Dopamine DRD2/ANKK1 Taq1A and DAT1 VNTR polymorphisms are associated with a cognitive flexibility profile in pathological gamblers

Like drug addiction, pathological gambling (PG) has been associated with impairments in executive functions and alterations in dopaminergic functioning; however, the role of dopamine (DA) in the executive profile of PG remains unclear. The aim of this study was to identify whether the DRD2/ANKK1 Taq...

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Detalles Bibliográficos
Autores: Fagundo, Ana Beatriz|||0000-0003-1703-9457, Fernández Aranda, Fernando|||0000-0002-2968-9898, Torre, Rafael de la|||0000-0002-6765-1866, Verdejo-Garcia, Antonio|||0000-0001-8874-9339, Granero, Roser|||0000-0001-6308-3198, Penelo Werner, Eva|||0000-0001-6796-7660, Gené Badia, Manel, Barrot, Carme|||0000-0002-3141-4092, Sánchez, Cristina, Alvarez Moya, Eva Maria|||0000-0002-3723-3225, Ochoa, Cristian|||0000-0002-4508-0951, Aymamí, Neus|||0000-0002-4607-9565, Gomez-Peña, Monica|||0000-0001-6194-8266, Menchón Magriñá, José Manuel|||0000-0002-6231-6524, Jiménez Murcia, Susana|||0000-0002-3596-8033
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:319688
Acceso en línea:https://ddd.uab.cat/record/319688
https://dx.doi.org/urn:doi:10.1177/0269881114551079
Access Level:acceso abierto
Palabra clave:Addiction
Cognition
Cognitive flexibility
Dopamine
Dopamine receptor
Dopamine transport
Executive functions
Gambling
Genetics
Inhibition response
Pathological gambling
Polymorphism
Descripción
Sumario:Like drug addiction, pathological gambling (PG) has been associated with impairments in executive functions and alterations in dopaminergic functioning; however, the role of dopamine (DA) in the executive profile of PG remains unclear. The aim of this study was to identify whether the DRD2/ANKK1 Taq1Ars1800497 and the DAT1-40 bp VNTR polymorphisms are associated with cognitive flexibility (measured by Wisconsin Card Sorting Test (WCST) and Trail Making Test (TMT)) and inhibition response (measured by Stroop Color and Word Test (SCWT)), in a clinical sample of 69 PG patients. Our results showed an association between DA functioning and cognitive flexibility performance. The Taq1A A1+ (A1A2/A1A1) genotype was associated with poorer TMT performance (p < 0.05), while DAT1 9-repeat homozygotes displayed better WCST performance (p < 0.05) than either 10-repeat homozygotes or heterozygotes. We did not find any association between the DRD2 or DAT1 polymorphisms and the inhibition response. These results suggested that pathological gamblers with genetic predispositions toward lower availability of DA and D2 receptor density are at a higher risk of cognitive flexibility difficulties. Future studies should aim to shed more light on the genetic mechanisms underlying the executive profile in PG.

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