Hypergonadotrophinaemia with reduced uterine and ovarian size in women born small-for-gestational-age

BACKGROUND: Fetal growth restraint has been associated with FSH hypersecretion in early infancy and in early post-menarche, and with reduced uterine and ovarian size in adolescence. It is unknown whether these reproductive anomalies persist, respectively, into late infancy and into the reproductive...

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Detalhes bibliográficos
Autores: Ibáñez L, Potau N, Enriquez G, Marcos MV, de Zegher F
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2003
País:España
Recursos:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p6789
Acesso em linha:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6789
Access Level:acceso abierto
Palavra-chave:FSH
LH
ovary
small-for-gestational-age
uterus
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spelling Hypergonadotrophinaemia with reduced uterine and ovarian size in women born small-for-gestational-ageIbáñez LPotau NEnriquez GMarcos MVde Zegher FFSHLHovarysmall-for-gestational-ageuterusBACKGROUND: Fetal growth restraint has been associated with FSH hypersecretion in early infancy and in early post-menarche, and with reduced uterine and ovarian size in adolescence. It is unknown whether these reproductive anomalies persist, respectively, into late infancy and into the reproductive age range. METHODS: We report follow-up findings in two age groups of girls. A cohort of infants [n = 26; n = 10 born appropriate-for-gestational-age (AGA) and n = 16 born small-for-gestational-age (SGA)], who had been studied at the age of similar to4 months, was assessed again at the age of 12 months. A cohort of teenagers (n = 28), who had been studied at the age of similar to14 years, was assessed again at the age of similar to18 years; this group was complemented by a transversal cohort of similar age (n = 19) for a total of 47 young women (n = 27 AGA; n = 20 SGA). In infants, only serum FSH was measured; adolescents underwent endocrine-metabolic screening, ultrasound assessment of uterine-ovarian size, and evaluation of body composition by dual X-ray absorptiometry. RESULTS: Serum FSH levels were higher in SGA than AGA infant girls at 4 and 12 months, and higher in SGA than AGA adolescents at 14 and 18 years (all P < 0.01). Longitudinal ultrasound assessments disclosed a late-adolescent increment of uterine size that was less obvious in SGA than AGA girls. In contrast, ovarian volume remained stable in both subgroups. Compilation of longitudinal and transversal results at 18 years of age corroborated the persistent reduction in the uterine size of SGA girls (by similar to 20%; P < 0.005) and in their ovarian volume (by similar to40%; P < 0.0001); moreover, SGA girls displayed not only a persistent elevation of FSH (by similar to 50%; P < 0.001), but also a rise of LH and fasting insulin, as well as an excess of abdominal fat (all P < 0.01). CONCLUSIONS: The gynaecology of young women born SGA was found to be characterized by hypergonadotrophinaemia and by a reduced uterine and ovarian size.OXFORD UNIV PRESS2003info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6789HUMAN REPRODUCTIONISSN: 02681161ISSNe: 14602350reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p67892026-05-27T12:37:41Z
dc.title.none.fl_str_mv Hypergonadotrophinaemia with reduced uterine and ovarian size in women born small-for-gestational-age
title Hypergonadotrophinaemia with reduced uterine and ovarian size in women born small-for-gestational-age
spellingShingle Hypergonadotrophinaemia with reduced uterine and ovarian size in women born small-for-gestational-age
Ibáñez L
FSH
LH
ovary
small-for-gestational-age
uterus
title_short Hypergonadotrophinaemia with reduced uterine and ovarian size in women born small-for-gestational-age
title_full Hypergonadotrophinaemia with reduced uterine and ovarian size in women born small-for-gestational-age
title_fullStr Hypergonadotrophinaemia with reduced uterine and ovarian size in women born small-for-gestational-age
title_full_unstemmed Hypergonadotrophinaemia with reduced uterine and ovarian size in women born small-for-gestational-age
title_sort Hypergonadotrophinaemia with reduced uterine and ovarian size in women born small-for-gestational-age
dc.creator.none.fl_str_mv Ibáñez L
Potau N
Enriquez G
Marcos MV
de Zegher F
author Ibáñez L
author_facet Ibáñez L
Potau N
Enriquez G
Marcos MV
de Zegher F
author_role author
author2 Potau N
Enriquez G
Marcos MV
de Zegher F
author2_role author
author
author
author
dc.subject.none.fl_str_mv FSH
LH
ovary
small-for-gestational-age
uterus
topic FSH
LH
ovary
small-for-gestational-age
uterus
description BACKGROUND: Fetal growth restraint has been associated with FSH hypersecretion in early infancy and in early post-menarche, and with reduced uterine and ovarian size in adolescence. It is unknown whether these reproductive anomalies persist, respectively, into late infancy and into the reproductive age range. METHODS: We report follow-up findings in two age groups of girls. A cohort of infants [n = 26; n = 10 born appropriate-for-gestational-age (AGA) and n = 16 born small-for-gestational-age (SGA)], who had been studied at the age of similar to4 months, was assessed again at the age of 12 months. A cohort of teenagers (n = 28), who had been studied at the age of similar to14 years, was assessed again at the age of similar to18 years; this group was complemented by a transversal cohort of similar age (n = 19) for a total of 47 young women (n = 27 AGA; n = 20 SGA). In infants, only serum FSH was measured; adolescents underwent endocrine-metabolic screening, ultrasound assessment of uterine-ovarian size, and evaluation of body composition by dual X-ray absorptiometry. RESULTS: Serum FSH levels were higher in SGA than AGA infant girls at 4 and 12 months, and higher in SGA than AGA adolescents at 14 and 18 years (all P < 0.01). Longitudinal ultrasound assessments disclosed a late-adolescent increment of uterine size that was less obvious in SGA than AGA girls. In contrast, ovarian volume remained stable in both subgroups. Compilation of longitudinal and transversal results at 18 years of age corroborated the persistent reduction in the uterine size of SGA girls (by similar to 20%; P < 0.005) and in their ovarian volume (by similar to40%; P < 0.0001); moreover, SGA girls displayed not only a persistent elevation of FSH (by similar to 50%; P < 0.001), but also a rise of LH and fasting insulin, as well as an excess of abdominal fat (all P < 0.01). CONCLUSIONS: The gynaecology of young women born SGA was found to be characterized by hypergonadotrophinaemia and by a reduced uterine and ovarian size.
publishDate 2003
dc.date.none.fl_str_mv 2003
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6789
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=6789
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv OXFORD UNIV PRESS
publisher.none.fl_str_mv OXFORD UNIV PRESS
dc.source.none.fl_str_mv HUMAN REPRODUCTION
ISSN: 02681161
ISSNe: 14602350
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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