Peptidylglycine alpha-amidating monooxygenase- and proadrenomedullin-derived peptide-associated neuroendocrine differentiation are induced by androgen deprivation in the neoplastic prostate

Most PCs show NE differentiation. Several studies have tried to correlate NE expression with disease status, but the reported findings have been contradictory. Prostatic NE cells synthesize peptides with a wide spectrum of potential functions. Some of these active peptides, such as PAMP, are amidate...

ver descrição completa

Detalhes bibliográficos
Autores: Jimenez, N. (Nuria)|||/items/f30692dd-977b-4208-8cdd-35ce1f668019, Jongsma, J. (Johan)|||/items/47307705-db15-4c77-98e8-b54451d51ced, Calvo-González, A. (Alfonso)|||/items/ac176653-87d5-476b-b2b9-ade455cfa6de, Kwast, T.H. (Theodorus H. ) van der|||/items/c968ed25-ffcd-432c-b2a1-d31dd5634673, Treston, A.M. (Anthony M.)|||/items/2a2177c8-e6d5-486c-841e-62a5423a037b, Cuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188, Schröder, F.H. (Fritz H.)|||/items/f324355b-576d-4b27-817f-0fca445a90aa, Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596, Steenbrugge, G.J. (Gert J.) van|||/items/9e07eeaf-5f02-48b9-bd06-233328c6aa09
Tipo de documento: artigo
Data de publicação:2001
País:España
Recursos:Universidad de Navarra
Repositório:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglês
OAI Identifier:oai:dadun.unav.edu:10171/20190
Acesso em linha:https://hdl.handle.net/10171/20190
Access Level:Acceso aberto
Palavra-chave:Adrenomedullin
Androgen blockade
Neuroendocrine
Prostate cancer
Proadrenomedullin N-terminal 20 peptide
Peptidylglycine a-amidating monooxygenase
Peptidylglycine a-hydroxylating monooxygenase
id ES_c8be6c7ce03e9d90b88faaf91117fcdf
oai_identifier_str oai:dadun.unav.edu:10171/20190
network_acronym_str ES
network_name_str España
repository_id_str
spelling Peptidylglycine alpha-amidating monooxygenase- and proadrenomedullin-derived peptide-associated neuroendocrine differentiation are induced by androgen deprivation in the neoplastic prostateJimenez, N. (Nuria)|||/items/f30692dd-977b-4208-8cdd-35ce1f668019Jongsma, J. (Johan)|||/items/47307705-db15-4c77-98e8-b54451d51cedCalvo-González, A. (Alfonso)|||/items/ac176653-87d5-476b-b2b9-ade455cfa6deKwast, T.H. (Theodorus H. ) van der|||/items/c968ed25-ffcd-432c-b2a1-d31dd5634673Treston, A.M. (Anthony M.)|||/items/2a2177c8-e6d5-486c-841e-62a5423a037bCuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188Schröder, F.H. (Fritz H.)|||/items/f324355b-576d-4b27-817f-0fca445a90aaMontuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596Steenbrugge, G.J. (Gert J.) van|||/items/9e07eeaf-5f02-48b9-bd06-233328c6aa09AdrenomedullinAndrogen blockadeNeuroendocrineProstate cancerProadrenomedullin N-terminal 20 peptidePeptidylglycine a-amidating monooxygenasePeptidylglycine a-hydroxylating monooxygenaseMost PCs show NE differentiation. Several studies have tried to correlate NE expression with disease status, but the reported findings have been contradictory. Prostatic NE cells synthesize peptides with a wide spectrum of potential functions. Some of these active peptides, such as PAMP, are amidated. PAM is the only carboxy-terminal peptide-amidating enzyme identified. We studied expression of PAMP and PAM in normal prostate and prostatic tumors (clinical specimens and human xenograft models) with or without prior androgen-deprivation therapy and found a wide distribution of both molecules in NE subpopulations of all kinds. Although the correlation of either marker to tumor grade, clinical progression or disease prognosis did not reach statistical significance, PAMP- or PAM-immunoreactive cells were induced after androgen-blockade therapy. In the PC-310 and PC-295 androgen-dependent models, PAMP or PAM NE differentiation was induced after castration in different ways, being higher in PC-310, which might explain its long-term survival after androgen deprivation. We show induction of expression of 2 new NE markers in clinical specimens and xenografted PC after endocrine therapy.Wiley BlackwellDadun. Depósito Académico Digital Universidad de Navarra20112011-12-1220012001-01-0120012001-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/20190reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/201902026-06-21T12:47:57Z
dc.title.none.fl_str_mv Peptidylglycine alpha-amidating monooxygenase- and proadrenomedullin-derived peptide-associated neuroendocrine differentiation are induced by androgen deprivation in the neoplastic prostate
title Peptidylglycine alpha-amidating monooxygenase- and proadrenomedullin-derived peptide-associated neuroendocrine differentiation are induced by androgen deprivation in the neoplastic prostate
spellingShingle Peptidylglycine alpha-amidating monooxygenase- and proadrenomedullin-derived peptide-associated neuroendocrine differentiation are induced by androgen deprivation in the neoplastic prostate
Jimenez, N. (Nuria)|||/items/f30692dd-977b-4208-8cdd-35ce1f668019
Adrenomedullin
Androgen blockade
Neuroendocrine
Prostate cancer
Proadrenomedullin N-terminal 20 peptide
Peptidylglycine a-amidating monooxygenase
Peptidylglycine a-hydroxylating monooxygenase
title_short Peptidylglycine alpha-amidating monooxygenase- and proadrenomedullin-derived peptide-associated neuroendocrine differentiation are induced by androgen deprivation in the neoplastic prostate
title_full Peptidylglycine alpha-amidating monooxygenase- and proadrenomedullin-derived peptide-associated neuroendocrine differentiation are induced by androgen deprivation in the neoplastic prostate
title_fullStr Peptidylglycine alpha-amidating monooxygenase- and proadrenomedullin-derived peptide-associated neuroendocrine differentiation are induced by androgen deprivation in the neoplastic prostate
title_full_unstemmed Peptidylglycine alpha-amidating monooxygenase- and proadrenomedullin-derived peptide-associated neuroendocrine differentiation are induced by androgen deprivation in the neoplastic prostate
title_sort Peptidylglycine alpha-amidating monooxygenase- and proadrenomedullin-derived peptide-associated neuroendocrine differentiation are induced by androgen deprivation in the neoplastic prostate
dc.creator.none.fl_str_mv Jimenez, N. (Nuria)|||/items/f30692dd-977b-4208-8cdd-35ce1f668019
Jongsma, J. (Johan)|||/items/47307705-db15-4c77-98e8-b54451d51ced
Calvo-González, A. (Alfonso)|||/items/ac176653-87d5-476b-b2b9-ade455cfa6de
Kwast, T.H. (Theodorus H. ) van der|||/items/c968ed25-ffcd-432c-b2a1-d31dd5634673
Treston, A.M. (Anthony M.)|||/items/2a2177c8-e6d5-486c-841e-62a5423a037b
Cuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188
Schröder, F.H. (Fritz H.)|||/items/f324355b-576d-4b27-817f-0fca445a90aa
Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596
Steenbrugge, G.J. (Gert J.) van|||/items/9e07eeaf-5f02-48b9-bd06-233328c6aa09
author Jimenez, N. (Nuria)|||/items/f30692dd-977b-4208-8cdd-35ce1f668019
author_facet Jimenez, N. (Nuria)|||/items/f30692dd-977b-4208-8cdd-35ce1f668019
Jongsma, J. (Johan)|||/items/47307705-db15-4c77-98e8-b54451d51ced
Calvo-González, A. (Alfonso)|||/items/ac176653-87d5-476b-b2b9-ade455cfa6de
Kwast, T.H. (Theodorus H. ) van der|||/items/c968ed25-ffcd-432c-b2a1-d31dd5634673
Treston, A.M. (Anthony M.)|||/items/2a2177c8-e6d5-486c-841e-62a5423a037b
Cuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188
Schröder, F.H. (Fritz H.)|||/items/f324355b-576d-4b27-817f-0fca445a90aa
Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596
Steenbrugge, G.J. (Gert J.) van|||/items/9e07eeaf-5f02-48b9-bd06-233328c6aa09
author_role author
author2 Jongsma, J. (Johan)|||/items/47307705-db15-4c77-98e8-b54451d51ced
Calvo-González, A. (Alfonso)|||/items/ac176653-87d5-476b-b2b9-ade455cfa6de
Kwast, T.H. (Theodorus H. ) van der|||/items/c968ed25-ffcd-432c-b2a1-d31dd5634673
Treston, A.M. (Anthony M.)|||/items/2a2177c8-e6d5-486c-841e-62a5423a037b
Cuttitta, F. (Frank)|||/items/0f0da08c-0efe-4d3c-97ca-44c38a26e188
Schröder, F.H. (Fritz H.)|||/items/f324355b-576d-4b27-817f-0fca445a90aa
Montuenga-Badia, L.M. (Luis M.)|||/items/4c999705-b2c9-45ac-ba13-3f18594ae596
Steenbrugge, G.J. (Gert J.) van|||/items/9e07eeaf-5f02-48b9-bd06-233328c6aa09
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Dadun. Depósito Académico Digital Universidad de Navarra
dc.subject.none.fl_str_mv Adrenomedullin
Androgen blockade
Neuroendocrine
Prostate cancer
Proadrenomedullin N-terminal 20 peptide
Peptidylglycine a-amidating monooxygenase
Peptidylglycine a-hydroxylating monooxygenase
topic Adrenomedullin
Androgen blockade
Neuroendocrine
Prostate cancer
Proadrenomedullin N-terminal 20 peptide
Peptidylglycine a-amidating monooxygenase
Peptidylglycine a-hydroxylating monooxygenase
description Most PCs show NE differentiation. Several studies have tried to correlate NE expression with disease status, but the reported findings have been contradictory. Prostatic NE cells synthesize peptides with a wide spectrum of potential functions. Some of these active peptides, such as PAMP, are amidated. PAM is the only carboxy-terminal peptide-amidating enzyme identified. We studied expression of PAMP and PAM in normal prostate and prostatic tumors (clinical specimens and human xenograft models) with or without prior androgen-deprivation therapy and found a wide distribution of both molecules in NE subpopulations of all kinds. Although the correlation of either marker to tumor grade, clinical progression or disease prognosis did not reach statistical significance, PAMP- or PAM-immunoreactive cells were induced after androgen-blockade therapy. In the PC-310 and PC-295 androgen-dependent models, PAMP or PAM NE differentiation was induced after castration in different ways, being higher in PC-310, which might explain its long-term survival after androgen deprivation. We show induction of expression of 2 new NE markers in clinical specimens and xenografted PC after endocrine therapy.
publishDate 2001
dc.date.none.fl_str_mv 2001
2001-01-01
2001
2001-01-01
2011
2011-12-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10171/20190
url https://hdl.handle.net/10171/20190
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell
publisher.none.fl_str_mv Wiley Blackwell
dc.source.none.fl_str_mv reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra
instname:Universidad de Navarra
instname_str Universidad de Navarra
reponame_str Dadun. Depósito Académico Digital de la Universidad de Navarra
collection Dadun. Depósito Académico Digital de la Universidad de Navarra
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419311819390976
score 15,300724

Registros relacionados