Effects and underlying mechanisms of bioactive compounds-enriched diets against obesity and associated pathologies
[eng] Bioactive compounds have long been proposed as a tool to help facing both obesity and its comorbidities pandemic. Knowledge on their properties, together with the discovery of new therapeutic targets in animals and humans, make then interesting proposals for the prevention and treatment of var...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/192945 |
| Acceso en línea: | https://hdl.handle.net/2445/192945 http://hdl.handle.net/10803/687562 |
| Access Level: | acceso abierto |
| Palabra clave: | Obesitat Compostos bioactius Receptors cel·lulars Malalties del fetge Obesity Bioactive compounds Cell receptors Liver diseases |
| Sumario: | [eng] Bioactive compounds have long been proposed as a tool to help facing both obesity and its comorbidities pandemic. Knowledge on their properties, together with the discovery of new therapeutic targets in animals and humans, make then interesting proposals for the prevention and treatment of various metabolic diseases. One of the main parts of this thesis proposal was to evaluate the ability of a pure, isolated polyphenol supplementation to counteract the pernicious metabolic effects of a high-fat diet on a murine model. Contrary to expectations, the polyphenolic supplementation worsened the action of the high-fat diet and pointedly produced an aggression to the kidneys. The other main part of this thesis proposal had been to assess a natural source of bioactive compounds with a broad and diverse profile not only in phenolic species, on a diet-obesity model. Based on the experience of our research group and the positive results demonstrated in different studies on chronic diseases, the Rosa canina fruit was chosen. In this case it was demonstrated how the supplementation with Rosa canina flesh was able to slow down the pernicious effect of the high fat diet, and particularly how exhibited a strong anti-steatotic effect on liver by downregulating several key genes, and thus improving significantly the non-alcoholic fatty liver disease course on obese mice. Furthermore, through the flesh fractionation, bioactive compound characterization and in vitro analysis, it was possible to identify that the most lipophilic phases of the Rosa canina show an antagonistic role on the peroxisome proliferator activated receptor gamma and therefore were partly responsible for the observed anti-steatotic effect. |
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