Study of breast cancer incidence in patients of lymphangioleiomyomatosis.
Molecular evidence has linked the pathophysiology of lymphangioleiomyomatosis (LAM) to that of metastatic breast cancer. Following on this observation, we assessed the association between LAM and subsequent breast cancer. An epidemiological study was carried out using three LAM country cohorts, from...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Instituto de Salud Carlos III (ISCIII) |
| Repositorio: | Repisalud |
| Idioma: | inglés |
| OAI Identifier: | oai:repisalud.isciii.es:20.500.12105/12457 |
| Acceso en línea: | http://hdl.handle.net/20.500.12105/12457 |
| Access Level: | acceso abierto |
| Palabra clave: | Biomarkers, Tumor Breast Neoplasms Female Humans Incidence Japan Lymphangioleiomyomatosis Neoplasm Metastasis Sequence Analysis, DNA Spain United Kingdom |
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Study of breast cancer incidence in patients of lymphangioleiomyomatosis.Nuñez, OlivierRomán, AntonioJohnson, Simon RInoue, YoshikazuHirose, MasakiCasanova, Álvarode Garibay, Gorka RuizHerranz, CarmenBueno-Moreno, GemaBoni, JacopoMateo, FrancescaPetit, AnnaCliment, FinaSoler, TeresaVidal, AugustSánchez-Mut, José VicenteEsteller, ManelLópez, José IgnacioGarcía, NadiaGumà, AnnaOrtega, RaúlPlà, María JesúsCampos, MiriamAnsótegui, EmilioMolina-Molina, MaríaValenzuela, ClaudiaUssetti, PiedadLaporta, RosalíaAncochea, JulioXaubet, AntoniPujana, Miguel AngelPollan-Santamaria, MarinaBiomarkers, TumorBreast NeoplasmsFemaleHumansIncidenceJapanLymphangioleiomyomatosisNeoplasm MetastasisSequence Analysis, DNASpainUnited KingdomMolecular evidence has linked the pathophysiology of lymphangioleiomyomatosis (LAM) to that of metastatic breast cancer. Following on this observation, we assessed the association between LAM and subsequent breast cancer. An epidemiological study was carried out using three LAM country cohorts, from Japan, Spain, and the United Kingdom. The number of incident breast cancer cases observed in these cohorts was compared with the number expected on the basis of the country-specific incidence rates for the period 2000-2014. Immunohistochemical studies and exome sequence analysis were performed in two and one tumors, respectively. All cohorts revealed breast cancer standardized incidence ratios (SIRs) ≥ 2.25. The combined analysis of all cases or restricted to pre-menopausal age groups revealed significantly higher incidence of breast cancer: SIR = 2.81, 95 % confidence interval (CI) = 1.32-5.57, P = 0.009; and SIR = 4.88, 95 % CI = 2.29-9.99, P = 0.0007, respectively. Immunohistochemical analyses showed positivity for known markers of lung metastatic potential. This study suggests the existence of increased breast cancer risk among LAM patients. Prospective studies may be warranted to corroborate this result, which may be particularly relevant for pre-menopausal women with LAM.SpringerAsociación Española Contra el CáncerGovernment of Catalonia (España)Instituto de Salud Carlos IIIMinisterio de Economía y Competitividad (España)Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)20212021-03-2720162016-02-0120162016-02-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/12457reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengES PIE13 00022-ONCOPROFILE,ES FIS PI12 01528ES PI15 00854ES RTICC RD12 0036open accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/124572026-06-12T12:43:37Z |
| dc.title.none.fl_str_mv |
Study of breast cancer incidence in patients of lymphangioleiomyomatosis. |
| title |
Study of breast cancer incidence in patients of lymphangioleiomyomatosis. |
| spellingShingle |
Study of breast cancer incidence in patients of lymphangioleiomyomatosis. Nuñez, Olivier Biomarkers, Tumor Breast Neoplasms Female Humans Incidence Japan Lymphangioleiomyomatosis Neoplasm Metastasis Sequence Analysis, DNA Spain United Kingdom |
| title_short |
Study of breast cancer incidence in patients of lymphangioleiomyomatosis. |
| title_full |
Study of breast cancer incidence in patients of lymphangioleiomyomatosis. |
| title_fullStr |
Study of breast cancer incidence in patients of lymphangioleiomyomatosis. |
| title_full_unstemmed |
Study of breast cancer incidence in patients of lymphangioleiomyomatosis. |
| title_sort |
Study of breast cancer incidence in patients of lymphangioleiomyomatosis. |
| dc.creator.none.fl_str_mv |
Nuñez, Olivier Román, Antonio Johnson, Simon R Inoue, Yoshikazu Hirose, Masaki Casanova, Álvaro de Garibay, Gorka Ruiz Herranz, Carmen Bueno-Moreno, Gema Boni, Jacopo Mateo, Francesca Petit, Anna Climent, Fina Soler, Teresa Vidal, August Sánchez-Mut, José Vicente Esteller, Manel López, José Ignacio García, Nadia Gumà, Anna Ortega, Raúl Plà, María Jesús Campos, Miriam Ansótegui, Emilio Molina-Molina, María Valenzuela, Claudia Ussetti, Piedad Laporta, Rosalía Ancochea, Julio Xaubet, Antoni Pujana, Miguel Angel Pollan-Santamaria, Marina |
| author |
Nuñez, Olivier |
| author_facet |
Nuñez, Olivier Román, Antonio Johnson, Simon R Inoue, Yoshikazu Hirose, Masaki Casanova, Álvaro de Garibay, Gorka Ruiz Herranz, Carmen Bueno-Moreno, Gema Boni, Jacopo Mateo, Francesca Petit, Anna Climent, Fina Soler, Teresa Vidal, August Sánchez-Mut, José Vicente Esteller, Manel López, José Ignacio García, Nadia Gumà, Anna Ortega, Raúl Plà, María Jesús Campos, Miriam Ansótegui, Emilio Molina-Molina, María Valenzuela, Claudia Ussetti, Piedad Laporta, Rosalía Ancochea, Julio Xaubet, Antoni Pujana, Miguel Angel Pollan-Santamaria, Marina |
| author_role |
author |
| author2 |
Román, Antonio Johnson, Simon R Inoue, Yoshikazu Hirose, Masaki Casanova, Álvaro de Garibay, Gorka Ruiz Herranz, Carmen Bueno-Moreno, Gema Boni, Jacopo Mateo, Francesca Petit, Anna Climent, Fina Soler, Teresa Vidal, August Sánchez-Mut, José Vicente Esteller, Manel López, José Ignacio García, Nadia Gumà, Anna Ortega, Raúl Plà, María Jesús Campos, Miriam Ansótegui, Emilio Molina-Molina, María Valenzuela, Claudia Ussetti, Piedad Laporta, Rosalía Ancochea, Julio Xaubet, Antoni Pujana, Miguel Angel Pollan-Santamaria, Marina |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Asociación Española Contra el Cáncer Government of Catalonia (España) Instituto de Salud Carlos III Ministerio de Economía y Competitividad (España) Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) |
| dc.subject.none.fl_str_mv |
Biomarkers, Tumor Breast Neoplasms Female Humans Incidence Japan Lymphangioleiomyomatosis Neoplasm Metastasis Sequence Analysis, DNA Spain United Kingdom |
| topic |
Biomarkers, Tumor Breast Neoplasms Female Humans Incidence Japan Lymphangioleiomyomatosis Neoplasm Metastasis Sequence Analysis, DNA Spain United Kingdom |
| description |
Molecular evidence has linked the pathophysiology of lymphangioleiomyomatosis (LAM) to that of metastatic breast cancer. Following on this observation, we assessed the association between LAM and subsequent breast cancer. An epidemiological study was carried out using three LAM country cohorts, from Japan, Spain, and the United Kingdom. The number of incident breast cancer cases observed in these cohorts was compared with the number expected on the basis of the country-specific incidence rates for the period 2000-2014. Immunohistochemical studies and exome sequence analysis were performed in two and one tumors, respectively. All cohorts revealed breast cancer standardized incidence ratios (SIRs) ≥ 2.25. The combined analysis of all cases or restricted to pre-menopausal age groups revealed significantly higher incidence of breast cancer: SIR = 2.81, 95 % confidence interval (CI) = 1.32-5.57, P = 0.009; and SIR = 4.88, 95 % CI = 2.29-9.99, P = 0.0007, respectively. Immunohistochemical analyses showed positivity for known markers of lung metastatic potential. This study suggests the existence of increased breast cancer risk among LAM patients. Prospective studies may be warranted to corroborate this result, which may be particularly relevant for pre-menopausal women with LAM. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2016-02-01 2016 2016-02-01 2021 2021-03-27 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/20.500.12105/12457 |
| url |
http://hdl.handle.net/20.500.12105/12457 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
ES PIE13 00022-ONCOPROFILE, ES FIS PI12 01528 ES PI15 00854 ES RTICC RD12 0036 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf |
| dc.publisher.none.fl_str_mv |
Springer |
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Springer |
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reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII) |
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Instituto de Salud Carlos III (ISCIII) |
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Repisalud |
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Repisalud |
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