Prediction of effective humoral response to SARS‑CoV‑2 vaccines in healthy subjects by cortical thickness of post‑vaccination reactive lymphadenopathy
Purpose To study the association between ultrasound cortical thickness in reactive post-vaccination lymph nodes and the elicited humoral response and to evaluate the performance of cortical thickness as a predictor of vaccine effectiveness in patients with and without a previous history of COVID-19...
| Autores: | , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Recursos: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/68382 |
| Acesso em linha: | https://hdl.handle.net/10171/68382 |
| Access Level: | acceso abierto |
| Palavra-chave: | COVID-19 vaccines Lymphadenopathy Healthy volunteers Bioquímica clínica |
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Prediction of effective humoral response to SARS‑CoV‑2 vaccines in healthy subjects by cortical thickness of post‑vaccination reactive lymphadenopathyGonzalez-Hernandez, Á. (Álvaro)|||/items/901d58bd-7116-4c53-ae90-206bbc0afbd3Igual-Rouilleault, A.C. (Alba Cristina)|||/items/173d7525-ac8e-468a-9d0b-6a28b3a8f3f3Soriano, I. (Ignacio)|||/items/38b1af95-3525-4dad-8fd2-cfa59ba5ea69Quan, P.L. (Paola Leonor)|||/items/8655ba51-59ec-4749-b78a-f983df154310Reina-González, G. (Gabriel)|||/items/32b42b38-f3b1-4565-a4c2-f2ba3428fc87Pozo-León, J.L. (José Luis) del|||/items/57998d0a-acfc-4fca-81d6-0a140da7b5b8Fernández-Ciriza, L. (Leire)|||/items/04f843e5-e2a5-4495-92a5-a04d0c887b56Fernandez-Montero, A. (Alejandro)|||/items/0d23602b-1c19-44e7-b698-bf919bed4ea7Pina-Insausti, L. (Luis)|||/items/fc0cbd9a-8cf3-4807-87d2-71ba93cb8cfbElizalde-Pérez, A.M. (Arlette María)|||/items/348069ee-103b-4a3d-abb4-84d9c9b439bfCOVID-19 vaccinesLymphadenopathyHealthy volunteersBioquímica clínicaPurpose To study the association between ultrasound cortical thickness in reactive post-vaccination lymph nodes and the elicited humoral response and to evaluate the performance of cortical thickness as a predictor of vaccine effectiveness in patients with and without a previous history of COVID-19 infection. Methods A total of 156 healthy volunteers were recruited and followed prospectively after receiving two COVID-19 vaccination doses using different protocols. Within a week after receiving the second dose, an axillary ultrasound of the ipsilateral vaccinated arm was performed, and serial post-vaccination serologic tests (PVST) were collected. Maximum cortical thickness was chosen as a nodal feature to analyze association with humoral immunity. Total antibodies quantified during consecutive PVST in previously-infected patients and in coronavirus-naïve volunteers were compared (Mann–Whitney U test). The association between hyperplastic-reactive lymph nodes and effective humoral response was studied (odds ratio). The performance of cortical thickness in detecting vaccination effectiveness was evaluated (area under the ROC curve). Results Significantly higher values for total antibodies were observed in volunteers with a previous history of COVID-19 infection (p < 0.001). The odds ratio associating immunized coronavirus-naïve volunteers after 90 and 180 days of the second dose with a cortical thickness ≥ 3 mm was statistically significant (95% CI 1.52–6.97 and 95% CI 1.47–7.29, respectively). The best AUC result was obtained comparing antibody secretion of coronavirus-naïve volunteers at 180 days (0.738). Conclusions Ultrasound cortical thickness of reactive lymph nodes in coronavirus-naïve patients may reflect antibody production and a long-term effective humoral response elicited by vaccination. Clinical relevance statement In coronavirus-naïve patients, ultrasound cortical thickness of post-vaccination reactive lymphadenopathy shows a positive association with protective antibody titers against SARS-CoV-2, especially in the long term, providing new insights into previous publications.Dadun. Depósito Académico Digital Universidad de Navarra20242024-01-1620232023-01-0120232023-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/68382reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/683822026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
Prediction of effective humoral response to SARS‑CoV‑2 vaccines in healthy subjects by cortical thickness of post‑vaccination reactive lymphadenopathy |
| title |
Prediction of effective humoral response to SARS‑CoV‑2 vaccines in healthy subjects by cortical thickness of post‑vaccination reactive lymphadenopathy |
| spellingShingle |
Prediction of effective humoral response to SARS‑CoV‑2 vaccines in healthy subjects by cortical thickness of post‑vaccination reactive lymphadenopathy Gonzalez-Hernandez, Á. (Álvaro)|||/items/901d58bd-7116-4c53-ae90-206bbc0afbd3 COVID-19 vaccines Lymphadenopathy Healthy volunteers Bioquímica clínica |
| title_short |
Prediction of effective humoral response to SARS‑CoV‑2 vaccines in healthy subjects by cortical thickness of post‑vaccination reactive lymphadenopathy |
| title_full |
Prediction of effective humoral response to SARS‑CoV‑2 vaccines in healthy subjects by cortical thickness of post‑vaccination reactive lymphadenopathy |
| title_fullStr |
Prediction of effective humoral response to SARS‑CoV‑2 vaccines in healthy subjects by cortical thickness of post‑vaccination reactive lymphadenopathy |
| title_full_unstemmed |
Prediction of effective humoral response to SARS‑CoV‑2 vaccines in healthy subjects by cortical thickness of post‑vaccination reactive lymphadenopathy |
| title_sort |
Prediction of effective humoral response to SARS‑CoV‑2 vaccines in healthy subjects by cortical thickness of post‑vaccination reactive lymphadenopathy |
| dc.creator.none.fl_str_mv |
Gonzalez-Hernandez, Á. (Álvaro)|||/items/901d58bd-7116-4c53-ae90-206bbc0afbd3 Igual-Rouilleault, A.C. (Alba Cristina)|||/items/173d7525-ac8e-468a-9d0b-6a28b3a8f3f3 Soriano, I. (Ignacio)|||/items/38b1af95-3525-4dad-8fd2-cfa59ba5ea69 Quan, P.L. (Paola Leonor)|||/items/8655ba51-59ec-4749-b78a-f983df154310 Reina-González, G. (Gabriel)|||/items/32b42b38-f3b1-4565-a4c2-f2ba3428fc87 Pozo-León, J.L. (José Luis) del|||/items/57998d0a-acfc-4fca-81d6-0a140da7b5b8 Fernández-Ciriza, L. (Leire)|||/items/04f843e5-e2a5-4495-92a5-a04d0c887b56 Fernandez-Montero, A. (Alejandro)|||/items/0d23602b-1c19-44e7-b698-bf919bed4ea7 Pina-Insausti, L. (Luis)|||/items/fc0cbd9a-8cf3-4807-87d2-71ba93cb8cfb Elizalde-Pérez, A.M. (Arlette María)|||/items/348069ee-103b-4a3d-abb4-84d9c9b439bf |
| author |
Gonzalez-Hernandez, Á. (Álvaro)|||/items/901d58bd-7116-4c53-ae90-206bbc0afbd3 |
| author_facet |
Gonzalez-Hernandez, Á. (Álvaro)|||/items/901d58bd-7116-4c53-ae90-206bbc0afbd3 Igual-Rouilleault, A.C. (Alba Cristina)|||/items/173d7525-ac8e-468a-9d0b-6a28b3a8f3f3 Soriano, I. (Ignacio)|||/items/38b1af95-3525-4dad-8fd2-cfa59ba5ea69 Quan, P.L. (Paola Leonor)|||/items/8655ba51-59ec-4749-b78a-f983df154310 Reina-González, G. (Gabriel)|||/items/32b42b38-f3b1-4565-a4c2-f2ba3428fc87 Pozo-León, J.L. (José Luis) del|||/items/57998d0a-acfc-4fca-81d6-0a140da7b5b8 Fernández-Ciriza, L. (Leire)|||/items/04f843e5-e2a5-4495-92a5-a04d0c887b56 Fernandez-Montero, A. (Alejandro)|||/items/0d23602b-1c19-44e7-b698-bf919bed4ea7 Pina-Insausti, L. (Luis)|||/items/fc0cbd9a-8cf3-4807-87d2-71ba93cb8cfb Elizalde-Pérez, A.M. (Arlette María)|||/items/348069ee-103b-4a3d-abb4-84d9c9b439bf |
| author_role |
author |
| author2 |
Igual-Rouilleault, A.C. (Alba Cristina)|||/items/173d7525-ac8e-468a-9d0b-6a28b3a8f3f3 Soriano, I. (Ignacio)|||/items/38b1af95-3525-4dad-8fd2-cfa59ba5ea69 Quan, P.L. (Paola Leonor)|||/items/8655ba51-59ec-4749-b78a-f983df154310 Reina-González, G. (Gabriel)|||/items/32b42b38-f3b1-4565-a4c2-f2ba3428fc87 Pozo-León, J.L. (José Luis) del|||/items/57998d0a-acfc-4fca-81d6-0a140da7b5b8 Fernández-Ciriza, L. (Leire)|||/items/04f843e5-e2a5-4495-92a5-a04d0c887b56 Fernandez-Montero, A. (Alejandro)|||/items/0d23602b-1c19-44e7-b698-bf919bed4ea7 Pina-Insausti, L. (Luis)|||/items/fc0cbd9a-8cf3-4807-87d2-71ba93cb8cfb Elizalde-Pérez, A.M. (Arlette María)|||/items/348069ee-103b-4a3d-abb4-84d9c9b439bf |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
COVID-19 vaccines Lymphadenopathy Healthy volunteers Bioquímica clínica |
| topic |
COVID-19 vaccines Lymphadenopathy Healthy volunteers Bioquímica clínica |
| description |
Purpose To study the association between ultrasound cortical thickness in reactive post-vaccination lymph nodes and the elicited humoral response and to evaluate the performance of cortical thickness as a predictor of vaccine effectiveness in patients with and without a previous history of COVID-19 infection. Methods A total of 156 healthy volunteers were recruited and followed prospectively after receiving two COVID-19 vaccination doses using different protocols. Within a week after receiving the second dose, an axillary ultrasound of the ipsilateral vaccinated arm was performed, and serial post-vaccination serologic tests (PVST) were collected. Maximum cortical thickness was chosen as a nodal feature to analyze association with humoral immunity. Total antibodies quantified during consecutive PVST in previously-infected patients and in coronavirus-naïve volunteers were compared (Mann–Whitney U test). The association between hyperplastic-reactive lymph nodes and effective humoral response was studied (odds ratio). The performance of cortical thickness in detecting vaccination effectiveness was evaluated (area under the ROC curve). Results Significantly higher values for total antibodies were observed in volunteers with a previous history of COVID-19 infection (p < 0.001). The odds ratio associating immunized coronavirus-naïve volunteers after 90 and 180 days of the second dose with a cortical thickness ≥ 3 mm was statistically significant (95% CI 1.52–6.97 and 95% CI 1.47–7.29, respectively). The best AUC result was obtained comparing antibody secretion of coronavirus-naïve volunteers at 180 days (0.738). Conclusions Ultrasound cortical thickness of reactive lymph nodes in coronavirus-naïve patients may reflect antibody production and a long-term effective humoral response elicited by vaccination. Clinical relevance statement In coronavirus-naïve patients, ultrasound cortical thickness of post-vaccination reactive lymphadenopathy shows a positive association with protective antibody titers against SARS-CoV-2, especially in the long term, providing new insights into previous publications. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023 2023-01-01 2023 2023-01-01 2024 2024-01-16 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/68382 |
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https://hdl.handle.net/10171/68382 |
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Inglés eng |
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Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
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Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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