The Notch pathway regulates both the proliferation and differentiation of follicular cells in the panoistic ovary of Blattella germanica

The Notch pathway is an essential regulator of cell proliferation and differentiation during development. Its involvement in insect oogenesis has been examined in insect species with meroistic ovaries, and it is known to play a fundamental role in cell fate decisions and the induction of the mitosis...

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Autores: Irles, Paula, Elshaer, Nashwa, Piulachs, Maria-Dolors
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/153345
Acceso en línea:http://hdl.handle.net/10261/153345
Access Level:acceso abierto
Palabra clave:Notch
Panoistic ovary
RNAi
Oogenesis
Cell proliferation
Drosophila
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spelling The Notch pathway regulates both the proliferation and differentiation of follicular cells in the panoistic ovary of Blattella germanicaIrles, PaulaElshaer, NashwaPiulachs, Maria-DolorsNotchPanoistic ovaryRNAiOogenesisCell proliferationDrosophilaThe Notch pathway is an essential regulator of cell proliferation and differentiation during development. Its involvement in insect oogenesis has been examined in insect species with meroistic ovaries, and it is known to play a fundamental role in cell fate decisions and the induction of the mitosis-to-endocycle switch in follicular cells (FCs). This work reports the functions of the main components of the Notch pathway (Notch and its ligands Delta and Serrate) during oogenesis in Blattella germanica, a phylogenetically basal species with panoistic ovary. As is revealed by RNAi-based analyses, Notch and Delta were found to contribute towards maintaining the FCs in an immature, non-apoptotic state. This ancestral function of Notch appears in opposition to the induction of transition from mitosis to endocycle that Notch exerts in Drosophila melanogaster, a change in the Notch function that might be in agreement with the evolution of the insect ovary types. Notch was also shown to play an active role in inducing ovarian follicle elongation via the regulation of the cytoskeleton. In addition, Delta and Notch interactions were seen to determine the differentiation of the posterior population of FCs. Serrate levels were found to be Notch-dependent and are involved in the control of the FC programme, although they would appear to play no crucial role in panoistic ovary oogenesis.This work was supported by the Ministry of Science and Innovation, Spain (grant no. BFU2011-22404), by the Catalan Regional Government (grant no. 2014 SGR 619), and by CONICYT + PAI Concurso Nacional Apoyo al Retorno de Investigadores desde el Extranjero, Convocatoria 2013 + 821320046. P.I. is the recipient of a postdoctoral research grant (BECAS CHILE from CONICYT. N.E. is the recipient of a JAE pre-doctoral research grant from the Consejo Superior de Investigaciones Científicas (CSIC).Peer reviewedRoyal Society (Great Britain)Ministerio de Ciencia e Innovación (España)Generalitat de CatalunyaComisión Nacional de Investigación Científica y Tecnológica (Chile)European CommissionConsejo Superior de Investigaciones Científicas (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201720172016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/153345reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://doi.org/10.1098/rsob.150197Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1533452026-05-22T06:33:51Z
dc.title.none.fl_str_mv The Notch pathway regulates both the proliferation and differentiation of follicular cells in the panoistic ovary of Blattella germanica
title The Notch pathway regulates both the proliferation and differentiation of follicular cells in the panoistic ovary of Blattella germanica
spellingShingle The Notch pathway regulates both the proliferation and differentiation of follicular cells in the panoistic ovary of Blattella germanica
Irles, Paula
Notch
Panoistic ovary
RNAi
Oogenesis
Cell proliferation
Drosophila
title_short The Notch pathway regulates both the proliferation and differentiation of follicular cells in the panoistic ovary of Blattella germanica
title_full The Notch pathway regulates both the proliferation and differentiation of follicular cells in the panoistic ovary of Blattella germanica
title_fullStr The Notch pathway regulates both the proliferation and differentiation of follicular cells in the panoistic ovary of Blattella germanica
title_full_unstemmed The Notch pathway regulates both the proliferation and differentiation of follicular cells in the panoistic ovary of Blattella germanica
title_sort The Notch pathway regulates both the proliferation and differentiation of follicular cells in the panoistic ovary of Blattella germanica
dc.creator.none.fl_str_mv Irles, Paula
Elshaer, Nashwa
Piulachs, Maria-Dolors
author Irles, Paula
author_facet Irles, Paula
Elshaer, Nashwa
Piulachs, Maria-Dolors
author_role author
author2 Elshaer, Nashwa
Piulachs, Maria-Dolors
author2_role author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Generalitat de Catalunya
Comisión Nacional de Investigación Científica y Tecnológica (Chile)
European Commission
Consejo Superior de Investigaciones Científicas (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Notch
Panoistic ovary
RNAi
Oogenesis
Cell proliferation
Drosophila
topic Notch
Panoistic ovary
RNAi
Oogenesis
Cell proliferation
Drosophila
description The Notch pathway is an essential regulator of cell proliferation and differentiation during development. Its involvement in insect oogenesis has been examined in insect species with meroistic ovaries, and it is known to play a fundamental role in cell fate decisions and the induction of the mitosis-to-endocycle switch in follicular cells (FCs). This work reports the functions of the main components of the Notch pathway (Notch and its ligands Delta and Serrate) during oogenesis in Blattella germanica, a phylogenetically basal species with panoistic ovary. As is revealed by RNAi-based analyses, Notch and Delta were found to contribute towards maintaining the FCs in an immature, non-apoptotic state. This ancestral function of Notch appears in opposition to the induction of transition from mitosis to endocycle that Notch exerts in Drosophila melanogaster, a change in the Notch function that might be in agreement with the evolution of the insect ovary types. Notch was also shown to play an active role in inducing ovarian follicle elongation via the regulation of the cytoskeleton. In addition, Delta and Notch interactions were seen to determine the differentiation of the posterior population of FCs. Serrate levels were found to be Notch-dependent and are involved in the control of the FC programme, although they would appear to play no crucial role in panoistic ovary oogenesis.
publishDate 2016
dc.date.none.fl_str_mv 2016
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/153345
url http://hdl.handle.net/10261/153345
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://doi.org/10.1098/rsob.150197
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Royal Society (Great Britain)
publisher.none.fl_str_mv Royal Society (Great Britain)
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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