Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients

Background The main objective of the present study was to analyze both clinical characteristics and evolution during hospitalization of a cohort of patients admitted for COVID-19 pneumonia who were not vaccinated, or with a complete or incomplete vaccination schedule. Methods This COVID-19 specializ...

Descripción completa

Detalles Bibliográficos
Autores: Terán Tinedo, José Rafael, González Rubio, Jesús, Nájera López, Alberto, Castany Faro, Andrea, Contreras, María de las Nieves, García, Isabel María, López Mellado, Lourdes, Lorente González, Miguel, Pérez Garvin, Patricia, Sacristán Crespo, Galaxia, Suárez Ortiz, Miguel, Navarro López, Juan de Dios, Jiménez Díaz, Lydia, Landete Rodríguez, Pedro
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad de Castilla-La Mancha
Repositorio:RUIdeRA. Repositorio Institucional de la UCLM
OAI Identifier:oai:ruidera.uclm.es:10578/33689
Acceso en línea:http://dx.doi.org/10.1016/j.eclinm.2022.101453
https://hdl.handle.net/10578/33689
Access Level:acceso abierto
Palabra clave:Ad26.COV2.S
AstraZeneca
Azd1222
BNT162b2
COVID-19
Invasive respiratory care
Janssen
mRNA-1273
Non-invasive respiratory care
Pfizer
Vaccinated patients
Vaccines
id ES_c808d1faffe9bee7d3a578fdad95eb52
oai_identifier_str oai:ruidera.uclm.es:10578/33689
network_acronym_str ES
network_name_str España
repository_id_str
spelling Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patientsTerán Tinedo, José RafaelGonzález Rubio, JesúsNájera López, AlbertoCastany Faro, AndreaContreras, María de las NievesGarcía, Isabel MaríaLópez Mellado, LourdesLorente González, MiguelPérez Garvin, PatriciaSacristán Crespo, GalaxiaSuárez Ortiz, MiguelNavarro López, Juan de DiosJiménez Díaz, LydiaLandete Rodríguez, PedroAd26.COV2.SAstraZenecaAzd1222BNT162b2COVID-19Invasive respiratory careJanssenmRNA-1273Non-invasive respiratory carePfizerVaccinated patientsVaccinesBackground The main objective of the present study was to analyze both clinical characteristics and evolution during hospitalization of a cohort of patients admitted for COVID-19 pneumonia who were not vaccinated, or with a complete or incomplete vaccination schedule. Methods This COVID-19 specialized single-center cohort study of 1888 COVID-19 patients hospitalized at the “Enfermera Isabel Zendal” Emergencies Hospital (HEEIZ), Madrid (Spain) was performed between July 1 and September 30, 2021. It compared the results of 1327 hospitalized unvaccinated patients to 209 hospitalized fully vaccinated and 352 hospitalized partially vaccinated patients. The four different COVID-19 vaccines authorized in Spain during the time-period studied were: BNT162b2 (Pfizer); ChAdOx1 nCoV-19 (AstraZeneca), mRNA-1273 (Moderna); Ad26.COV2.S (Janssen). Findings Hospitalized patients’ median age was 41 years (IQR 33–50) for the unvaccinated and 61 years (IQR 53–67) for the fully vaccinated ones. The main comorbidities were obesity, hypertension and diabetes mellitus. 20% of unvaccinated patients (266) required noninvasive respiratory care, as did 14% (51) of partially and 14% (30) of fully vaccinated; 6% (78) of the unvaccinated patients also needed invasive respiratory care, as did 5% (16) of partially and 11 (5%) fully vaccinated. Interpretation Fully vaccinated patients were 84% (95% CI: 82–86%) less likely to be admitted to hospital, and protection rose for those aged <50 years. Once hospitalized, vaccinated patients displayed more protection against requiring respiratory care than unvaccinated ones, despite being older and having more comorbidities. No differences appeared for the four studied COVID-19 vaccines and complying with vaccination recommendations proved relevant.ELSEVIER202420242022info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://dx.doi.org/10.1016/j.eclinm.2022.101453https://hdl.handle.net/10578/33689reponame:RUIdeRA. Repositorio Institucional de la UCLMinstname:Universidad de Castilla-La ManchaInglés2021-GRIN-31,039info:eu-repo/semantics/openAccessoai:ruidera.uclm.es:10578/336892026-05-27T07:36:41Z
dc.title.none.fl_str_mv Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients
title Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients
spellingShingle Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients
Terán Tinedo, José Rafael
Ad26.COV2.S
AstraZeneca
Azd1222
BNT162b2
COVID-19
Invasive respiratory care
Janssen
mRNA-1273
Non-invasive respiratory care
Pfizer
Vaccinated patients
Vaccines
title_short Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients
title_full Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients
title_fullStr Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients
title_full_unstemmed Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients
title_sort Clinical characteristics and respiratory care in hospitalized vaccinated SARS-CoV-2 patients
dc.creator.none.fl_str_mv Terán Tinedo, José Rafael
González Rubio, Jesús
Nájera López, Alberto
Castany Faro, Andrea
Contreras, María de las Nieves
García, Isabel María
López Mellado, Lourdes
Lorente González, Miguel
Pérez Garvin, Patricia
Sacristán Crespo, Galaxia
Suárez Ortiz, Miguel
Navarro López, Juan de Dios
Jiménez Díaz, Lydia
Landete Rodríguez, Pedro
author Terán Tinedo, José Rafael
author_facet Terán Tinedo, José Rafael
González Rubio, Jesús
Nájera López, Alberto
Castany Faro, Andrea
Contreras, María de las Nieves
García, Isabel María
López Mellado, Lourdes
Lorente González, Miguel
Pérez Garvin, Patricia
Sacristán Crespo, Galaxia
Suárez Ortiz, Miguel
Navarro López, Juan de Dios
Jiménez Díaz, Lydia
Landete Rodríguez, Pedro
author_role author
author2 González Rubio, Jesús
Nájera López, Alberto
Castany Faro, Andrea
Contreras, María de las Nieves
García, Isabel María
López Mellado, Lourdes
Lorente González, Miguel
Pérez Garvin, Patricia
Sacristán Crespo, Galaxia
Suárez Ortiz, Miguel
Navarro López, Juan de Dios
Jiménez Díaz, Lydia
Landete Rodríguez, Pedro
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Ad26.COV2.S
AstraZeneca
Azd1222
BNT162b2
COVID-19
Invasive respiratory care
Janssen
mRNA-1273
Non-invasive respiratory care
Pfizer
Vaccinated patients
Vaccines
topic Ad26.COV2.S
AstraZeneca
Azd1222
BNT162b2
COVID-19
Invasive respiratory care
Janssen
mRNA-1273
Non-invasive respiratory care
Pfizer
Vaccinated patients
Vaccines
description Background The main objective of the present study was to analyze both clinical characteristics and evolution during hospitalization of a cohort of patients admitted for COVID-19 pneumonia who were not vaccinated, or with a complete or incomplete vaccination schedule. Methods This COVID-19 specialized single-center cohort study of 1888 COVID-19 patients hospitalized at the “Enfermera Isabel Zendal” Emergencies Hospital (HEEIZ), Madrid (Spain) was performed between July 1 and September 30, 2021. It compared the results of 1327 hospitalized unvaccinated patients to 209 hospitalized fully vaccinated and 352 hospitalized partially vaccinated patients. The four different COVID-19 vaccines authorized in Spain during the time-period studied were: BNT162b2 (Pfizer); ChAdOx1 nCoV-19 (AstraZeneca), mRNA-1273 (Moderna); Ad26.COV2.S (Janssen). Findings Hospitalized patients’ median age was 41 years (IQR 33–50) for the unvaccinated and 61 years (IQR 53–67) for the fully vaccinated ones. The main comorbidities were obesity, hypertension and diabetes mellitus. 20% of unvaccinated patients (266) required noninvasive respiratory care, as did 14% (51) of partially and 14% (30) of fully vaccinated; 6% (78) of the unvaccinated patients also needed invasive respiratory care, as did 5% (16) of partially and 11 (5%) fully vaccinated. Interpretation Fully vaccinated patients were 84% (95% CI: 82–86%) less likely to be admitted to hospital, and protection rose for those aged <50 years. Once hospitalized, vaccinated patients displayed more protection against requiring respiratory care than unvaccinated ones, despite being older and having more comorbidities. No differences appeared for the four studied COVID-19 vaccines and complying with vaccination recommendations proved relevant.
publishDate 2022
dc.date.none.fl_str_mv 2022
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://dx.doi.org/10.1016/j.eclinm.2022.101453
https://hdl.handle.net/10578/33689
url http://dx.doi.org/10.1016/j.eclinm.2022.101453
https://hdl.handle.net/10578/33689
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv 2021-GRIN-31,039
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv ELSEVIER
publisher.none.fl_str_mv ELSEVIER
dc.source.none.fl_str_mv reponame:RUIdeRA. Repositorio Institucional de la UCLM
instname:Universidad de Castilla-La Mancha
instname_str Universidad de Castilla-La Mancha
reponame_str RUIdeRA. Repositorio Institucional de la UCLM
collection RUIdeRA. Repositorio Institucional de la UCLM
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419229820747776
score 15,301603

Similares en LA Referencia