Decreased human sperm motility and vitality after fast gravity load changes in a parabolic flight

Little is known about the effects of low gravity on human gametes. The aim of this study was to analyze if fresh human sperm samples after fast gravity load changes suffered any detrimental effect in comparison to the splits maintained in Earth's gravity. Fifteen fresh samples from normozoosper...

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Detalles Bibliográficos
Autores: Perez-Poch, Antoni, Ballester, Marta, Tresanchez, Marta, Torner, Jordi, González, Daniel V., Alpiste, Francesc, Brigos, Miguel, Sánchez, Eduard, Martínez, Gloria, García, Sandra, Polyzos, Nikolaos P., Boada, Montserrat
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/371236
Acceso en línea:http://hdl.handle.net/10261/371236
Access Level:acceso abierto
Palabra clave:Parabolic flight
Space
Sperm motility
Human reproduction
Assisted reproduction techniques
Microgravity
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spelling Decreased human sperm motility and vitality after fast gravity load changes in a parabolic flightPerez-Poch, AntoniBallester, MartaTresanchez, MartaTorner, JordiGonzález, Daniel V.Alpiste, FrancescBrigos, MiguelSánchez, EduardMartínez, GloriaGarcía, SandraPolyzos, Nikolaos P.Boada, MontserratParabolic flightSpaceSperm motilityHuman reproductionAssisted reproduction techniquesMicrogravityLittle is known about the effects of low gravity on human gametes. The aim of this study was to analyze if fresh human sperm samples after fast gravity load changes suffered any detrimental effect in comparison to the splits maintained in Earth's gravity. Fifteen fresh samples from normozoospermic donors were analyzed. Statistically significant differences in vitality (69.7 ± 9.9 % vs 72.4 ± 9.7 %, [95 % CI: 0.002,0.07]); motile sperm concentration (23.7 ± 15.3 M/ml vs 31.5 ± 25.1 M/ml, [95 % CI: 1.03,14.65]); grade “a” sperm concentration (8.7 ± 6.5 M/ml vs 11.7 ± 9.9 M/ml, [95 % CI: 0.71,5.28]); percentage of progressive motility sperm (30 ± 12.9 % vs 36 ± 14.3 %, [95 % CI: 0.10,0.37]) and curvilinear velocity VCL: 45.7 ± 12.8 μm/s vs 47.7 ± 13.3 μm/s, [95 % CI: 0.79,3.22]) were observed. No statistical differences were observed in other sperm kinematic parameters, morphology, DNA fragmentation, apoptosis, and oxidative stress. In conclusion, even though it did not result in a total loss, heavy gravity load changes including microgravity causes a significant decrease in sperm vitality and motility suggesting that negative consequences would be even higher if the exposure were longer. The results obtained indicate that further research is really needed before Assisted Reproduction will be considered for the future human reproduction outside the Earth.Peer reviewedElsevier202420242024info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/371236reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1016/j.actaastro.2024.07.050Noinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3712362026-05-22T06:33:51Z
dc.title.none.fl_str_mv Decreased human sperm motility and vitality after fast gravity load changes in a parabolic flight
title Decreased human sperm motility and vitality after fast gravity load changes in a parabolic flight
spellingShingle Decreased human sperm motility and vitality after fast gravity load changes in a parabolic flight
Perez-Poch, Antoni
Parabolic flight
Space
Sperm motility
Human reproduction
Assisted reproduction techniques
Microgravity
title_short Decreased human sperm motility and vitality after fast gravity load changes in a parabolic flight
title_full Decreased human sperm motility and vitality after fast gravity load changes in a parabolic flight
title_fullStr Decreased human sperm motility and vitality after fast gravity load changes in a parabolic flight
title_full_unstemmed Decreased human sperm motility and vitality after fast gravity load changes in a parabolic flight
title_sort Decreased human sperm motility and vitality after fast gravity load changes in a parabolic flight
dc.creator.none.fl_str_mv Perez-Poch, Antoni
Ballester, Marta
Tresanchez, Marta
Torner, Jordi
González, Daniel V.
Alpiste, Francesc
Brigos, Miguel
Sánchez, Eduard
Martínez, Gloria
García, Sandra
Polyzos, Nikolaos P.
Boada, Montserrat
author Perez-Poch, Antoni
author_facet Perez-Poch, Antoni
Ballester, Marta
Tresanchez, Marta
Torner, Jordi
González, Daniel V.
Alpiste, Francesc
Brigos, Miguel
Sánchez, Eduard
Martínez, Gloria
García, Sandra
Polyzos, Nikolaos P.
Boada, Montserrat
author_role author
author2 Ballester, Marta
Tresanchez, Marta
Torner, Jordi
González, Daniel V.
Alpiste, Francesc
Brigos, Miguel
Sánchez, Eduard
Martínez, Gloria
García, Sandra
Polyzos, Nikolaos P.
Boada, Montserrat
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Parabolic flight
Space
Sperm motility
Human reproduction
Assisted reproduction techniques
Microgravity
topic Parabolic flight
Space
Sperm motility
Human reproduction
Assisted reproduction techniques
Microgravity
description Little is known about the effects of low gravity on human gametes. The aim of this study was to analyze if fresh human sperm samples after fast gravity load changes suffered any detrimental effect in comparison to the splits maintained in Earth's gravity. Fifteen fresh samples from normozoospermic donors were analyzed. Statistically significant differences in vitality (69.7 ± 9.9 % vs 72.4 ± 9.7 %, [95 % CI: 0.002,0.07]); motile sperm concentration (23.7 ± 15.3 M/ml vs 31.5 ± 25.1 M/ml, [95 % CI: 1.03,14.65]); grade “a” sperm concentration (8.7 ± 6.5 M/ml vs 11.7 ± 9.9 M/ml, [95 % CI: 0.71,5.28]); percentage of progressive motility sperm (30 ± 12.9 % vs 36 ± 14.3 %, [95 % CI: 0.10,0.37]) and curvilinear velocity VCL: 45.7 ± 12.8 μm/s vs 47.7 ± 13.3 μm/s, [95 % CI: 0.79,3.22]) were observed. No statistical differences were observed in other sperm kinematic parameters, morphology, DNA fragmentation, apoptosis, and oxidative stress. In conclusion, even though it did not result in a total loss, heavy gravity load changes including microgravity causes a significant decrease in sperm vitality and motility suggesting that negative consequences would be even higher if the exposure were longer. The results obtained indicate that further research is really needed before Assisted Reproduction will be considered for the future human reproduction outside the Earth.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/371236
url http://hdl.handle.net/10261/371236
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1016/j.actaastro.2024.07.050
No
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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