Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain

BACKGROUND: The present report compares prognosis in hospitalized cases with the H1N1 pandemic virus in two seasons. METHODS: Two series of hospitalized patients with laboratory-confirmed H1N1 pandemic influenza have been compared: 813 in the season 2009-2010 and 707 in the season 2010-2011. A detai...

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Autores: Delgado Rodríguez, Miguel, Castilla, Jesús, Godoy i García, Pere, Martín, Vicente, Soldevila, Núria, Alonso Caballero, Jordi, Astray, Jenaro, Baricot, Maretva, Galán, Juan Carlos, Castro, Ady, González Candela, Fernando, Mayoral, José María, Quintana, José María, Pumarola, Tomás, Tamames, Sonia, Sáez, Marc, Domínguez García, Àngela, CIBERESP Cases and Controls in Pandemic Influenza Working Group
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/25309
Acesso em linha:http://hdl.handle.net/10230/25309
http://dx.doi.org/10.1111/irv.12119
Access Level:acceso abierto
Palavra-chave:Grip A (H1N1)
Epidemiologia
Prognosi
Hospitalization
Influenza
Mortality
Prognosis
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spelling Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in SpainDelgado Rodríguez, MiguelCastilla, JesúsGodoy i García, PereMartín, VicenteSoldevila, NúriaAlonso Caballero, JordiAstray, JenaroBaricot, MaretvaGalán, Juan CarlosCastro, AdyGonzález Candela, FernandoMayoral, José MaríaQuintana, José MaríaPumarola, TomásTamames, SoniaSáez, MarcDomínguez García, ÀngelaCIBERESP Cases and Controls in Pandemic Influenza Working GroupGrip A (H1N1)EpidemiologiaPrognosiHospitalizationInfluenzaMortalityPrognosisBACKGROUND: The present report compares prognosis in hospitalized cases with the H1N1 pandemic virus in two seasons. METHODS: Two series of hospitalized patients with laboratory-confirmed H1N1 pandemic influenza have been compared: 813 in the season 2009-2010 and 707 in the season 2010-2011. A detailed history of variables preceding hospital admission and during hospitalization was obtained by interview and clinical charts. A combined endpoint of death admission to intensive care was used as outcome due to the low number of deaths. Logistic regression was applied in the analysis for adverse outcome. RESULTS: Patients of the second season had different characteristics than in the first one (older, more underlying conditions, more malfunctioning organs and more symptoms). Patients with H1N1 pandemic virus when hospitalized were more frequently directly admitted to ICU during the 2010-2011 season than in the previous season (RR=2·10; 95% confidence intervals CI, 1·55-2·85), as a consequence of a higher presence of sepsis and respiratory distress. These patients also showed during hospitalization a higher risk of ICU admission or death (RR=3·22, 95% CI, 2·15-4·83). After adjusting for the differences in risk factors of adverse outcome, patients in the second season showed a higher risk of ICU admission and/or in-hospital death odds ratio (OR=3·77, 95% CI, 2·30-6·18). CONCLUSION: Hospitalized patients with H1N1 pandemic influenza during the second season were more severely affected at hospital admission and showed a worse prognosis than in previous season, independently of the differences found at hospital admission.Wiley201520152013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/25309http://dx.doi.org/10.1111/irv.12119reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésInfluenza and other respiratory viruses. 2013. 7(6): 1336-1342All articles published in this journal are made available under the terms of the Creative Commons License.info:eu-repo/semantics/openAccessoai:recercat.cat:10230/253092026-05-29T05:05:01Z
dc.title.none.fl_str_mv Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
title Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
spellingShingle Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
Delgado Rodríguez, Miguel
Grip A (H1N1)
Epidemiologia
Prognosi
Hospitalization
Influenza
Mortality
Prognosis
title_short Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
title_full Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
title_fullStr Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
title_full_unstemmed Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
title_sort Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
dc.creator.none.fl_str_mv Delgado Rodríguez, Miguel
Castilla, Jesús
Godoy i García, Pere
Martín, Vicente
Soldevila, Núria
Alonso Caballero, Jordi
Astray, Jenaro
Baricot, Maretva
Galán, Juan Carlos
Castro, Ady
González Candela, Fernando
Mayoral, José María
Quintana, José María
Pumarola, Tomás
Tamames, Sonia
Sáez, Marc
Domínguez García, Àngela
CIBERESP Cases and Controls in Pandemic Influenza Working Group
author Delgado Rodríguez, Miguel
author_facet Delgado Rodríguez, Miguel
Castilla, Jesús
Godoy i García, Pere
Martín, Vicente
Soldevila, Núria
Alonso Caballero, Jordi
Astray, Jenaro
Baricot, Maretva
Galán, Juan Carlos
Castro, Ady
González Candela, Fernando
Mayoral, José María
Quintana, José María
Pumarola, Tomás
Tamames, Sonia
Sáez, Marc
Domínguez García, Àngela
CIBERESP Cases and Controls in Pandemic Influenza Working Group
author_role author
author2 Castilla, Jesús
Godoy i García, Pere
Martín, Vicente
Soldevila, Núria
Alonso Caballero, Jordi
Astray, Jenaro
Baricot, Maretva
Galán, Juan Carlos
Castro, Ady
González Candela, Fernando
Mayoral, José María
Quintana, José María
Pumarola, Tomás
Tamames, Sonia
Sáez, Marc
Domínguez García, Àngela
CIBERESP Cases and Controls in Pandemic Influenza Working Group
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Grip A (H1N1)
Epidemiologia
Prognosi
Hospitalization
Influenza
Mortality
Prognosis
topic Grip A (H1N1)
Epidemiologia
Prognosi
Hospitalization
Influenza
Mortality
Prognosis
description BACKGROUND: The present report compares prognosis in hospitalized cases with the H1N1 pandemic virus in two seasons. METHODS: Two series of hospitalized patients with laboratory-confirmed H1N1 pandemic influenza have been compared: 813 in the season 2009-2010 and 707 in the season 2010-2011. A detailed history of variables preceding hospital admission and during hospitalization was obtained by interview and clinical charts. A combined endpoint of death admission to intensive care was used as outcome due to the low number of deaths. Logistic regression was applied in the analysis for adverse outcome. RESULTS: Patients of the second season had different characteristics than in the first one (older, more underlying conditions, more malfunctioning organs and more symptoms). Patients with H1N1 pandemic virus when hospitalized were more frequently directly admitted to ICU during the 2010-2011 season than in the previous season (RR=2·10; 95% confidence intervals CI, 1·55-2·85), as a consequence of a higher presence of sepsis and respiratory distress. These patients also showed during hospitalization a higher risk of ICU admission or death (RR=3·22, 95% CI, 2·15-4·83). After adjusting for the differences in risk factors of adverse outcome, patients in the second season showed a higher risk of ICU admission and/or in-hospital death odds ratio (OR=3·77, 95% CI, 2·30-6·18). CONCLUSION: Hospitalized patients with H1N1 pandemic influenza during the second season were more severely affected at hospital admission and showed a worse prognosis than in previous season, independently of the differences found at hospital admission.
publishDate 2013
dc.date.none.fl_str_mv 2013
2015
2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/25309
http://dx.doi.org/10.1111/irv.12119
url http://hdl.handle.net/10230/25309
http://dx.doi.org/10.1111/irv.12119
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Influenza and other respiratory viruses. 2013. 7(6): 1336-1342
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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