Microwave-Assisted Selective and Efficient Synthesis of 1,3,5-Triazinyl Mono and Bisureas

An efficient and sustainable microwave-assisted approach for the one-step preparation of a wide range of 1,3,5-triazinyl mono- and bisureas has been developed, combining solvent-free conditions and microwave irradiation. In these conditions the very unreactive amino groups of 1,3,5-triazine-2,4-diam...

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Detalhes bibliográficos
Autores: Hoz Ayuso, Antonio de la, Ruiz Carretero, Amparo, Ramírez, José Ramón, Sánchez Migallón, Ana
Formato: artículo
Fecha de publicación:2014
País:España
Recursos:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/38671
Acesso em linha:https://hdl.handle.net/10578/38671
Access Level:acceso embargado
Palavra-chave:Microwave, Triazine, Green chemistry, Ureas, Hydrogen bonds
Descrição
Resumo:An efficient and sustainable microwave-assisted approach for the one-step preparation of a wide range of 1,3,5-triazinyl mono- and bisureas has been developed, combining solvent-free conditions and microwave irradiation. In these conditions the very unreactive amino groups of 1,3,5-triazine-2,4-diamines successfully react with phenylisocyanate to yield selectively mono and bisureas. This protocol resulted in the shortest reaction times reported so far and is generally applicable for the preparation of these valuable heterocyclic systems.