Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population study

Introduction: Measuring soluble interleukin-2 receptor (sIL-2R) might be useful for diagnosis and monitoring of immune-mediated diseases. The study investigated factors associated with serum sIL-2R concentrations in adults. Methods: Serum sIL-2R concentrations were measured in 1499 randomly selected...

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Autores: Alende-Castro, V., Alonso Sampedro, Manuela, Fernández Merino, María del Carmen, Sopeña Perez-Argüelles, Bernardo, Vidal, C., Gude Sampedro, Francisco, González Quintela, Arturo
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Servizo Galego de Saúde (SERGAS)
Repositorio:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/21499
Acceso en línea:https://portalcientifico.sergas.gal//documentos/64046e82d5b0fa1e7b277182
http://hdl.handle.net/20.500.11940/21499
Access Level:acceso abierto
Palabra clave:AS Santiago
IDIS
AS Santiago AP
CHUS
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spelling Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population studyAlende-Castro, V.Alonso Sampedro, ManuelaFernández Merino, María del CarmenSopeña Perez-Argüelles, BernardoVidal, C.Gude Sampedro, FranciscoGonzález Quintela, ArturoAS SantiagoIDISAS SantiagoAS Santiago APAS SantiagoCHUSAS SantiagoCHUSAS SantiagoCHUSIntroduction: Measuring soluble interleukin-2 receptor (sIL-2R) might be useful for diagnosis and monitoring of immune-mediated diseases. The study investigated factors associated with serum sIL-2R concentrations in adults. Methods: Serum sIL-2R concentrations were measured in 1499 randomly selected individuals (44.6% male, median age 52 years, range 18-91 years). Lifestyle factors (alcohol consumption, smoking, and physical activity) were assessed by questionnaire. Body mass index and data defining metabolic syndrome were measured in all participants. Atopy was defined by skin tests to aeroallergens. Results: Serum sIL-2R concentrations displayed wide variation (2.5-97.5 percentile range, 209-950 U/mL). A total of 230 (15.3%) individuals showed values higher than the standard reference range (158-623 U/mL). After adjusting for covariates, sIL-2R concentrations increased with age, particularly after 65 years. Serum sIL-2R concentrations were higher in males than in females, were higher in smokers than in never smokers, and were higher in atopic than in non-atopic individuals. Serum sIL-2R concentrations were positively associated with metabolic syndrome, particularly with abdominal obesity, and with a history of ischemic heart disease. Light alcohol drinkers showed lower sIL-2R concentrations than abstainers. Conclusion: Aging, sex, lifestyle factors, atopy, metabolic abnormalities, and ischemic heart disease might influence serum sIL-2R concentrations in adults.The study was supported by grants from the Carlos III Institute of Health (Instituto de Salud Carlos III, PI16/01404 and PI16/01395), the Spanish Network for Additive Disorders (Red de Trastornos Adictivos, RD16/0017/0018, Spanish Ministry of Health), the Spanish Network for Preventive Activity and Health Promotion Research in Primary Care (Red de Actividades Preventivas y de Promocion de Salud en Atencion Primaria, RD16/0007/0006), and the European Regional Development Fund (ERDF).2023info:eu-repo/semantics/articlehttps://portalcientifico.sergas.gal//documentos/64046e82d5b0fa1e7b277182http://hdl.handle.net/20.500.11940/21499reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/214992026-06-12T08:40:47Z
dc.title.none.fl_str_mv Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population study
title Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population study
spellingShingle Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population study
Alende-Castro, V.
AS Santiago
IDIS
AS Santiago
AS Santiago AP
AS Santiago
CHUS
AS Santiago
CHUS
AS Santiago
CHUS
title_short Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population study
title_full Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population study
title_fullStr Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population study
title_full_unstemmed Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population study
title_sort Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population study
dc.creator.none.fl_str_mv Alende-Castro, V.
Alonso Sampedro, Manuela
Fernández Merino, María del Carmen
Sopeña Perez-Argüelles, Bernardo
Vidal, C.
Gude Sampedro, Francisco
González Quintela, Arturo
author Alende-Castro, V.
author_facet Alende-Castro, V.
Alonso Sampedro, Manuela
Fernández Merino, María del Carmen
Sopeña Perez-Argüelles, Bernardo
Vidal, C.
Gude Sampedro, Francisco
González Quintela, Arturo
author_role author
author2 Alonso Sampedro, Manuela
Fernández Merino, María del Carmen
Sopeña Perez-Argüelles, Bernardo
Vidal, C.
Gude Sampedro, Francisco
González Quintela, Arturo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv AS Santiago
IDIS
AS Santiago
AS Santiago AP
AS Santiago
CHUS
AS Santiago
CHUS
AS Santiago
CHUS
topic AS Santiago
IDIS
AS Santiago
AS Santiago AP
AS Santiago
CHUS
AS Santiago
CHUS
AS Santiago
CHUS
description Introduction: Measuring soluble interleukin-2 receptor (sIL-2R) might be useful for diagnosis and monitoring of immune-mediated diseases. The study investigated factors associated with serum sIL-2R concentrations in adults. Methods: Serum sIL-2R concentrations were measured in 1499 randomly selected individuals (44.6% male, median age 52 years, range 18-91 years). Lifestyle factors (alcohol consumption, smoking, and physical activity) were assessed by questionnaire. Body mass index and data defining metabolic syndrome were measured in all participants. Atopy was defined by skin tests to aeroallergens. Results: Serum sIL-2R concentrations displayed wide variation (2.5-97.5 percentile range, 209-950 U/mL). A total of 230 (15.3%) individuals showed values higher than the standard reference range (158-623 U/mL). After adjusting for covariates, sIL-2R concentrations increased with age, particularly after 65 years. Serum sIL-2R concentrations were higher in males than in females, were higher in smokers than in never smokers, and were higher in atopic than in non-atopic individuals. Serum sIL-2R concentrations were positively associated with metabolic syndrome, particularly with abdominal obesity, and with a history of ischemic heart disease. Light alcohol drinkers showed lower sIL-2R concentrations than abstainers. Conclusion: Aging, sex, lifestyle factors, atopy, metabolic abnormalities, and ischemic heart disease might influence serum sIL-2R concentrations in adults.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://portalcientifico.sergas.gal//documentos/64046e82d5b0fa1e7b277182
http://hdl.handle.net/20.500.11940/21499
url https://portalcientifico.sergas.gal//documentos/64046e82d5b0fa1e7b277182
http://hdl.handle.net/20.500.11940/21499
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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