatory activities in both in vivo and in vitro assays.Fundación para la Investigación Biomédica Hospital Universitario Príncipe de AsturiasJunta de Comunidades de Castilla-La ManchaUniversidad de Alcalá20242024-11-07journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/63307https://dx.doi.org/10.1007/s11154-024-09922-9reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengUAH Not available CCG2014%2FBIO-028UAH Not available CCG2015%2FBIO-010UAH Not available CCG2016%2FBIO024HUPA Not available FIBPI13-04open accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/633072026-06-18T11:13:07Z
dc.title.none.fl_str_mv GHRH and the prostate
title GHRH and the prostate
spellingShingle GHRH and the prostate
Muñoz Moreno, Laura|||0000-0002-2322-8986
GHRH
GHRH-R
GHRH-R antagonists
Prostate
SVs
pGHRH-R
Medicina
Medicine
title_short GHRH and the prostate
title_full GHRH and the prostate
title_fullStr GHRH and the prostate
title_full_unstemmed GHRH and the prostate
title_sort GHRH and the prostate
dc.creator.none.fl_str_mv Muñoz Moreno, Laura|||0000-0002-2322-8986
Román Curto, Irene de los Dolores|||0000-0002-4897-1549
Bajo Chueca, Ana María|||0000-0002-4944-4222
author Muñoz Moreno, Laura|||0000-0002-2322-8986
author_facet Muñoz Moreno, Laura|||0000-0002-2322-8986
Román Curto, Irene de los Dolores|||0000-0002-4897-1549
Bajo Chueca, Ana María|||0000-0002-4944-4222
author_role author
author2 Román Curto, Irene de los Dolores|||0000-0002-4897-1549
Bajo Chueca, Ana María|||0000-0002-4944-4222
author2_role author
author
dc.subject.none.fl_str_mv GHRH
GHRH-R
GHRH-R antagonists
Prostate
SVs
pGHRH-R
Medicina
Medicine
topic GHRH
GHRH-R
GHRH-R antagonists
Prostate
SVs
pGHRH-R
Medicina
Medicine
description In the late 1960s and early 1970s, hypothalamic regulatory hormones were isolated, characterized and sequenced. Later, it was demonstrated hypothalamic and ectopic production of growth hormone-releasing hormone (GHRH) in normal and tumor tissues, of both humans and animals. Pituitary-type GHRH receptors (pGHRH-R) had been demonstrated to be expressed predominantly in the anterior pituitary gland but also found in other somatic cells, and significantly present in various human cancers; in addition, the expression of splice variants (SVs) of GHRH receptor (GHRH-R) has been found not only in the pituitary but in extrapituitary tissues, including human neoplasms. In relation to the prostate, besides the pGHRH-R, it has been detected the presence of truncated splice variants of GHRH-R (SV1-SV4) in normal human prostate and human prostate cancer (PCa) specimens; lastly, a novel SV of GHRH-R has been detected in human PCa. Signaling pathways activated by GHRH include AC/cAMP/PKA, Ras/Raf/ERK, PI3K/Akt/mTOR and JAK2/STAT3, which are involved in processes such as cell survival, proliferation and cytokine secretion. The neuropeptide GHRH can also transactivate the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER)-2. Thus, GHRH-Rs have become drug targets for several types of clinical conditions, including prostate-related conditions such as prostatitis, benign hyperplasia and cancer. Over the last fifty years, the development of GHRH-R receptor antagonists has been unstoppable, improving their potency, stability and affinity for the receptor. The last series of GHRH-R antagonists, AVR, exhibits superior anticancer and anti-inflammatory activities in both in vivo and in vitro assays.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024-11-07
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/63307
https://dx.doi.org/10.1007/s11154-024-09922-9
url http://hdl.handle.net/10017/63307
https://dx.doi.org/10.1007/s11154-024-09922-9
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv UAH Not available CCG2014%2FBIO-028
UAH Not available CCG2015%2FBIO-010
UAH Not available CCG2016%2FBIO024
HUPA Not available FIBPI13-04
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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