C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: case report.

Morbidity associated with monoclonal gammopathy of renal significance is high due to the severe renal lesions and the associated systemic alterations. Accordingly, early diagnosis is fundamental, as is stopping the clonal production of immunoglobulins using specific chemotherapy. A 75-year-old man w...

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Detalhes bibliográficos
Autores: Alonso-Titos, Juana, Perea-Ortega, Lara, Sola, Eugenia, Torres-Rueda, Alvaro, León, Myriam, Toledo, Remedios, Duarte, Ana D, Vazquez, Teresa, Martinez-Esteban, Maria Dolores, Bailen, Alicia, Ruiz-Esteban, Pedro, Hernandez, Domingo
Formato: artículo
Fecha de publicación:2018
País:España
Recursos:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17606
Acesso em linha:http://hdl.handle.net/20.500.12105/17606
Access Level:acceso abierto
Palavra-chave:Alternative complement pathway
C3 glomerulonephritis
Case report
Chronic kidney disease
Monoclonal gammopathy
Aged
Complement C3
Glomerulonephritis
Humans
Male
Paraproteinemias
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oai_identifier_str oai:repisalud.isciii.es:20.500.12105/17606
network_acronym_str ES
network_name_str España
repository_id_str
spelling C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: case report.Alonso-Titos, JuanaPerea-Ortega, LaraSola, EugeniaTorres-Rueda, AlvaroLeón, MyriamToledo, RemediosDuarte, Ana DVazquez, TeresaMartinez-Esteban, Maria DoloresBailen, AliciaRuiz-Esteban, PedroHernandez, DomingoAlternative complement pathwayC3 glomerulonephritisCase reportChronic kidney diseaseMonoclonal gammopathyAgedComplement C3GlomerulonephritisHumansMaleParaproteinemiasMorbidity associated with monoclonal gammopathy of renal significance is high due to the severe renal lesions and the associated systemic alterations. Accordingly, early diagnosis is fundamental, as is stopping the clonal production of immunoglobulins using specific chemotherapy. A 75-year-old man with chronic renal disease of unknown origin since 2010 experienced rapid worsening of renal function over a period of 6 mos. Bone marrow biopsy showed monoclonal gammopathy of undetermined significance. Kidney biopsy showed the presence of C3 glomerulonephritis, with exclusive deposits of C3 visible on immunofluorescence and a membranoproliferative pattern on light microscopy. Skin biopsy showed endothelial deposition of complement. Given both the renal and cutaneous involvement the patient was considered to have monoclonal gammopathy of renal significance. We considered an underlying pathogenic mechanism for the renal alteration secondary to activation of the alternative complement pathway by the anomalous immunoglobulin. Despite treatment with plasmapheresis, bortezomib and steroids, advanced chronic kidney disease developed. The possible underlying cause of the monoclonal gammopathy of renal significance suggests that monoclonal gammopathy should be considered in adult patients with membranoproliferative glomerulonephritis.20242024-02-0820182018-06-0820182018-06-08research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/17606reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/176062026-06-12T12:43:37Z
dc.title.none.fl_str_mv C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: case report.
title C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: case report.
spellingShingle C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: case report.
Alonso-Titos, Juana
Alternative complement pathway
C3 glomerulonephritis
Case report
Chronic kidney disease
Monoclonal gammopathy
Aged
Complement C3
Glomerulonephritis
Humans
Male
Paraproteinemias
title_short C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: case report.
title_full C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: case report.
title_fullStr C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: case report.
title_full_unstemmed C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: case report.
title_sort C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: case report.
dc.creator.none.fl_str_mv Alonso-Titos, Juana
Perea-Ortega, Lara
Sola, Eugenia
Torres-Rueda, Alvaro
León, Myriam
Toledo, Remedios
Duarte, Ana D
Vazquez, Teresa
Martinez-Esteban, Maria Dolores
Bailen, Alicia
Ruiz-Esteban, Pedro
Hernandez, Domingo
author Alonso-Titos, Juana
author_facet Alonso-Titos, Juana
Perea-Ortega, Lara
Sola, Eugenia
Torres-Rueda, Alvaro
León, Myriam
Toledo, Remedios
Duarte, Ana D
Vazquez, Teresa
Martinez-Esteban, Maria Dolores
Bailen, Alicia
Ruiz-Esteban, Pedro
Hernandez, Domingo
author_role author
author2 Perea-Ortega, Lara
Sola, Eugenia
Torres-Rueda, Alvaro
León, Myriam
Toledo, Remedios
Duarte, Ana D
Vazquez, Teresa
Martinez-Esteban, Maria Dolores
Bailen, Alicia
Ruiz-Esteban, Pedro
Hernandez, Domingo
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Alternative complement pathway
C3 glomerulonephritis
Case report
Chronic kidney disease
Monoclonal gammopathy
Aged
Complement C3
Glomerulonephritis
Humans
Male
Paraproteinemias
topic Alternative complement pathway
C3 glomerulonephritis
Case report
Chronic kidney disease
Monoclonal gammopathy
Aged
Complement C3
Glomerulonephritis
Humans
Male
Paraproteinemias
description Morbidity associated with monoclonal gammopathy of renal significance is high due to the severe renal lesions and the associated systemic alterations. Accordingly, early diagnosis is fundamental, as is stopping the clonal production of immunoglobulins using specific chemotherapy. A 75-year-old man with chronic renal disease of unknown origin since 2010 experienced rapid worsening of renal function over a period of 6 mos. Bone marrow biopsy showed monoclonal gammopathy of undetermined significance. Kidney biopsy showed the presence of C3 glomerulonephritis, with exclusive deposits of C3 visible on immunofluorescence and a membranoproliferative pattern on light microscopy. Skin biopsy showed endothelial deposition of complement. Given both the renal and cutaneous involvement the patient was considered to have monoclonal gammopathy of renal significance. We considered an underlying pathogenic mechanism for the renal alteration secondary to activation of the alternative complement pathway by the anomalous immunoglobulin. Despite treatment with plasmapheresis, bortezomib and steroids, advanced chronic kidney disease developed. The possible underlying cause of the monoclonal gammopathy of renal significance suggests that monoclonal gammopathy should be considered in adult patients with membranoproliferative glomerulonephritis.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-06-08
2018
2018-06-08
2024
2024-02-08
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/17606
url http://hdl.handle.net/20.500.12105/17606
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419284591017984
score 15.812429

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