Role of Extracellular Vesicles in Chronic Post-Embolic Pulmonary Hypertension: Data from an Experimental Animal Model and Patients
This article belongs to the Special Issue Molecular and Translational Research in Cardiovascular Disease.
| Autores: | , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/400135 |
| Acceso en línea: | http://hdl.handle.net/10261/400135 https://api.elsevier.com/content/abstract/scopus_id/105009160673 |
| Access Level: | acceso abierto |
| Palabra clave: | Chronic thromboembolic pulmonary hypertension Endothelial dysfunction Extracellular vesicles Pulmonary embolism Vascular remodeling |
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Role of Extracellular Vesicles in Chronic Post-Embolic Pulmonary Hypertension: Data from an Experimental Animal Model and Patients |
| title |
Role of Extracellular Vesicles in Chronic Post-Embolic Pulmonary Hypertension: Data from an Experimental Animal Model and Patients |
| spellingShingle |
Role of Extracellular Vesicles in Chronic Post-Embolic Pulmonary Hypertension: Data from an Experimental Animal Model and Patients Mendoza-Zambrano, Elva María Chronic thromboembolic pulmonary hypertension Endothelial dysfunction Extracellular vesicles Pulmonary embolism Vascular remodeling |
| title_short |
Role of Extracellular Vesicles in Chronic Post-Embolic Pulmonary Hypertension: Data from an Experimental Animal Model and Patients |
| title_full |
Role of Extracellular Vesicles in Chronic Post-Embolic Pulmonary Hypertension: Data from an Experimental Animal Model and Patients |
| title_fullStr |
Role of Extracellular Vesicles in Chronic Post-Embolic Pulmonary Hypertension: Data from an Experimental Animal Model and Patients |
| title_full_unstemmed |
Role of Extracellular Vesicles in Chronic Post-Embolic Pulmonary Hypertension: Data from an Experimental Animal Model and Patients |
| title_sort |
Role of Extracellular Vesicles in Chronic Post-Embolic Pulmonary Hypertension: Data from an Experimental Animal Model and Patients |
| dc.creator.none.fl_str_mv |
Mendoza-Zambrano, Elva María Sánchez-López, Verónica Gómez-Rodríguez, Belén García-Lunar, Inés Pereda-Arnau, Daniel Jara Palomares, Luis Elías-Hernández, Teresa García-Álvarez, Ana Otero-Candelera, Remedios |
| author |
Mendoza-Zambrano, Elva María |
| author_facet |
Mendoza-Zambrano, Elva María Sánchez-López, Verónica Gómez-Rodríguez, Belén García-Lunar, Inés Pereda-Arnau, Daniel Jara Palomares, Luis Elías-Hernández, Teresa García-Álvarez, Ana Otero-Candelera, Remedios |
| author_role |
author |
| author2 |
Sánchez-López, Verónica Gómez-Rodríguez, Belén García-Lunar, Inés Pereda-Arnau, Daniel Jara Palomares, Luis Elías-Hernández, Teresa García-Álvarez, Ana Otero-Candelera, Remedios |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Salud Carlos III Sociedad Española de Neumología y Cirugía Torácica Junta de Andalucía Ministerio de Ciencia e Innovación (España) Agencia Estatal de Investigación (España) European Commission Mendoza-Zambrano, Elva María [0000-0002-4516-9059] Pereda-Arnau, Daniel [0000-0002-0526-8722] Jara Palomares, Luis [0000-0002-4125-3376] Elías-Hernández, Teresa [0000-0002-6181-3617] Otero-Candelera, Remedios [0000-0002-2265-1221] Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72] |
| dc.subject.none.fl_str_mv |
Chronic thromboembolic pulmonary hypertension Endothelial dysfunction Extracellular vesicles Pulmonary embolism Vascular remodeling |
| topic |
Chronic thromboembolic pulmonary hypertension Endothelial dysfunction Extracellular vesicles Pulmonary embolism Vascular remodeling |
| description |
This article belongs to the Special Issue Molecular and Translational Research in Cardiovascular Disease. |
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2025 |
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2025 2025 2025 |
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info:eu-repo/semantics/article http://purl.org/coar/resource_type/c_6501 Publisher's version info:eu-repo/semantics/publishedVersion |
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article |
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http://hdl.handle.net/10261/400135 https://api.elsevier.com/content/abstract/scopus_id/105009160673 |
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http://hdl.handle.net/10261/400135 https://api.elsevier.com/content/abstract/scopus_id/105009160673 |
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Inglés |
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Inglés |
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#PLACEHOLDER_PARENT_METADATA_VALUE# info:eu-repo/grantAgreement/AEI//CEX2020-001041-S The underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/biomedicines13061499 https://doi.org/10.3390/biomedicines13061499 Sí |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Multidisciplinary Digital Publishing Institute |
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Multidisciplinary Digital Publishing Institute |
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reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC instname:Consejo Superior de Investigaciones Científicas (CSIC) |
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Consejo Superior de Investigaciones Científicas (CSIC) |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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DIGITAL.CSIC. Repositorio Institucional del CSIC |
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Role of Extracellular Vesicles in Chronic Post-Embolic Pulmonary Hypertension: Data from an Experimental Animal Model and PatientsMendoza-Zambrano, Elva MaríaSánchez-López, VerónicaGómez-Rodríguez, BelénGarcía-Lunar, InésPereda-Arnau, DanielJara Palomares, LuisElías-Hernández, TeresaGarcía-Álvarez, AnaOtero-Candelera, RemediosChronic thromboembolic pulmonary hypertensionEndothelial dysfunctionExtracellular vesiclesPulmonary embolismVascular remodelingThis article belongs to the Special Issue Molecular and Translational Research in Cardiovascular Disease.[Background:] The pathogenesis of chronic thromboembolic pulmonary hypertension (CTEPH) involves a multifaceted interplay of factors, including incomplete thrombus resolution, endothelial dysfunction, and vascular remodeling. Recent studies have highlighted the role of extracellular vesicles (EVs) in vascular diseases, suggesting their potential involvement in CTEPH progression. This study aims to investigate the role of EVs from various cellular sources in the development of CTEPH. Methods[Methods:] An experimental study was conducted using 11 male three-month-old Large-White pigs. The EVs of endothelial origin (EEVs; CD146+), leukocyte-derived EVs (LEVs; CD45+, CD44+), and consistent with mesenchymal-origin EVs (CD90+, CD105+) were quantified. Measurements were taken at baseline, after the first embolization, and prior to each subsequent weekly embolization. Embolizations were repeated until chronic pulmonary hypertension (PH) was generated. Based on these findings, a clinical case-control study was performed involving nine patients previously diagnosed with CTEPH and 18 patients with pulmonary embolism who did not develop CTEPH after two years of follow-up.[Results:] The experimental study, consistent with the mesenchymal-origin EVs, exhibited a progressive decrease below baseline levels; LEVs decreased after PH was established, while EEVs remained elevated throughout the study. Subsequently, in the clinical case-control study, CD45+ LEVs emerged as a significant association of CTEPH, with an odds ratio (OR) of 21.25 (95% CI: 1.91–236.00; p = 0.013).[Conclusions:] Inflammation involving LEVs and EEVs plays a crucial role in sustaining the vascular alterations leading to pulmonary vasculature remodeling in CTEPH.This work was supported by the Carlos III Health Institute [PI11/02308]; Spanish Society of Pulmonology and Thoracic Surgery, SEPAR [124/2011]; Ministry of Economy, Innovation, Science and Employment of the Junta de Andalucía [CVI-6654/2010]; CNIC is supported by the Carlos III Health Institute (ISCIII), the Ministerio de Ciencia e Innovación (MICIU) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIN/AEI/10.13039/501100011033). I.G.-L. is supported by project "PI24/00260", funded by Carlos III Health Institute (ISCIII) and co-funded by the European Union.With funding form the Spanish government through the "Severa Ochoa Centre of Excellence" accreditation (CEX2020-001041-S).Peer reviewedMultidisciplinary Digital Publishing InstituteInstituto de Salud Carlos IIISociedad Española de Neumología y Cirugía TorácicaJunta de AndalucíaMinisterio de Ciencia e Innovación (España)Agencia Estatal de Investigación (España)European CommissionMendoza-Zambrano, Elva María [0000-0002-4516-9059]Pereda-Arnau, Daniel [0000-0002-0526-8722]Jara Palomares, Luis [0000-0002-4125-3376]Elías-Hernández, Teresa [0000-0002-6181-3617]Otero-Candelera, Remedios [0000-0002-2265-1221]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/400135https://api.elsevier.com/content/abstract/scopus_id/105009160673reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI//CEX2020-001041-SThe underlying dataset has been published as supplementary material of the article in the publisher platform at DOI https://doi.org/10.3390/biomedicines13061499https://doi.org/10.3390/biomedicines13061499Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4001352026-05-22T06:33:51Z |
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