Serum levels of PCDDs, PCDFs and dl-PCBs in general population residing far and near from an urban waste treatment plant under construction in Gipuzkoa, Basque Country (Spain)

Santa-Marina, Loreto; Irizar, Amaia; Barroeta, Ziortza; Abad, Esteban; Lertxundi, Aitana; Ibarluzea, Jesús; Parera, Jordi; Urbieta, Nerea; Arruti, Elene; Jimeno-Romero, Alba; Zubero, Miren Begoña

Serum levels of PCDDs, PCDFs and dl-PCBs in general population residing far and near from an urban waste treatment plant under construction in Gipuzkoa, Basque Country (Spain)

This research focused on investigating the basal serum concentrations of polychlorinated dibenzo-p-dioxins, dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in the general population residing in two urban-industrial zones near and far from an energy recovery plant under co...

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Autores:	Santa-Marina, Loreto, Irizar, Amaia, Barroeta, Ziortza, Abad, Esteban, Lertxundi, Aitana, Ibarluzea, Jesús, Parera, Jordi, Urbieta, Nerea, Arruti, Elene, Jimeno-Romero, Alba, Zubero, Miren Begoña
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2023
País:	España
Institución:	Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:	DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:	oai:digital.csic.es:10261/333102
Acceso en línea:	http://hdl.handle.net/10261/333102 https://api.elsevier.com/content/abstract/scopus_id/85166220929
Access Level:	acceso abierto
Palabra clave:	Serum Dioxin-like polychlorinated biphenyls Dioxins Energy recovery plant Furans http://metadata.un.org/sdg/7 Ensure access to affordable, reliable, sustainable and modern energy for all

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spelling	Serum levels of PCDDs, PCDFs and dl-PCBs in general population residing far and near from an urban waste treatment plant under construction in Gipuzkoa, Basque Country (Spain)Santa-Marina, LoretoIrizar, AmaiaBarroeta, ZiortzaAbad, EstebanLertxundi, AitanaIbarluzea, JesúsParera, JordiUrbieta, NereaArruti, EleneJimeno-Romero, AlbaZubero, Miren BegoñaSerumDioxin-like polychlorinated biphenylsDioxinsEnergy recovery plantFuranshttp://metadata.un.org/sdg/7Ensure access to affordable, reliable, sustainable and modern energy for allThis research focused on investigating the basal serum concentrations of polychlorinated dibenzo-p-dioxins, dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in the general population residing in two urban-industrial zones near and far from an energy recovery plant under construction in Gipuzkoa, Basque Country (Spain). The study used a cross-sectional design and included 227 participants who were randomly selected from municipal censuses in both areas. The participants were stratified based on age (ranging from 18 to 70 years) and sex. Serum samples were collected from the participants and analysed following the established protocol to measure the concentrations of PCDD/Fs and dl-PCBs. The study used multiple linear regression models to assess the impact of various sociodemographic variables, lifestyle factors, reproductive history, and diet on the variability of the measured compounds in the participants' serum. The median total toxicity equivalent (TEQ) in serum, was 10.58 pg WHO-TEQ2005 g-1 lipid. Serum PCDD levels were lower in the population residing in the "far" zone than the "near" zone. Age was positively associated with both PCDD/F and dl-PCB levels, indicating that older participants had higher concentrations of these compounds in their serum. This finding might be attributed to cumulative exposure over time. In terms of sex differences, women exhibited lower levels of dl-PCBs compared to men. Among lifestyle factors, smokers showed lower levels of dl-PCBs compared to non-smokers. Furthermore, daily alcohol consumption was significantly associated with higher serum levels of these compounds, with daily drinkers showing higher levels than non-drinkers. Consumption of local poultry was associated with significantly higher serum levels and oil consumption with low levels of PCDD/Fs.This research, conducted between 2017 and 2019 before the operation of the Energy Recovery plant, was funded through a public tender (017/11-HH-ZE) by the Gipuzkoa Provincial Council. However, the funding source did not play any part in the study's design, data collection and analysis, or the interpretation and writing of the manuscript.Peer reviewedElsevier0000-0002-5440-52440000-0002-6933-53730000-0003-1024-0190Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/333102https://api.elsevier.com/content/abstract/scopus_id/85166220929reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésEnvironmental researchhttps://doi.org/10.1016/j.envres.2023.116721Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3331022026-05-22T06:33:51Z
dc.title.none.fl_str_mv	Serum levels of PCDDs, PCDFs and dl-PCBs in general population residing far and near from an urban waste treatment plant under construction in Gipuzkoa, Basque Country (Spain)
title	Serum levels of PCDDs, PCDFs and dl-PCBs in general population residing far and near from an urban waste treatment plant under construction in Gipuzkoa, Basque Country (Spain)
spellingShingle	Serum levels of PCDDs, PCDFs and dl-PCBs in general population residing far and near from an urban waste treatment plant under construction in Gipuzkoa, Basque Country (Spain) Santa-Marina, Loreto Serum Dioxin-like polychlorinated biphenyls Dioxins Energy recovery plant Furans http://metadata.un.org/sdg/7 Ensure access to affordable, reliable, sustainable and modern energy for all
title_short	Serum levels of PCDDs, PCDFs and dl-PCBs in general population residing far and near from an urban waste treatment plant under construction in Gipuzkoa, Basque Country (Spain)
title_full	Serum levels of PCDDs, PCDFs and dl-PCBs in general population residing far and near from an urban waste treatment plant under construction in Gipuzkoa, Basque Country (Spain)
title_fullStr	Serum levels of PCDDs, PCDFs and dl-PCBs in general population residing far and near from an urban waste treatment plant under construction in Gipuzkoa, Basque Country (Spain)
title_full_unstemmed	Serum levels of PCDDs, PCDFs and dl-PCBs in general population residing far and near from an urban waste treatment plant under construction in Gipuzkoa, Basque Country (Spain)
title_sort	Serum levels of PCDDs, PCDFs and dl-PCBs in general population residing far and near from an urban waste treatment plant under construction in Gipuzkoa, Basque Country (Spain)
dc.creator.none.fl_str_mv	Santa-Marina, Loreto Irizar, Amaia Barroeta, Ziortza Abad, Esteban Lertxundi, Aitana Ibarluzea, Jesús Parera, Jordi Urbieta, Nerea Arruti, Elene Jimeno-Romero, Alba Zubero, Miren Begoña
author	Santa-Marina, Loreto
author_facet	Santa-Marina, Loreto Irizar, Amaia Barroeta, Ziortza Abad, Esteban Lertxundi, Aitana Ibarluzea, Jesús Parera, Jordi Urbieta, Nerea Arruti, Elene Jimeno-Romero, Alba Zubero, Miren Begoña
author_role	author
author2	Irizar, Amaia Barroeta, Ziortza Abad, Esteban Lertxundi, Aitana Ibarluzea, Jesús Parera, Jordi Urbieta, Nerea Arruti, Elene Jimeno-Romero, Alba Zubero, Miren Begoña
author2_role	author author author author author author author author author author
dc.contributor.none.fl_str_mv	0000-0002-5440-5244 0000-0002-6933-5373 0000-0003-1024-0190 Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv	Serum Dioxin-like polychlorinated biphenyls Dioxins Energy recovery plant Furans http://metadata.un.org/sdg/7 Ensure access to affordable, reliable, sustainable and modern energy for all
topic	Serum Dioxin-like polychlorinated biphenyls Dioxins Energy recovery plant Furans http://metadata.un.org/sdg/7 Ensure access to affordable, reliable, sustainable and modern energy for all
description	This research focused on investigating the basal serum concentrations of polychlorinated dibenzo-p-dioxins, dibenzofurans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (dl-PCBs) in the general population residing in two urban-industrial zones near and far from an energy recovery plant under construction in Gipuzkoa, Basque Country (Spain). The study used a cross-sectional design and included 227 participants who were randomly selected from municipal censuses in both areas. The participants were stratified based on age (ranging from 18 to 70 years) and sex. Serum samples were collected from the participants and analysed following the established protocol to measure the concentrations of PCDD/Fs and dl-PCBs. The study used multiple linear regression models to assess the impact of various sociodemographic variables, lifestyle factors, reproductive history, and diet on the variability of the measured compounds in the participants' serum. The median total toxicity equivalent (TEQ) in serum, was 10.58 pg WHO-TEQ2005 g-1 lipid. Serum PCDD levels were lower in the population residing in the "far" zone than the "near" zone. Age was positively associated with both PCDD/F and dl-PCB levels, indicating that older participants had higher concentrations of these compounds in their serum. This finding might be attributed to cumulative exposure over time. In terms of sex differences, women exhibited lower levels of dl-PCBs compared to men. Among lifestyle factors, smokers showed lower levels of dl-PCBs compared to non-smokers. Furthermore, daily alcohol consumption was significantly associated with higher serum levels of these compounds, with daily drinkers showing higher levels than non-drinkers. Consumption of local poultry was associated with significantly higher serum levels and oil consumption with low levels of PCDD/Fs.
publishDate	2023
dc.date.none.fl_str_mv	2023 2023 2023
dc.type.none.fl_str_mv	info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	http://hdl.handle.net/10261/333102 https://api.elsevier.com/content/abstract/scopus_id/85166220929
url	http://hdl.handle.net/10261/333102 https://api.elsevier.com/content/abstract/scopus_id/85166220929
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Environmental research https://doi.org/10.1016/j.envres.2023.116721 Sí
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str	Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str	DIGITAL.CSIC. Repositorio Institucional del CSIC
collection	DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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Serum levels of PCDDs, PCDFs and dl-PCBs in general population residing far and near from an urban waste treatment plant under construction in Gipuzkoa, Basque Country (Spain)

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