Efectos del extracto de polypodium leucotomos sobre la tumorogénesis inducida por la radiación ultravioleta
Given the photoprotective properties of Polypodium leucotomos extract (EPL), it was proposed that taking it orally would prevent photocarcinogenesis. To test this hypothesis, five studies were undertaken. In the first, ORAC and FRAP methods indicated a notable antioxidant activity for the extract. A...
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| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2010 |
| País: | España |
| Institución: | Universitat Rovira i virgili (URV) |
| Repositorio: | Repositori Institucional de la Universitat Rovira i Virgili |
| OAI Identifier: | oai:urv.cat:TDX:533 |
| Acceso en línea: | https://hdl.handle.net/20.500.11797/TDX533 http://hdl.handle.net/10803/8754 |
| Access Level: | acceso abierto |
| Palabra clave: | 616.5 - Pell. Dermatologia clínica 616 - Patologia. Medicina clínica. Oncologia 615 - Farmacologia. Terapèutica. Toxicologia. Radiologia 6 - Ciències aplicades |
| Sumario: | Given the photoprotective properties of Polypodium leucotomos extract (EPL), it was proposed that taking it orally would prevent photocarcinogenesis. To test this hypothesis, five studies were undertaken. In the first, ORAC and FRAP methods indicated a notable antioxidant activity for the extract. Another three studies weighed the protective effects of the EPL in irradiated test animals, demonstrating its anti-tumor capacity by slowing down the progression of carcinogenesis, thereby lengthening survival. The treatment also: favored the response of the antioxidant system by activating p53 which tended to diminish epidermal cell proliferation; counteracted the signs of light-induced ageing; maintained the number of Langerhans cells; and stimulated the defenses of the tissue. The final study, undertaken in humans, showed that oral administration of encapsulated EPL modifies parameters of the oxidative state of human blood. These results attest to the effectiveness of EPL as a systemic photoprotector when administered orally. |
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