SyntEyes KTC: higher order statistical eye model for developing keratoconus

[Purpose]: To present and validate a stochastic eye model for developing keratoconus to e.g. improve optical corrective strategies. This could be particularly useful for researchers that do not have access to original keratoconic data.

Detalles Bibliográficos
Autores: Rozema, J. J., Rodríguez, Pablo, Ruiz Hidalgo, Irene, Navarro, Rafael, Tassignon, Marie-José, Koppen, Carina
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/182398
Acceso en línea:http://hdl.handle.net/10261/182398
Access Level:acceso abierto
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repository_id_str
spelling SyntEyes KTC: higher order statistical eye model for developing keratoconusRozema, J. J.Rodríguez, PabloRuiz Hidalgo, IreneNavarro, RafaelTassignon, Marie-JoséKoppen, Carina[Purpose]: To present and validate a stochastic eye model for developing keratoconus to e.g. improve optical corrective strategies. This could be particularly useful for researchers that do not have access to original keratoconic data.[Methods]: The Scheimpflug tomography, ocular biometry and wavefront of 145 keratoconic right eyes were collected. These data were processed using principal component analysis for parameter reduction, followed by a multivariate Gaussian fit that produces a stochastic model for keratoconus (SyntEyes KTC). The output of this model is filtered to remove the occasional incorrect topography patterns by either an automatic or manual procedure. Finally, the output of this keratoconus model is matched to that of the original model for normal eyes using the non‐corneal biometry to obtain a description of keratoconus development.[Results]: The synthetic data generated by the model were found to be significantly equal to the original data (non‐parametric Mann–Whitney equivalence test; 145/154 passed). The variability of the synthetic data, however, was often significantly less than that of the original data, especially for the higher order Zernike terms of corneal elevation (non‐parametric Levene test; p < 0.05/154). These results remained generally the same after applying either filter procedure to remove the synthetic eyes with incorrect topographies. Interpolation between matched pairs of normal and keratoconic SyntEyes appears to provide an adequate model for keratoconus progression.[Conclusion]: The synthetic data provided by the proposed keratoconus model closely resembles actual clinical data and may be used for a range of research applications when (sufficient) real data is not available.This project was supported by research grants by the Flemish government agency for Innovation by Science and Technology (grant nr. IWT/110684) and the Spanish Ministry of Economy and Competitiveness (FIS2014‐58303‐P).Peer reviewedJohn Wiley & SonsFlemish GovernmentFlemish Department of Economy, Science and Innovation (Belgium)Ministerio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/182398reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FIS2014‐58303‐Phttps://doi.org/10.1111/opo.12369Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1823982026-05-22T06:33:51Z
dc.title.none.fl_str_mv SyntEyes KTC: higher order statistical eye model for developing keratoconus
title SyntEyes KTC: higher order statistical eye model for developing keratoconus
spellingShingle SyntEyes KTC: higher order statistical eye model for developing keratoconus
Rozema, J. J.
title_short SyntEyes KTC: higher order statistical eye model for developing keratoconus
title_full SyntEyes KTC: higher order statistical eye model for developing keratoconus
title_fullStr SyntEyes KTC: higher order statistical eye model for developing keratoconus
title_full_unstemmed SyntEyes KTC: higher order statistical eye model for developing keratoconus
title_sort SyntEyes KTC: higher order statistical eye model for developing keratoconus
dc.creator.none.fl_str_mv Rozema, J. J.
Rodríguez, Pablo
Ruiz Hidalgo, Irene
Navarro, Rafael
Tassignon, Marie-José
Koppen, Carina
author Rozema, J. J.
author_facet Rozema, J. J.
Rodríguez, Pablo
Ruiz Hidalgo, Irene
Navarro, Rafael
Tassignon, Marie-José
Koppen, Carina
author_role author
author2 Rodríguez, Pablo
Ruiz Hidalgo, Irene
Navarro, Rafael
Tassignon, Marie-José
Koppen, Carina
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Flemish Government
Flemish Department of Economy, Science and Innovation (Belgium)
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
description [Purpose]: To present and validate a stochastic eye model for developing keratoconus to e.g. improve optical corrective strategies. This could be particularly useful for researchers that do not have access to original keratoconic data.
publishDate 2017
dc.date.none.fl_str_mv 2017
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/182398
url http://hdl.handle.net/10261/182398
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/FIS2014‐58303‐P
https://doi.org/10.1111/opo.12369
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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