Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases.

Sánchez-Castillo, Ana Isabel; Sepúlveda, M. Rosario; Marín-Teva, José Luis; Cuadros, Miguel A.; Martín-Oliva, David; González-Rey, Elena; Delgado, Mario; Neubrand, Veronika E.

Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases.

Neurological disorders, including neurodegenerative diseases, are often characterized by neuroinflammation, which is largely driven by microglia, the resident immune cells of the central nervous system (CNS). Under these conditions, microglia are able to secrete neurotoxic substances, provoking neur...

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Autores:	Sánchez-Castillo, Ana Isabel, Sepúlveda, M. Rosario, Marín-Teva, José Luis, Cuadros, Miguel A., Martín-Oliva, David, González-Rey, Elena, Delgado, Mario, Neubrand, Veronika E.
Tipo de recurso:	artículo
Fecha de publicación:	2022
País:	España
Institución:	Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:	DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:	oai:digital.csic.es:10261/358503
Acceso en línea:	http://hdl.handle.net/10261/358503
Access Level:	acceso abierto
Palabra clave:	adipose tissue-derived mesenchymal stem cells extracellular vesicles microglia neurodegenerative diseases neuroinflammation neuroprotection

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spelling	Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases.Sánchez-Castillo, Ana IsabelSepúlveda, M. RosarioMarín-Teva, José LuisCuadros, Miguel A.Martín-Oliva, DavidGonzález-Rey, ElenaDelgado, MarioNeubrand, Veronika E.adiposetissue-derived mesenchymal stem cellsextracellular vesiclesmicroglianeurodegenerative diseasesneuroinflammationneuroprotectionNeurological disorders, including neurodegenerative diseases, are often characterized by neuroinflammation, which is largely driven by microglia, the resident immune cells of the central nervous system (CNS). Under these conditions, microglia are able to secrete neurotoxic substances, provoking neuronal cell death. However, microglia in the healthy brain carry out CNS-supporting functions. This is due to the ability of microglia to acquire different phenotypes that can play a neuroprotective role under physiological conditions or a pro-inflammatory, damaging one during disease. Therefore, therapeutic strategies focus on the downregulation of these neuroinflammatory processes and try to re-activate the neuroprotective features of microglia. Mesenchymal stem cells (MSC) of different origins have been shown to exert such effects, due to their immunomodulatory properties. In recent years, MSC derived from adipose tissue have been made the center of attention because of their easy availability and extraction methods. These cells induce a neuroprotective phenotype in microglia and downregulate neuroinflammation, resulting in an improvement of clinical symptoms in a variety of animal models for neurological pathologies, e.g., Alzheimer¿s disease, traumatic brain injury and ischemic stroke. In this review, we will discuss the application of adipose tissue-derived MSC and their conditioned medium, including extracellular vesicles, in neurological disorders, their beneficial effect on microglia and the signaling pathways involved.This research was funded by the Andalusian Government, Spain (grant no. P20-01255 to M.D. and FEDER program grant no. A1-CTS-324-UGR18 to M.R.S.) and by the Spanish Ministry for Economy and Competition, Spain (grant no. SAF2017-85602-R and PID2020-119638RB-I00, both to E.G.-R.). A.I.S.-C. was the awardee of a Research Starting Fellowship for master´s students at the University of Granada, Spain. The APC was funded by MDPI.Junta de AndalucíaMinisterio de Economía y Competitividad (España)Universidad de GranadaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2024202420222024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bchttp://hdl.handle.net/10261/358503reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.3390/biom12020219Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3585032026-05-22T06:33:51Z
dc.title.none.fl_str_mv	Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases.
title	Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases.
spellingShingle	Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases. Sánchez-Castillo, Ana Isabel adipose tissue-derived mesenchymal stem cells extracellular vesicles microglia neurodegenerative diseases neuroinflammation neuroprotection
title_short	Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases.
title_full	Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases.
title_fullStr	Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases.
title_full_unstemmed	Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases.
title_sort	Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases.
dc.creator.none.fl_str_mv	Sánchez-Castillo, Ana Isabel Sepúlveda, M. Rosario Marín-Teva, José Luis Cuadros, Miguel A. Martín-Oliva, David González-Rey, Elena Delgado, Mario Neubrand, Veronika E.
author	Sánchez-Castillo, Ana Isabel
author_facet	Sánchez-Castillo, Ana Isabel Sepúlveda, M. Rosario Marín-Teva, José Luis Cuadros, Miguel A. Martín-Oliva, David González-Rey, Elena Delgado, Mario Neubrand, Veronika E.
author_role	author
author2	Sepúlveda, M. Rosario Marín-Teva, José Luis Cuadros, Miguel A. Martín-Oliva, David González-Rey, Elena Delgado, Mario Neubrand, Veronika E.
author2_role	author author author author author author author
dc.contributor.none.fl_str_mv	Junta de Andalucía Ministerio de Economía y Competitividad (España) Universidad de Granada Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv	adipose tissue-derived mesenchymal stem cells extracellular vesicles microglia neurodegenerative diseases neuroinflammation neuroprotection
topic	adipose tissue-derived mesenchymal stem cells extracellular vesicles microglia neurodegenerative diseases neuroinflammation neuroprotection
description	Neurological disorders, including neurodegenerative diseases, are often characterized by neuroinflammation, which is largely driven by microglia, the resident immune cells of the central nervous system (CNS). Under these conditions, microglia are able to secrete neurotoxic substances, provoking neuronal cell death. However, microglia in the healthy brain carry out CNS-supporting functions. This is due to the ability of microglia to acquire different phenotypes that can play a neuroprotective role under physiological conditions or a pro-inflammatory, damaging one during disease. Therefore, therapeutic strategies focus on the downregulation of these neuroinflammatory processes and try to re-activate the neuroprotective features of microglia. Mesenchymal stem cells (MSC) of different origins have been shown to exert such effects, due to their immunomodulatory properties. In recent years, MSC derived from adipose tissue have been made the center of attention because of their easy availability and extraction methods. These cells induce a neuroprotective phenotype in microglia and downregulate neuroinflammation, resulting in an improvement of clinical symptoms in a variety of animal models for neurological pathologies, e.g., Alzheimer¿s disease, traumatic brain injury and ischemic stroke. In this review, we will discuss the application of adipose tissue-derived MSC and their conditioned medium, including extracellular vesicles, in neurological disorders, their beneficial effect on microglia and the signaling pathways involved.
publishDate	2022
dc.date.none.fl_str_mv	2022 2024 2024 2024
dc.type.none.fl_str_mv	info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_dcae04bc
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10261/358503
url	http://hdl.handle.net/10261/358503
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	http://dx.doi.org/10.3390/biom12020219 Sí
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str	Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str	DIGITAL.CSIC. Repositorio Institucional del CSIC
collection	DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,81155

Switching Roles: Beneficial Effects of Adipose Tissue-Derived Mesenchymal Stem Cells on Microglia and Their Implication in Neurodegenerative Diseases.

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