GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma

Moreno Monasterio, Marta; Pedrosa, Leire; Paré Brunet, Laia; Pineda, Estela; Bejarano, Leire; Martínez Soler, Fina; Balasubramaniyan, Veerakumar; Ezhilarasan, Ravesanker; Kallarackal, Naveen; Kim, Sung-Hak; Wang, Jia; Audia, Alessandra; Conroy, Siobhan; Marín Aguilera, Mercedes; Ribalta Farrés, Teresa María; Pujol Farré, Teresa; Herreros, Antonio; Tortosa i Moreno, Avelina; Mira, Helena; Alonso, Marta M.; Gómez-Manzano, Candelaria; Graus Ribas, Francesc; Sulman, Erik P.; Piao, Xianhua; Nakano, Ichiro; Prat Aparicio, Aleix; Bhat, Krishna P.; Iglesia, Núria de la

GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma

A mesenchymal transition occurs both during the natural evolution of glioblastoma (GBM) and in response to therapy. Here, we report that the adhesion G-protein-coupled receptor, GPR56/ADGRG1, inhibits GBM mesenchymal differentiation and radioresistance. GPR56 is enriched in proneural and classical G...

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Autores:	Moreno Monasterio, Marta, Pedrosa, Leire, Paré Brunet, Laia, Pineda, Estela, Bejarano, Leire, Martínez Soler, Fina, Balasubramaniyan, Veerakumar, Ezhilarasan, Ravesanker, Kallarackal, Naveen, Kim, Sung-Hak, Wang, Jia, Audia, Alessandra, Conroy, Siobhan, Marín Aguilera, Mercedes, Ribalta Farrés, Teresa María, Pujol Farré, Teresa, Herreros, Antonio, Tortosa i Moreno, Avelina, Mira, Helena, Alonso, Marta M., Gómez-Manzano, Candelaria, Graus Ribas, Francesc, Sulman, Erik P., Piao, Xianhua, Nakano, Ichiro, Prat Aparicio, Aleix, Bhat, Krishna P., Iglesia, Núria de la
Tipo de recurso:	artículo
Estado:	Versión publicada
Fecha de publicación:	2017
País:	España
Institución:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/118923
Acceso en línea:	https://hdl.handle.net/2445/118923
Access Level:	acceso abierto
Palabra clave:	Glioma Tumors Radioteràpia Gliomas Radiotherapy

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spelling	GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastomaMoreno Monasterio, MartaPedrosa, LeireParé Brunet, LaiaPineda, EstelaBejarano, LeireMartínez Soler, FinaBalasubramaniyan, VeerakumarEzhilarasan, RavesankerKallarackal, NaveenKim, Sung-HakWang, JiaAudia, AlessandraConroy, SiobhanMarín Aguilera, MercedesRibalta Farrés, Teresa MaríaPujol Farré, TeresaHerreros, AntonioTortosa i Moreno, AvelinaMira, HelenaAlonso, Marta M.Gómez-Manzano, CandelariaGraus Ribas, FrancescSulman, Erik P.Piao, XianhuaNakano, IchiroPrat Aparicio, AleixBhat, Krishna P.Iglesia, Núria de laGliomaTumorsRadioteràpiaGliomasTumorsRadiotherapyA mesenchymal transition occurs both during the natural evolution of glioblastoma (GBM) and in response to therapy. Here, we report that the adhesion G-protein-coupled receptor, GPR56/ADGRG1, inhibits GBM mesenchymal differentiation and radioresistance. GPR56 is enriched in proneural and classical GBMs and is lost during their transition toward a mesenchymal subtype. GPR56 loss of function promotes mesenchymal differentiation and radioresistance of glioma initiating cells both in vitro and in vivo. Accordingly, a low GPR56-associated signature is prognostic of a poor outcome in GBM patients even within non-G-CIMP GBMs. Mechanistically, we reveal GPR56 as an inhibitor of the nuclear factor kappa B (NF-κB) signaling pathway, thereby providing the rationale by which this receptor prevents mesenchymal differentiation and radioresistance. A pan-cancer analysis suggests that GPR56 might be an inhibitor of the mesenchymal transition across multiple tumor types beyond GBM.Elsevier2018201820172018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/118923Articles publicats en revistes (Infermeria Fonamental i Clínica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.celrep.2017.10.083Cell Reports, 2017, vol. 21, num. 8, p. 2183-2197https://doi.org/10.1016/j.celrep.2017.10.083cc-by (c) Moreno, Marta et al., 2017http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1189232026-05-29T05:05:01Z
dc.title.none.fl_str_mv	GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma
title	GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma
spellingShingle	GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma Moreno Monasterio, Marta Glioma Tumors Radioteràpia Gliomas Tumors Radiotherapy
title_short	GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma
title_full	GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma
title_fullStr	GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma
title_full_unstemmed	GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma
title_sort	GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma
dc.creator.none.fl_str_mv	Moreno Monasterio, Marta Pedrosa, Leire Paré Brunet, Laia Pineda, Estela Bejarano, Leire Martínez Soler, Fina Balasubramaniyan, Veerakumar Ezhilarasan, Ravesanker Kallarackal, Naveen Kim, Sung-Hak Wang, Jia Audia, Alessandra Conroy, Siobhan Marín Aguilera, Mercedes Ribalta Farrés, Teresa María Pujol Farré, Teresa Herreros, Antonio Tortosa i Moreno, Avelina Mira, Helena Alonso, Marta M. Gómez-Manzano, Candelaria Graus Ribas, Francesc Sulman, Erik P. Piao, Xianhua Nakano, Ichiro Prat Aparicio, Aleix Bhat, Krishna P. Iglesia, Núria de la
author	Moreno Monasterio, Marta
author_facet	Moreno Monasterio, Marta Pedrosa, Leire Paré Brunet, Laia Pineda, Estela Bejarano, Leire Martínez Soler, Fina Balasubramaniyan, Veerakumar Ezhilarasan, Ravesanker Kallarackal, Naveen Kim, Sung-Hak Wang, Jia Audia, Alessandra Conroy, Siobhan Marín Aguilera, Mercedes Ribalta Farrés, Teresa María Pujol Farré, Teresa Herreros, Antonio Tortosa i Moreno, Avelina Mira, Helena Alonso, Marta M. Gómez-Manzano, Candelaria Graus Ribas, Francesc Sulman, Erik P. Piao, Xianhua Nakano, Ichiro Prat Aparicio, Aleix Bhat, Krishna P. Iglesia, Núria de la
author_role	author
author2	Pedrosa, Leire Paré Brunet, Laia Pineda, Estela Bejarano, Leire Martínez Soler, Fina Balasubramaniyan, Veerakumar Ezhilarasan, Ravesanker Kallarackal, Naveen Kim, Sung-Hak Wang, Jia Audia, Alessandra Conroy, Siobhan Marín Aguilera, Mercedes Ribalta Farrés, Teresa María Pujol Farré, Teresa Herreros, Antonio Tortosa i Moreno, Avelina Mira, Helena Alonso, Marta M. Gómez-Manzano, Candelaria Graus Ribas, Francesc Sulman, Erik P. Piao, Xianhua Nakano, Ichiro Prat Aparicio, Aleix Bhat, Krishna P. Iglesia, Núria de la
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Glioma Tumors Radioteràpia Gliomas Tumors Radiotherapy
topic	Glioma Tumors Radioteràpia Gliomas Tumors Radiotherapy
description	A mesenchymal transition occurs both during the natural evolution of glioblastoma (GBM) and in response to therapy. Here, we report that the adhesion G-protein-coupled receptor, GPR56/ADGRG1, inhibits GBM mesenchymal differentiation and radioresistance. GPR56 is enriched in proneural and classical GBMs and is lost during their transition toward a mesenchymal subtype. GPR56 loss of function promotes mesenchymal differentiation and radioresistance of glioma initiating cells both in vitro and in vivo. Accordingly, a low GPR56-associated signature is prognostic of a poor outcome in GBM patients even within non-G-CIMP GBMs. Mechanistically, we reveal GPR56 as an inhibitor of the nuclear factor kappa B (NF-κB) signaling pathway, thereby providing the rationale by which this receptor prevents mesenchymal differentiation and radioresistance. A pan-cancer analysis suggests that GPR56 might be an inhibitor of the mesenchymal transition across multiple tumor types beyond GBM.
publishDate	2017
dc.date.none.fl_str_mv	2017 2018 2018 2018
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/118923
url	https://hdl.handle.net/2445/118923
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Reproducció del document publicat a: https://doi.org/10.1016/j.celrep.2017.10.083 Cell Reports, 2017, vol. 21, num. 8, p. 2183-2197 https://doi.org/10.1016/j.celrep.2017.10.083
dc.rights.none.fl_str_mv	cc-by (c) Moreno, Marta et al., 2017 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc-by (c) Moreno, Marta et al., 2017 http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	15 p. application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	Articles publicats en revistes (Infermeria Fonamental i Clínica) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma

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