The transcription factor code: a beacon for histone methyltransferase docking

Histone methylation is required for the establishment and maintenance of gene expression patterns that determine cellular identity, and its perturbation often leads to aberrant development and disease. Recruitment of histone methyltransferases (HMTs) to gene regulatory elements (GREs) of development...

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Detalles Bibliográficos
Autores: Torcal Garcia, Guillem, 1991-, Graf, T. (Thomas)
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/48177
Acceso en línea:http://hdl.handle.net/10230/48177
http://dx.doi.org/10.1016/j.tcb.2021.04.001
Access Level:acceso abierto
Palabra clave:Gene regulation
Histone methylation
Histone methyltransferase
Post-translational modification
Transcription factor
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spelling The transcription factor code: a beacon for histone methyltransferase dockingTorcal Garcia, Guillem, 1991-Graf, T. (Thomas)Gene regulationHistone methylationHistone methyltransferasePost-translational modificationTranscription factorHistone methylation is required for the establishment and maintenance of gene expression patterns that determine cellular identity, and its perturbation often leads to aberrant development and disease. Recruitment of histone methyltransferases (HMTs) to gene regulatory elements (GREs) of developmental genes is important for the correct activation and silencing of these genes, but the drivers of this recruitment are largely unknown. Here we propose that lineage-instructive transcription factors (Lin-TFs) act as general recruiters of HMT complexes to cell type-specific GREs through protein-protein interactions. We also postulate that the specificity of these interactions is dictated by Lin-TF post-translational modifications (PTMs), which act as a 'transcription factor code' that can determine the directionality of cell fate decisions during differentiation and development.Elsevier20212021info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/48177http://dx.doi.org/10.1016/j.tcb.2021.04.001reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésTrends Cell Biol. 2021 Oct;31(10):792-800© Elsevier http://dx.doi.org/10.1016/j.tcb.2021.04.001info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/481772026-06-12T07:21:37Z
dc.title.none.fl_str_mv The transcription factor code: a beacon for histone methyltransferase docking
title The transcription factor code: a beacon for histone methyltransferase docking
spellingShingle The transcription factor code: a beacon for histone methyltransferase docking
Torcal Garcia, Guillem, 1991-
Gene regulation
Histone methylation
Histone methyltransferase
Post-translational modification
Transcription factor
title_short The transcription factor code: a beacon for histone methyltransferase docking
title_full The transcription factor code: a beacon for histone methyltransferase docking
title_fullStr The transcription factor code: a beacon for histone methyltransferase docking
title_full_unstemmed The transcription factor code: a beacon for histone methyltransferase docking
title_sort The transcription factor code: a beacon for histone methyltransferase docking
dc.creator.none.fl_str_mv Torcal Garcia, Guillem, 1991-
Graf, T. (Thomas)
author Torcal Garcia, Guillem, 1991-
author_facet Torcal Garcia, Guillem, 1991-
Graf, T. (Thomas)
author_role author
author2 Graf, T. (Thomas)
author2_role author
dc.subject.none.fl_str_mv Gene regulation
Histone methylation
Histone methyltransferase
Post-translational modification
Transcription factor
topic Gene regulation
Histone methylation
Histone methyltransferase
Post-translational modification
Transcription factor
description Histone methylation is required for the establishment and maintenance of gene expression patterns that determine cellular identity, and its perturbation often leads to aberrant development and disease. Recruitment of histone methyltransferases (HMTs) to gene regulatory elements (GREs) of developmental genes is important for the correct activation and silencing of these genes, but the drivers of this recruitment are largely unknown. Here we propose that lineage-instructive transcription factors (Lin-TFs) act as general recruiters of HMT complexes to cell type-specific GREs through protein-protein interactions. We also postulate that the specificity of these interactions is dictated by Lin-TF post-translational modifications (PTMs), which act as a 'transcription factor code' that can determine the directionality of cell fate decisions during differentiation and development.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/48177
http://dx.doi.org/10.1016/j.tcb.2021.04.001
url http://hdl.handle.net/10230/48177
http://dx.doi.org/10.1016/j.tcb.2021.04.001
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Trends Cell Biol. 2021 Oct;31(10):792-800
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.tcb.2021.04.001
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.tcb.2021.04.001
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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