Progression of myopic maculopathy in a Caucasian cohort of highly myopic patients with long follow-up: a multistate analysis

ABSTRACT. PURPOSE This study aims to determine the probability of progression of myopic maculopathy according to age. METHODS This is a longitudinal observational study of single-center retrospective cohort of Caucasian patients formed by 212 consecutive adults with high myopia. Main outcome measure...

Descripción completa

Detalles Bibliográficos
Autores: Coco Martín, Rosa María, Belani Raju, Minal, Fuente Gómez, Daniel de la, Sanabria Ruiz Colmenares, María Rosa, Fernández Martínez, Itziar
Tipo de recurso: artículo
Estado:Versión enviada para evaluación y publicación
Fecha de publicación:2020
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/68942
Acceso en línea:https://doi.org/10.1007/s00417-020-04795-5
https://uvadoc.uva.es/handle/10324/68942
Access Level:acceso abierto
Palabra clave:Choroidal neovascularization
High myopia
Lacquer cracks
Multistate models
Myopic maculopathy
Pathologic myopia
Risk factors of progression
3201.09 Oftalmología
id ES_c953b4f9307989d64f6beb0abc7e00ff
oai_identifier_str oai:uvadoc.uva.es:10324/68942
network_acronym_str ES
network_name_str España
repository_id_str
spelling Progression of myopic maculopathy in a Caucasian cohort of highly myopic patients with long follow-up: a multistate analysisCoco Martín, Rosa MaríaBelani Raju, MinalFuente Gómez, Daniel de laSanabria Ruiz Colmenares, María RosaFernández Martínez, ItziarChoroidal neovascularizationHigh myopiaLacquer cracksMultistate modelsMyopic maculopathyPathologic myopiaRisk factors of progression3201.09 OftalmologíaABSTRACT. PURPOSE This study aims to determine the probability of progression of myopic maculopathy according to age. METHODS This is a longitudinal observational study of single-center retrospective cohort of Caucasian patients formed by 212 consecutive adults with high myopia. Main outcome measures were age, visual acuity (VA), refractive error (RE), follow-up time, and the macular status assessed at least 5 years apart according to the Meta-Analysis of Pathologic Myopia Study Group. The progression rate was calculated based on per 1000 eyes/year.Multistate models were fitted to identify the predictive factors and to calculate the most probable age of progression onset using the Aalen–Johansen estimator. RESULTS We studied 220 eyes of 122 Caucasian patients. Mean age was 48.18 ± 14.1, mean follow-up 12.73 ± 5.81 years. One hundred and fifty-two (69.1%) eyes progressed of category, and 96 (44%) worsened a mean of 0.3 logMAR units during followup. The progression rate was 32.21/1000 eyes/year. The probability of progressing increased with age; it was higher in women if there was a family history of myopia, worse VA, higher RE, or wide macular staphyloma. The probability of progressing from category 1 was > 0.6 after 70 years of age; from category 2, it was 0.7 after 70 years; and 0.5 from category 3 after 75 years. If choroidal neovascularization (CNV) appeared, this probability exceeded 0.7 between ages 45 and 55 for all categories. CONCLUSION The progression rate is lower than in a Japanese series. The vision worsened with disease progression, and the probability of both happening increased after the age of 70–75. If CNV appears, the risk of progression is very high at the age of 45–55.Springer Nature2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/submittedVersionapplication/pdfhttps://doi.org/10.1007/s00417-020-04795-5https://uvadoc.uva.es/handle/10324/68942reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidEspañolhttps://link.springer.com/article/10.1007/s00417-020-04795-5info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/689422026-06-13T12:44:47Z
dc.title.none.fl_str_mv Progression of myopic maculopathy in a Caucasian cohort of highly myopic patients with long follow-up: a multistate analysis
title Progression of myopic maculopathy in a Caucasian cohort of highly myopic patients with long follow-up: a multistate analysis
spellingShingle Progression of myopic maculopathy in a Caucasian cohort of highly myopic patients with long follow-up: a multistate analysis
Coco Martín, Rosa María
Choroidal neovascularization
High myopia
Lacquer cracks
Multistate models
Myopic maculopathy
Pathologic myopia
Risk factors of progression
3201.09 Oftalmología
title_short Progression of myopic maculopathy in a Caucasian cohort of highly myopic patients with long follow-up: a multistate analysis
title_full Progression of myopic maculopathy in a Caucasian cohort of highly myopic patients with long follow-up: a multistate analysis
title_fullStr Progression of myopic maculopathy in a Caucasian cohort of highly myopic patients with long follow-up: a multistate analysis
title_full_unstemmed Progression of myopic maculopathy in a Caucasian cohort of highly myopic patients with long follow-up: a multistate analysis
title_sort Progression of myopic maculopathy in a Caucasian cohort of highly myopic patients with long follow-up: a multistate analysis
dc.creator.none.fl_str_mv Coco Martín, Rosa María
Belani Raju, Minal
Fuente Gómez, Daniel de la
Sanabria Ruiz Colmenares, María Rosa
Fernández Martínez, Itziar
author Coco Martín, Rosa María
author_facet Coco Martín, Rosa María
Belani Raju, Minal
Fuente Gómez, Daniel de la
Sanabria Ruiz Colmenares, María Rosa
Fernández Martínez, Itziar
author_role author
author2 Belani Raju, Minal
Fuente Gómez, Daniel de la
Sanabria Ruiz Colmenares, María Rosa
Fernández Martínez, Itziar
author2_role author
author
author
author
dc.subject.none.fl_str_mv Choroidal neovascularization
High myopia
Lacquer cracks
Multistate models
Myopic maculopathy
Pathologic myopia
Risk factors of progression
3201.09 Oftalmología
topic Choroidal neovascularization
High myopia
Lacquer cracks
Multistate models
Myopic maculopathy
Pathologic myopia
Risk factors of progression
3201.09 Oftalmología
description ABSTRACT. PURPOSE This study aims to determine the probability of progression of myopic maculopathy according to age. METHODS This is a longitudinal observational study of single-center retrospective cohort of Caucasian patients formed by 212 consecutive adults with high myopia. Main outcome measures were age, visual acuity (VA), refractive error (RE), follow-up time, and the macular status assessed at least 5 years apart according to the Meta-Analysis of Pathologic Myopia Study Group. The progression rate was calculated based on per 1000 eyes/year.Multistate models were fitted to identify the predictive factors and to calculate the most probable age of progression onset using the Aalen–Johansen estimator. RESULTS We studied 220 eyes of 122 Caucasian patients. Mean age was 48.18 ± 14.1, mean follow-up 12.73 ± 5.81 years. One hundred and fifty-two (69.1%) eyes progressed of category, and 96 (44%) worsened a mean of 0.3 logMAR units during followup. The progression rate was 32.21/1000 eyes/year. The probability of progressing increased with age; it was higher in women if there was a family history of myopia, worse VA, higher RE, or wide macular staphyloma. The probability of progressing from category 1 was > 0.6 after 70 years of age; from category 2, it was 0.7 after 70 years; and 0.5 from category 3 after 75 years. If choroidal neovascularization (CNV) appeared, this probability exceeded 0.7 between ages 45 and 55 for all categories. CONCLUSION The progression rate is lower than in a Japanese series. The vision worsened with disease progression, and the probability of both happening increased after the age of 70–75. If CNV appears, the risk of progression is very high at the age of 45–55.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/submittedVersion
format article
status_str submittedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1007/s00417-020-04795-5
https://uvadoc.uva.es/handle/10324/68942
url https://doi.org/10.1007/s00417-020-04795-5
https://uvadoc.uva.es/handle/10324/68942
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.relation.none.fl_str_mv https://link.springer.com/article/10.1007/s00417-020-04795-5
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419361691762688
score 15,811543

Similares en LA Referencia