Improving pre-operative binary grading: relevance of p53 and PR expression in grade 2 endometrioid endometrial carcinoma

Objective: This study aimed to evaluate the association between pre-operative progesterone receptor (PR) and p53 expression and prognosis in pre-operative grade 2 endometrioid endometrial carcinoma compared with grade 1 and grade 3 carcinomas. Methods: Three European endometrial carcinoma cohort stu...

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Detalles Bibliográficos
Autores: Meijs-Hermanns, Puk, Werner, Henrica M.J., Kooreman, Loes, Bretová, Petra, Weinberger, Vit, Vrede, Stephanie W., Alcala, Luthy S.M., Amant, Frederic, Asberger, Jasmin, Bednaříková, Markéta, Boll, Dorry, Bronkhorst, Carolien M., Bulten, Johan, Gil-Moreno, Antonio, Haldorsen, Ingfrid S., Hausnerová, Jitka, Huvila, Jutta, Koskas, Martin, Krakstad, Camilla, Küsters-Vandevelde, Heidi V. N, Mancebo, Gemma, Matias-Guiu, Xavier, Ngo, Huy, Pijlman, Brenda M., Santacana Espasa, Maria, Smink, Marieke, Trovik, Jone, Verhoef, Viola M.J., Van de Vijver, Koen, van Hamont, Dennis, van der Wurff, Anneke A. M., Pijnenborg, Johanna M. A., Visser, Nicole C.M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/468043
Acceso en línea:https://doi.org/10.1016/j.ijgc.2025.101682
https://hdl.handle.net/10459.1/468043
Access Level:acceso abierto
Palabra clave:Endometrioid Endometrial Carcinoma
Grade 2
Progesterone Receptor
p53
Descripción
Sumario:Objective: This study aimed to evaluate the association between pre-operative progesterone receptor (PR) and p53 expression and prognosis in pre-operative grade 2 endometrioid endometrial carcinoma compared with grade 1 and grade 3 carcinomas. Methods: Three European endometrial carcinoma cohort studies were included. Patients with pre-operative grade 2 endometrioid carcinoma and known pre-operative PR and p53 status were included (n = 400), as were patients with pre-operative grade 1 (n = 602) or grade 3 (n = 148) endometrioid carcinomas. Kaplan-Meier and Cox regression analyses were performed to analyze disease-specific and disease-free survival. Results: Patients with pre-operative grade 2 endometrial carcinoma and wild-type p53 plus PR-positive expression showed a similar 7-year disease-specific survival to grade 1 endometrial carcinoma patients (95.8% vs 97.5%, p = .13), while the 7-year disease-specific survival of patients with grade 2 endometrial carcinoma with p53 aberrant and/or negative PR expression (83.5%) was significantly lower (p < .001). The combination of these markers was an independent prognostic factor in multivariate Cox regression analyses. Conclusions: The prognostic impact of pre-operative p53 and PR expression in patients with grade 2 endometrioid endometrial carcinoma supports a modified binary grading system in which grade 2 patients should be pre-operatively classified as low- or high-grade depending on p53 and PR expression.

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