CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia

Excessive microglial activation might be a central pathological process in GRN-related frontotemporal dementia (FTD-GRN). We measured soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which is shed from disease-associated microglia following cleavage of TREM2, in cerebrospinal fluid...

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Autores: van der Ende, EL, Morenas-Rodriguez, E, McMillan, C, Grossman, M, Irwin, D, Sanchez-Valle, R, Graff, C, Vandenberghe, R, Pijnenburg, YAL, Laforce, R, Le Ber, I, Lleo, A, Haass, C, Suarez-Calvet, M, van Swieten, JC, Seelaar, H
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p4582
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4582
https://ddd.uab.cat/record/271896
Access Level:acceso abierto
Palabra clave:Frontotemporal dementia
Biomarker
Cerebrospinal fluid
Microglia
sTREM2
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spelling CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementiavan der Ende, ELMorenas-Rodriguez, EMcMillan, CGrossman, MIrwin, DSanchez-Valle, RGraff, CVandenberghe, RPijnenburg, YALLaforce, RLe Ber, ILleo, AHaass, CSuarez-Calvet, Mvan Swieten, JCSeelaar, HFrontotemporal dementiaBiomarkerCerebrospinal fluidMicrogliasTREM2Excessive microglial activation might be a central pathological process in GRN-related frontotemporal dementia (FTD-GRN). We measured soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which is shed from disease-associated microglia following cleavage of TREM2, in cerebrospinal fluid of 34 presymptomatic and 35 symptomatic GRN mutation carriers, 6 presymptomatic and 32 symptomatic C9orf72 mutation carriers and 67 healthy noncarriers by ELISA. Although no group differences in sTREM2 levels were observed (GRN: symptomatic (median 5.2 ng/mL, interquartile range [3.9-9.2]) vs. presymptomatic (4.3 ng/mL [2.6-6.1]) vs. noncarriers (4.2 ng/mL [2.6-5.5]): p = 0.059; C9orf72: symptomatic (4.3 [2.9-7.0]) vs. presymptomatic (3.2 [2.2-4.2]) vs. noncarriers: p = 0.294), high levels were seen in a subset of GRN, but not C9orf72, mutation carriers, which might reflect differential TREM2-related microglial activation. Interestingly, 2 presymptomatic carriers with low sTREM2 levels developed symptoms after 1 year, whereas 2 with high levels became symptomatic after >5 years. While sTREM2 is not a promising diagnostic biomarker for FTD-GRN or FTD-C9orf72, further research might elucidate its potential to monitor microglial activity and predict disease progression. (C) 2021 The Authors. Published by Elsevier Inc.ELSEVIER SCIENCE INC2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4582https://ddd.uab.cat/record/271896NEUROBIOLOGY OF AGINGISSN: 01974580ISSNe: 15581497reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p45822026-06-14T12:41:47Z
dc.title.none.fl_str_mv CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
title CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
spellingShingle CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
van der Ende, EL
Frontotemporal dementia
Biomarker
Cerebrospinal fluid
Microglia
sTREM2
title_short CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
title_full CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
title_fullStr CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
title_full_unstemmed CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
title_sort CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia
dc.creator.none.fl_str_mv van der Ende, EL
Morenas-Rodriguez, E
McMillan, C
Grossman, M
Irwin, D
Sanchez-Valle, R
Graff, C
Vandenberghe, R
Pijnenburg, YAL
Laforce, R
Le Ber, I
Lleo, A
Haass, C
Suarez-Calvet, M
van Swieten, JC
Seelaar, H
author van der Ende, EL
author_facet van der Ende, EL
Morenas-Rodriguez, E
McMillan, C
Grossman, M
Irwin, D
Sanchez-Valle, R
Graff, C
Vandenberghe, R
Pijnenburg, YAL
Laforce, R
Le Ber, I
Lleo, A
Haass, C
Suarez-Calvet, M
van Swieten, JC
Seelaar, H
author_role author
author2 Morenas-Rodriguez, E
McMillan, C
Grossman, M
Irwin, D
Sanchez-Valle, R
Graff, C
Vandenberghe, R
Pijnenburg, YAL
Laforce, R
Le Ber, I
Lleo, A
Haass, C
Suarez-Calvet, M
van Swieten, JC
Seelaar, H
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Frontotemporal dementia
Biomarker
Cerebrospinal fluid
Microglia
sTREM2
topic Frontotemporal dementia
Biomarker
Cerebrospinal fluid
Microglia
sTREM2
description Excessive microglial activation might be a central pathological process in GRN-related frontotemporal dementia (FTD-GRN). We measured soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which is shed from disease-associated microglia following cleavage of TREM2, in cerebrospinal fluid of 34 presymptomatic and 35 symptomatic GRN mutation carriers, 6 presymptomatic and 32 symptomatic C9orf72 mutation carriers and 67 healthy noncarriers by ELISA. Although no group differences in sTREM2 levels were observed (GRN: symptomatic (median 5.2 ng/mL, interquartile range [3.9-9.2]) vs. presymptomatic (4.3 ng/mL [2.6-6.1]) vs. noncarriers (4.2 ng/mL [2.6-5.5]): p = 0.059; C9orf72: symptomatic (4.3 [2.9-7.0]) vs. presymptomatic (3.2 [2.2-4.2]) vs. noncarriers: p = 0.294), high levels were seen in a subset of GRN, but not C9orf72, mutation carriers, which might reflect differential TREM2-related microglial activation. Interestingly, 2 presymptomatic carriers with low sTREM2 levels developed symptoms after 1 year, whereas 2 with high levels became symptomatic after >5 years. While sTREM2 is not a promising diagnostic biomarker for FTD-GRN or FTD-C9orf72, further research might elucidate its potential to monitor microglial activity and predict disease progression. (C) 2021 The Authors. Published by Elsevier Inc.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4582
https://ddd.uab.cat/record/271896
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4582
https://ddd.uab.cat/record/271896
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCIENCE INC
publisher.none.fl_str_mv ELSEVIER SCIENCE INC
dc.source.none.fl_str_mv NEUROBIOLOGY OF AGING
ISSN: 01974580
ISSNe: 15581497
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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