Elevated Plasma Reelin Levels in Children With Autism

Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders involving age-dependent gene dysregulation. Reelin is a glycoprotein that varies its expression throughout lifetime and controls cortical patterning and synaptogenesis. Brain and plasma reelin levels have been reported to be l...

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Autores: Cuchillo-Ibanez, I, Andreo-Lillo, P, Pastor-Ferrandiz, L, Carratala-Marco, F, Saez-Valero, J
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
Repositorio:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
OAI Identifier:oai:isabial.fundanetsuite.com:p8768
Acceso en línea:https://isabial.portalinvestigacion.com/publicaciones8768
Access Level:acceso abierto
Palabra clave:reelin
autism
children
enzyme-linked immunosorbent assay
Western blotting
dimers
oligomers
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repository_id_str
spelling Elevated Plasma Reelin Levels in Children With AutismCuchillo-Ibanez, IAndreo-Lillo, PPastor-Ferrandiz, LCarratala-Marco, FSaez-Valero, Jreelinautismchildrenenzyme-linked immunosorbent assayWestern blottingdimersoligomersAutism spectrum disorder (ASD) is a group of neurodevelopmental disorders involving age-dependent gene dysregulation. Reelin is a glycoprotein that varies its expression throughout lifetime and controls cortical patterning and synaptogenesis. Brain and plasma reelin levels have been reported to be low in adults with autism; as well as in children with autism, but only when compared to control adults. Therefore, reelin expression levels in children with autism are unclear. For this reason, we compared plasma reelin levels in children with autism and children without autism (non-ASD) of similar ages to evaluate reelin expression in ASD during childhood. Plasma samples from 19 non-ASD (8.9 +/- 0.8 years) and 40 children with autism (7.5 +/- 0.5 years) were analyzed. We found that 50% of the children with autism displayed similar plasma reelin levels to the non-ASD group. However, the remaining 50% expressed more than 30 times more reelin compared to non-ASD levels. We also show that male children with autism displayed significantly higher reelin levels than females. The clinical presentation of this subgroup could not be distinguished from that of children with autism. Epilepsy or attention-deficit/hyperactivity disorder (ADHD) was not associated to reelin levels. We conclude that the high levels of plasma reelin might be an important hallmark in a subset of children with autism, previously unnoticed. As we could not find any correlation between reelin levels and ASD clinical presentations, our results may indicate transient reelin increases in the plasma or the characterization of a group of ASD individuals with a different pathophysiology.FRONTIERS MEDIA SA2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://isabial.portalinvestigacion.com/publicaciones8768Frontiers in PsychiatryISSN: 16640640reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicanteinstname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)Inglésinfo:eu-repo/semantics/openAccessoai:isabial.fundanetsuite.com:p87682026-06-12T10:20:37Z
dc.title.none.fl_str_mv Elevated Plasma Reelin Levels in Children With Autism
title Elevated Plasma Reelin Levels in Children With Autism
spellingShingle Elevated Plasma Reelin Levels in Children With Autism
Cuchillo-Ibanez, I
reelin
autism
children
enzyme-linked immunosorbent assay
Western blotting
dimers
oligomers
title_short Elevated Plasma Reelin Levels in Children With Autism
title_full Elevated Plasma Reelin Levels in Children With Autism
title_fullStr Elevated Plasma Reelin Levels in Children With Autism
title_full_unstemmed Elevated Plasma Reelin Levels in Children With Autism
title_sort Elevated Plasma Reelin Levels in Children With Autism
dc.creator.none.fl_str_mv Cuchillo-Ibanez, I
Andreo-Lillo, P
Pastor-Ferrandiz, L
Carratala-Marco, F
Saez-Valero, J
author Cuchillo-Ibanez, I
author_facet Cuchillo-Ibanez, I
Andreo-Lillo, P
Pastor-Ferrandiz, L
Carratala-Marco, F
Saez-Valero, J
author_role author
author2 Andreo-Lillo, P
Pastor-Ferrandiz, L
Carratala-Marco, F
Saez-Valero, J
author2_role author
author
author
author
dc.subject.none.fl_str_mv reelin
autism
children
enzyme-linked immunosorbent assay
Western blotting
dimers
oligomers
topic reelin
autism
children
enzyme-linked immunosorbent assay
Western blotting
dimers
oligomers
description Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders involving age-dependent gene dysregulation. Reelin is a glycoprotein that varies its expression throughout lifetime and controls cortical patterning and synaptogenesis. Brain and plasma reelin levels have been reported to be low in adults with autism; as well as in children with autism, but only when compared to control adults. Therefore, reelin expression levels in children with autism are unclear. For this reason, we compared plasma reelin levels in children with autism and children without autism (non-ASD) of similar ages to evaluate reelin expression in ASD during childhood. Plasma samples from 19 non-ASD (8.9 +/- 0.8 years) and 40 children with autism (7.5 +/- 0.5 years) were analyzed. We found that 50% of the children with autism displayed similar plasma reelin levels to the non-ASD group. However, the remaining 50% expressed more than 30 times more reelin compared to non-ASD levels. We also show that male children with autism displayed significantly higher reelin levels than females. The clinical presentation of this subgroup could not be distinguished from that of children with autism. Epilepsy or attention-deficit/hyperactivity disorder (ADHD) was not associated to reelin levels. We conclude that the high levels of plasma reelin might be an important hallmark in a subset of children with autism, previously unnoticed. As we could not find any correlation between reelin levels and ASD clinical presentations, our results may indicate transient reelin increases in the plasma or the characterization of a group of ASD individuals with a different pathophysiology.
publishDate 2020
dc.date.none.fl_str_mv 2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://isabial.portalinvestigacion.com/publicaciones8768
url https://isabial.portalinvestigacion.com/publicaciones8768
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv FRONTIERS MEDIA SA
publisher.none.fl_str_mv FRONTIERS MEDIA SA
dc.source.none.fl_str_mv Frontiers in Psychiatry
ISSN: 16640640
reponame:r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname:Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
instname_str Instituto de Investigación Biomédica y Sanitaria de Alicante (ISABIAL)
reponame_str r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
collection r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
repository.name.fl_str_mv
repository.mail.fl_str_mv
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