The Interplay between cancer biology and the endocannabinoid system - significance for cancer risk, prognosis and response to treatment

The various components of the endocannabinoid system (ECS), such as the cannabinoid receptors (CBRs), cannabinoid ligands, and the signalling network behind it, are implicated in several tumour-related states, both as favourable and unfavourable factors. This review analyses the ECS's complex i...

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Autores: Moreno Guillén, Estefanía, Cavic, Milena, Krivokuca, Ana, Canela Campos, Enric I. (Enric Isidre), 1949-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/172557
Acceso en línea:https://hdl.handle.net/2445/172557
Access Level:acceso abierto
Palabra clave:Receptors cel·lulars
Càncer
Cell receptors
Cancer
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spelling The Interplay between cancer biology and the endocannabinoid system - significance for cancer risk, prognosis and response to treatmentMoreno Guillén, EstefaníaCavic, MilenaKrivokuca, AnaCanela Campos, Enric I. (Enric Isidre), 1949-Receptors cel·lularsCàncerCell receptorsCancerThe various components of the endocannabinoid system (ECS), such as the cannabinoid receptors (CBRs), cannabinoid ligands, and the signalling network behind it, are implicated in several tumour-related states, both as favourable and unfavourable factors. This review analyses the ECS's complex involvement in the susceptibility to cancer, prognosis, and response to treatment, focusing on its relationship with cancer biology in selected solid cancers (breast, gastrointestinal, gynaecological, prostate cancer, thoracic, thyroid, CNS tumours, and melanoma). Changes in the expression and activation of CBRs, as well as their ability to form distinct functional heteromers a ect the cell's tumourigenic potential and their signalling properties, leading to pharmacologically di erent outcomes. Thus, the same ECS component can exert both protective and pathogenic e ects in di erent tumour subtypes, which are often pathologically driven by di erent biological factors. The use of endogenous and exogenous cannabinoids as anti-cancer agents, and the range of e ects they might induce (cell death, regulation of angiogenesis, and invasion or anticancer immunity), depend in great deal on the tumour type and the specific ECS component that they target. Although an attractive target, the use of ECS components in anti-cancer treatment is still interlinked with many legal and ethical issues that need to be considered.MDPI2020202020202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion21 p.application/pdfhttps://hdl.handle.net/2445/172557Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/cancers12113275Cancers, 2020, vol. 12, num. 11, p. 3275https://doi.org/10.3390/cancers12113275cc-by (c) Moreno Guillén, Estefanía et al., 2020http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1725572026-05-29T05:05:01Z
dc.title.none.fl_str_mv The Interplay between cancer biology and the endocannabinoid system - significance for cancer risk, prognosis and response to treatment
title The Interplay between cancer biology and the endocannabinoid system - significance for cancer risk, prognosis and response to treatment
spellingShingle The Interplay between cancer biology and the endocannabinoid system - significance for cancer risk, prognosis and response to treatment
Moreno Guillén, Estefanía
Receptors cel·lulars
Càncer
Cell receptors
Cancer
title_short The Interplay between cancer biology and the endocannabinoid system - significance for cancer risk, prognosis and response to treatment
title_full The Interplay between cancer biology and the endocannabinoid system - significance for cancer risk, prognosis and response to treatment
title_fullStr The Interplay between cancer biology and the endocannabinoid system - significance for cancer risk, prognosis and response to treatment
title_full_unstemmed The Interplay between cancer biology and the endocannabinoid system - significance for cancer risk, prognosis and response to treatment
title_sort The Interplay between cancer biology and the endocannabinoid system - significance for cancer risk, prognosis and response to treatment
dc.creator.none.fl_str_mv Moreno Guillén, Estefanía
Cavic, Milena
Krivokuca, Ana
Canela Campos, Enric I. (Enric Isidre), 1949-
author Moreno Guillén, Estefanía
author_facet Moreno Guillén, Estefanía
Cavic, Milena
Krivokuca, Ana
Canela Campos, Enric I. (Enric Isidre), 1949-
author_role author
author2 Cavic, Milena
Krivokuca, Ana
Canela Campos, Enric I. (Enric Isidre), 1949-
author2_role author
author
author
dc.subject.none.fl_str_mv Receptors cel·lulars
Càncer
Cell receptors
Cancer
topic Receptors cel·lulars
Càncer
Cell receptors
Cancer
description The various components of the endocannabinoid system (ECS), such as the cannabinoid receptors (CBRs), cannabinoid ligands, and the signalling network behind it, are implicated in several tumour-related states, both as favourable and unfavourable factors. This review analyses the ECS's complex involvement in the susceptibility to cancer, prognosis, and response to treatment, focusing on its relationship with cancer biology in selected solid cancers (breast, gastrointestinal, gynaecological, prostate cancer, thoracic, thyroid, CNS tumours, and melanoma). Changes in the expression and activation of CBRs, as well as their ability to form distinct functional heteromers a ect the cell's tumourigenic potential and their signalling properties, leading to pharmacologically di erent outcomes. Thus, the same ECS component can exert both protective and pathogenic e ects in di erent tumour subtypes, which are often pathologically driven by di erent biological factors. The use of endogenous and exogenous cannabinoids as anti-cancer agents, and the range of e ects they might induce (cell death, regulation of angiogenesis, and invasion or anticancer immunity), depend in great deal on the tumour type and the specific ECS component that they target. Although an attractive target, the use of ECS components in anti-cancer treatment is still interlinked with many legal and ethical issues that need to be considered.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/172557
url https://hdl.handle.net/2445/172557
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/cancers12113275
Cancers, 2020, vol. 12, num. 11, p. 3275
https://doi.org/10.3390/cancers12113275
dc.rights.none.fl_str_mv cc-by (c) Moreno Guillén, Estefanía et al., 2020
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Moreno Guillén, Estefanía et al., 2020
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 21 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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